A5080616254- Fungal and yeast genetics research
- Photosynthetic Processes and Mechanisms
- Chromosomal and Genetic Variations
- Biofuel production and bioconversion
- Plant Pathogens and Fungal Diseases
- Genetic Mapping and Diversity in Plants and Animals
- CRISPR and Genetic Engineering
- Microbial Metabolic Engineering and Bioproduction
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Plant Molecular Biology Research
- Plant-Microbe Interactions and Immunity
- Protein Hydrolysis and Bioactive Peptides
- Aquaculture Nutrition and Growth
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Collagen: Extraction and Characterization
- RNA modifications and cancer
- Pharmacological Effects of Natural Compounds
- Genomics, phytochemicals, and oxidative stress
- Meat and Animal Product Quality
- Polyamine Metabolism and Applications
- Bacteriophages and microbial interactions
- Plant tissue culture and regeneration
- Plant Reproductive Biology
Nanjing Agricultural University
2015-2025
Wenzhou Medical University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Peking Union Medical College Hospital
2025
Minzu University of China
2025
Hubei University of Chinese Medicine
2021-2024
Hubei Provincial Hospital of Traditional Chinese Medicine
2021-2024
Hubei University
2019-2023
Shantou University
2023
First Affiliated Hospital of Shantou University Medical College
2023
Abstract Estrogen receptor positive (ER+) breast cancer accounts for approximately 70% of cases. Endocrine therapies targeting estrogen are the first line ER+ cancer. However, resistance to these occurs in about half patients, leading decreased survival rates. Inducing ferroptosis is a promising therapeutic strategy treatment refractory and malignant cancers including triple-negative Nevertheless, relatively resistant inducers. Here, we uncovered that ERα suppressed Silencing triggered...
Significance We found that many rapidly evolving plant resistance genes ( R genes) in maize, sorghum, brachypodium, and rice confer to one or more strains of blast disease when present a cultivar genome. These findings suggest fungal pathogen effectors may follow only limited evolutionary pathways increase fitness, an mechanism we call “constrained divergence.” Molecular phylogenetics afford efficient approach -gene identification alternative map-based cloning.
Given the disposability of somatic tissue, selection can favor a higher mutation rate in early segregating soma than germline, as seen some animals. Although plants intra-organismic heterogeneity is poorly resolved, same selectionist logic predict lower shoot root and longer-lived terminal tissues (e.g., leaves) ontogenetically similar short-lived ones petals), that should be deterministic with no significant differences between biological replicates. To address these expectations, we...
Rice blast fungus Magnaporthe oryzae is one of the most devastating pathogens in rice. Avirulence genes this share a gene-for-gene relationship with resistance its host Although numerous studies have shown that rice R-genes are extremely diverse and evolve rapidly their populations, little known about evolutionary patterns Avr-genes pathogens. Here, six well-characterized seven randomly selected non-Avr control were used to investigate genetic variations 62 strains from different parts...
Zymomonas mobilis is a model bacterial ethanologen with many systems biology studies reported. Besides lignocellulosic ethanol production, Z. has been developed as platform for biochemical production through metabolic engineering. However, identification and rigorous understanding of the genetic origins cellular function, especially those based in non-coding region DNA, such promoters ribosomal binding sites (RBSs), are still its infancy. This knowledge crucial effective application to new...
Social hymenoptera, the honey bee (Apis mellifera) in particular, have ultra-high crossover rates and a large degree of intra-genomic variation rates. Aligned with haploid genomics males, this makes them potential model for examining causes consequences crossing over. To address why social insects such high crossing-over this, we constructed high-resolution recombination atlas by sequencing 55 individuals from three colonies an average marker density 314 bp/marker.We find over to be...
Summary Numerous studies have argued that environmental variations may contribute to evolution through the generation of novel heritable via meiotic recombination, which plays a crucial role in crop domestication and improvement. Rice is one most important staple crops, but no direct estimate recombination events has yet been made at fine scale. Here, we address this limitation by sequencing 41 rice individuals with high coverage c . 900 000 accurate markers. An average 33.9 crossover ( 4.53...
In the present study, response surface methodology was performed to investigate effects of extraction parameters on pepsin-solubilised collagen (PSC) from skin giant croaker Nibea japonica. The optimum conditions PSC were as follows: concentration pepsin 1389 U/g, solid-liquid ratio 1:57 and hydrolysis time 8.67 h. Under these conditions, yield up 84.85%, which is well agreement with predict value 85.03%. japonica then characterized type I by using sodium dodecyl sulfate polyacrylamide gel...
