A5059165871- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Pediatric health and respiratory diseases
- Blood disorders and treatments
- Pharmacological Effects of Natural Compounds
- Human Health and Disease
- Cancer Immunotherapy and Biomarkers
- Urticaria and Related Conditions
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Oxidative Organic Chemistry Reactions
- Medical and Biological Ozone Research
- Vasculitis and related conditions
- Agricultural Productivity and Crop Improvement
- S100 Proteins and Annexins
- Microbial Metabolites in Food Biotechnology
- Erythrocyte Function and Pathophysiology
- Healthcare Systems and Public Health
- Synthesis and Reactions of Organic Compounds
- Inflammasome and immune disorders
- Chronic Lymphocytic Leukemia Research
- Medical and Biological Sciences
- Bioactive Compounds and Antitumor Agents
- Asymmetric Synthesis and Catalysis
- Dental Anxiety and Anesthesia Techniques
Federal Scientific Center for Vegetable Growing
2025
Gomel State Medical University
2011-2024
St. Petersburg Institute of Bioregulation and Gerontology
2024
Northern State Medical University
2019-2024
Sechenov University
2018-2022
Experimental Station
2019-2022
Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar
2000
State Research Institute for Chemistry and Technology of Organoelement Compounds
1991
Russian Academy of Sciences
1981-1986
A. N. Nesmeyanov Institute of Organoelement Compounds
1980
Relevance. Chicory root ( Cichorium intybus ) is a very valuable technical, vegetable and medicinal crop. The development improvement of scientifically based fertilizer system one the most important issues in agricultural production, since it determines not only level crop yield, but also direction changing, increasing preserving soil fertility general. Material Methods. aim research was to identify effective doses mineral fertilizers methods their application (basic top dressing) ensure...
The propensity for certain individuals to develop staphylococcal recurrent furunculosis (RF) is not fully understood. But among the reasons of its development immune system dysfunctions are described. As in staphylococcus elimination main role played by neutrophils, objective this study was determine nitric oxide (NO) and reactive oxygen species (ROS) production polymo rphonuclear leukocytes (PMNs) patients with RF compare them response normal cells stimulation.The spontaneous...
This study aims to evaluate the clinical efficacy of a hydroxyapatite toothpaste containing Polyol Germanium Complex with threonine in treating dentine hypersensitivity. The also seeks monitor quality life treated hypersensitivity sufferers.This is randomized trial total 120 patients All participants were divided into three groups: assigned GARDA SILK toothpaste; receiving conventional fluoride for comparison purposes, and asked brush their teeth without toothpaste. modified Quigley-Heine...
Background: Research interest in ceruloplasmin (CP) has significantly increased recent years owing to new discoveries of its properties including anti-inflammatory and anti-oxidant effects. Data on CP blood plasma level patients with herpetic infection caused by herpes simplex virus are scarce often contradictory. Most point a reduction the during exacerbation disease gradually return normal values after treatment. There is evidence an increase levels acute period CRHI (chronic recurrent...
While studying the expression of transcription, neoangiogenesis and apoptosis factors in tumour tissue oral fluid 141 patients with mucosa cancer T1-3N0-2M0, it was shown that progression combined postoperative purulent inflammatory complications were associated a high level transcription factors, enhanced translocation hypoxia-inducible factor-1б core, vascular endothelial growth factor activation tissue. The revealed changes underlying disease have reasonably greater severity.
Cytokines play an important role in resistance to herpesvirus infections. Therefore, studies of cytokine profile are necessary recurrent herpetic infection. However, functional network upon remission the disease yielded controversial results. In this paper, we provide some results concerning comprehensive evaluation ex vivo production by whole blood leukocytes drawn from 15 patients observed during clinical Herpes Simplex virus We have found a decrease IL-1β, IL-8 and IL-10 production, as...
Common conditions of daily routine and diet may affect the dental status individuals in organized groups professional communities. The aim this study was to reveal specific aspects orthodox priests monks Yaroslavl region, Russia.Dental assessment 311 participants (111 monks; 111 priests; 90 local residents, not clergymen - as a control group) performed, including Decayed, Missed, Filled Teeth, oral hygiene index (simplified), gingival, Modified Papillary Bleeding Indices (MPBIs). completed...
