A5102706326- Salivary Gland Disorders and Functions
- Marine Biology and Environmental Chemistry
- Diabetes Management and Research
- Folate and B Vitamins Research
- Cassava research and cyanide
- Diabetes and associated disorders
- Proteoglycans and glycosaminoglycans research
- Birth, Development, and Health
- Collagen: Extraction and Characterization
- Circadian rhythm and melatonin
- Polyamine Metabolism and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Pancreatic function and diabetes
- Porphyrin Metabolism and Disorders
- Bone Tissue Engineering Materials
- Sphingolipid Metabolism and Signaling
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Diabetes Treatment and Management
- Diabetes Management and Education
- Organometallic Compounds Synthesis and Characterization
- T-cell and Retrovirus Studies
Tokyo University of Science
2016-2020
Tottori University
2020
National Center for Geriatrics and Gerontology
2018-2019
Juntendo University
2015
Nagoya University
2014
Significance Our studies demonstrate that the regulation of endothelial cellular senescence emerges as an additional mechanism underlying antiatherogenic properties liver X receptor (LXR) agents. Furthermore, our data suggest combination therapy with LXR agents and metformin may provide a clinically useful therapeutic strategy to alleviate activation-mediated adverse effect on triglyceride metabolism. The beneficial effects activation appear be reduced reactive oxygen species levels...
Mouse mast cell proteases (mMCP)-1 and -2 are specifically expressed in mucosal cells (MCs). However, the transcriptional regulation mechanism of Mcpt1 Mcpt2 genes induced MCs is largely unknown. In current study, we found that TGF-β stimulation drastically upregulation mRNA mouse bone marrow-derived (BMMCs). TGF-β-induced expression was markedly suppressed by transfection with small interfering RNA targeting Smad2 or Smad4 moderately reduced Smad3 RNA. We next examined roles hematopoietic...
Food additives, such as hypochlorous acid water, sodium metabisulfite, and sulfite, strongly affect the chemical biological properties of vitamin B12 (cyanocobalamin) in aqueous solution. When cyanocobalamin (10 μmol/L) was treated with these compounds, water (an effective chlorine concentration 30 ppm) rapidly reacted cyanocobalamin. The maximum absorptions at 361 550 nm completely disappeared by 1 h, activity lost. There were no significant changes observed absorption spectra for 0.01%...
Bmi-1 prevents stem cell aging, at least partly, by blocking expression of the cyclin-dependent kinase inhibitor p16Ink4a. Therefore, dysregulation Bmi-1/p16Ink4a pathway is considered key to loss tissue homeostasis and development associated degenerative diseases during aging. However, because knockout (KO) mice die within 20 weeks after birth, it difficult determine exactly where when occurs aging in vivo. Using real-time vivo imaging p16Ink4a Bmi-1-KO mice, we uncovered a novel function...
The aim of this study was to investigate the efficacy insulin degludec used for basal-bolus regimen after switching from twice-daily basal in Japanese patients with type 1 diabetes mellitus. subjects were 22 treated insulin. Basal switched once-daily injection 10% dose reduction. HbA1c and fasting plasma glucose (FPG) measured before 12 weeks switching. frequency hypoglycemic episodes, standard deviation (SD) blood glucose, mean daily difference (MODD) evaluated by continuous monitoring...
Abstract Aim Our recent case report of organotin intoxication showed higher ratio urinary trimethyl tin (TMT) to dimethyl (DMT) than those the previous cases exposed only DMT, suggesting co-exposure DMT and TMT occurred. The present study investigated how reflect blood respectively, evaluate them as biomarkers for TMT/DMT exposure. Methods from collected at different time points three patients intoxicated with organotins were measured HPLC-ICP/MS. Previously published data used comparison....
Nocturnal hypoglycemia is a serious problem in the management of diabetes mellitus (DM). The average daily risk range (ADRR) was value created to access blood glucose variability. ADRR can be calculated using self-monitoring (SMBG) values and reported sensitive both hyperglycemia hypoglycemia. However, usefulness Asian type 1 patients with DM (T1DM) detect nocturnal has not been elucidated yet. In this study, we recruited 28 Japanese T1DM. All wore outpatient continuous monitoring (CGM) for...