Significance Finding the genes that control a complex trait is difficult because each gene may have only minor phenotypic effects. Quantitative loci mapping and genome-wide association study techniques been developed for this purpose but are laborious time-consuming. Here we method combining pedigree analysis, whole-genome sequencing, CRISPR-Cas9 technology. By sequencing parents descendants of IR8, Green Revolution “miracle rice,” identified many had retained in by selection high yield....
Aims: Ferroptosis plays important roles in tumorigenesis and cancer therapy. Zoledronic acid is known to inhibit the activity of farnesyl pyrophosphate synthase, a key enzyme mevalonate pathway. We examined whether zoledronic can growth osteosarcoma cells by inducing ferroptosis. Methods: Cell viability was analyzed using CCK8 reagent counting with trypan blue exclusion. markers including lipid peroxide PTGS2 expression were flow cytometry, western blot, quantitative PCR analyses. Cellular...
Summary Plant resistance genes ( R genes) harbor tremendous allelic diversity, constituting a robust immune system effective against microbial pathogens. Nevertheless, few functional have been identified for even the best‐studied pathosystems. Does this limited repertoire reflect specificity, with most having defeated by former pests, or do plants rich diversity of genes, composite behavior which is yet to be characterized? Here, we survey 332 NBS ‐ LRR cloned from five resistant Oryza...
Effective triage of high-risk human papillomavirus (hrHPV)+ women is warranted to avoid unnecessary referral and overtreatment. Molecular tests have recently begun impact cervical intraepithelial neoplasia grade 3 (CIN3) or cancer (CC), termed CIN3+, detection. We find that zinc finger protein 671 methylation (ZNF671m) test has superior performance for CIN3+ detection in all single molecular tests, including HPV16/18 genotyping, paired box gene 1 (PAX1m), ZNF671m, the training set. Using...
Protein kinases are essential cellular signal modulators involved in tumorigenesis, metastasis, immune response, and drug resistance. However, the comprehensive features clinical significance of protein gastric cancer (GC) remain inconclusive. We analyzed transcriptional profiles GC patients from GEO TCGA databases. Based on differentially expressed kinase genes (DE-KGs), a novel cluster was identified to assess its association with patient survival tumor microenvironment (TME) GC....
Abstract Background Repeat-induced point (RIP) mutation in Neurospora crassa degrades transposable elements by targeting repeats with C→T mutations. Whether RIP affects core genomic sequence important ways is unknown. Results By parent-offspring whole genome sequencing, we estimate a rate (3.38 × 10 −6 per bp generation) that two orders of magnitude higher than reported for any non-viral organism, 93–98% mutations being RIP-associated. are, however, relatively rare coding sequence, part...
Abstract To maintain genome integrity, repeat sequences are subject to heterochromatin inactivation and, in Neurospora, repeat-induced point mutation (RIP). The initiating factors behind both poorly understood. We resolve the paradoxical observation that newly introduced Repeat-Linker-Repeat (R-L-R) constructs require RID alone for RIP, while genomic repeats RIPed absence of RID, showing eu- and hetero- chromatic handled differently, latter additionally requiring DIM-2. differences between...
The ERECTA family genes (ERfs) have been found to play diverse functions in Arabidopsis, including controlling cell proliferation and growth, regulating stomata patterning, responding various stresses. This wide range of has rendered them as a potential candidate for crop improvement. However, information on their functional roles, particularly morphological impact, genomes, such rice, is limited. Here, through evolutionary prediction, we first depict the trajectory ER family, show that...
Gibberellin (GA) functions as an essential natural regulator of growth and development in plants. For each step the GA metabolic pathway, different copy numbers can be found species, is case with 13 genes across four enzymatic steps rice (
The one-step blending approach has been suggested for genomic prediction in dairy cattle. core of this is to incorporate pedigree and phenotypic information non-genotyped animals. objective study was investigate the improvement accuracy using method Chinese Holstein Three methods, GBLUP (genomic best linear unbiased prediction), original with a relationship matrix, adjusted an were compared respect five milk production traits Holstein. For two de-regressed proofs 17 509 cows, including 424...