Emergency medical workers can be at ributed to specialists of extreme prof le activity, as their work is associated with a variety stress factors. 44 paramedics the Arkhangelsk region (mean age 38.1±10.8 years, M±σ) were examined in order identify features occupational activities emergency personnel (NSR). T e following methods we used: scale organizational stress, Mak-Lin, questionnaire «At itude and professional burn-out» Vinokur V.A., test Ch. Spielberger, coping R. Lazarus S. Volkman,...
The article presents the results of assessment role platelets in formation extracellular traps by neutrophils. We have detected ability to oppress neutrophils vitro cultures patients with rheumatoid arthritis (RA) (n = 42) and systemic lupus erythematosus (SLE) 24), but not hemorrhagic vasculitis (GW) 15). study has revealed interrelation NETosis factor RA SLE, as well NET number GW.
Various parameters of neutrophil reactivity, i.e., superoxide anion-forming ability (NВT-test), formation the extracellular networks (NET) and phagocytic function, were studied in sixty-six patients with severe form chronic recurrent herpetic infection. In resting leukocyte cultures from patients, regardless disease stage, NВT scores higher, NET values lower, than control group. stimulated cultures, response was decreased, whereas higher reference values. The changes NET, but not scores,...
The article presents the results of assessment functional features neutrophils in 34 patients with rheumatoid arthritis. study revealed a decrease absorbing and oxygen producing activity associated increased formation neutrophil extracellular traps (NET) dependence parameters NET forming white blood cells on factor, as well spontaneous class disease development.
The cultural in vitro studies evaluated the ability of neutrophils to form extracellular traps response S. aureus induction or caused by its soluble factors healthy individuals. living culture (minimal effective concentration 10 7 CFU/ml) was revealed be most active comparison with other inductors. optimal mode incubation 150 minutes at a temperature 37 °C.
The present-day data on possible pathways of iron influence human immune response and susceptibility to infections have been considered. article describes changes immunologic resistance in conditions low level mechanisms status disturbance as a consequence immunostimulation.
Цель работы – уточнение видового состава возбудителей корневых гнилей цикория, оценка их вредоносности и разработка мер защиты. Полевые исследования проводили на базе РОСЦ-филиала ФГБНУ ФНЦО (Ярославская обл., Ростовский район) лабораторные эксперименты во ВНИИО-филиале (Московская Раменский район). Оценку распространенности цикория с использованием стандартных методов фитопатологических исследований. Анализ пораженных корнеплодов показали, что основными возбудителями были Rhizoctonia...
Мета-анализ был направлен на оценку связи между полиморфизмами rs2107425, rs2839698, rs217727, rs3741219 гена H19 и риском развития рака молочной железы. Поиск публикаций проводили в базах данных Google Scholar PubMed за последние 13 лет. Ассоциацию оценивали по статистическим критериям отношения шансов (ОШ) с 95% доверительным интервалом (ДИ). Для проведения мета-анализа использовали программное обеспечение RevMan (Cochrane Collaboration, 5.3. Копенгаген). оценки четырех полиморфизмов...
The article presents a case of common variable immunodeficiency without clinically significant infectious syndrome with manifestation in the form Crohn’s disease. emphasizes expediency including complex examination chronic inflammatory diseases gastrointestinal tract test for assessing level immunoglobulins main classes serum.
We evaluated some functional indices of neutrophils in 100 adult patients with a verified diagnosis primary antibody production deficiency (44 common variable immunodeficiency – CVID, and 56 selective IgA SigAD). The was made according to the criteria Pan-American Group for Immunodeficiency European Society Immunodeficiency. were based on clinical data, medical history results laboratory tests. All CVID received regular immunoglobulin replacement therapy, SIgAD symptomatic treatment demand....
This study investigates the functional activity of peripheral blood neutrophils in children with hereditary spherocytosis − one most common forms congenital hemolytic anemias. For first time, a comprehensive examination various aspects neutrophil reactivity this pathology was conducted, including their ability to form reactive oxygen species and extracellular traps (NETosis). The results revealed significant changes patients outside crisis, particularly an increased capacity for formation...