A5067414676- Thyroid Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- S100 Proteins and Annexins
Seoul National University
2016-2019
Follicular thyroid carcinoma (FTC) and benign follicular adenoma (FA) are indistinguishable by preoperative diagnosis due to their similar histological features. Here we report the first RNA sequencing study of these tumors, with data for 30 minimally invasive FTCs (miFTCs) 25 FAs. We also compared 77 classical papillary carcinomas (cPTCs) 48 variant PTCs (FVPTCs) observe differences in molecular properties. Mutations H/K/NRAS, DICER1, EIF1AX, IDH1, PTEN, SOS1, SPOP were identified miFTC or...
The BRAFV600E mutation acts as an initiator of cancer development in papillary thyroid carcinoma (PTC). Gene expression changes caused by the may have important role development.To study genomic alterations mutation, we made human cell lines that harbor wild-type BRAF gene (Nthy/WT) and V600E mutant-type (Nthy/V600E).Flow cytometry western blotting showed stable transfection gene. In functional experiments, Nthy/V600E increased anchorage-independent growth invasion through Matrigel, compared...
Preoperative diagnosis of thyroid nodules reduces unnecessary surgery. Circulating tumor cells (CTCs) may contain information primary tumor(s). We asked whether the peripheral blood expression genes specific for circulating differentiates benign from malignant nodules. Peripheral mononuclear nodule patients (n = 20) were isolated preoperatively and seven CTC-associated was measured in with nodule(s) 20). Among tested genes, SLC5A5 LGALS3 validated a larger number 64) our results show that...