A5088367170- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Silymarin and Mushroom Poisoning
- Synthesis and bioactivity of alkaloids
- Synthesis and biological activity
- Cancer-related Molecular Pathways
- Multimodal Machine Learning Applications
- Pharmacological Effects and Toxicity Studies
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Cholesterol and Lipid Metabolism
- Image Processing Techniques and Applications
- Inflammatory mediators and NSAID effects
- CCD and CMOS Imaging Sensors
- Enzyme function and inhibition
- Ubiquitin and proteasome pathways
- Synthesis and Characterization of Heterocyclic Compounds
- IoT-based Smart Home Systems
- Nanoparticle-Based Drug Delivery
- Cell death mechanisms and regulation
- Neonatal Health and Biochemistry
- Machine Learning in Healthcare
- Neural Networks and Applications
- Fibroblast Growth Factor Research
Stanford University
2022-2025
Mohamed bin Zayed University of Artificial Intelligence
2024
University of Babylon
2023
University of Toledo
2017-2022
Mustansiriyah University
2022
Middle Technical University
2020
Al-Balqa Applied University
2016
Center for Rheumatology
2015
The COVID-19 pandemic caused a global health crisis that resulted in millions of deaths. Effective vaccines have played central roles curtailing the pandemic. Here, we developed down-converting near-infrared IIb (NIR-IIb; 1500 to 1700 nanometers) luminescent, pure NaErF4@NaYF4 rare-earth nanoparticle (pEr) as vaccine carriers. pEr nanoparticles were coated with three layers cross-linked biocompatible polymers (pEr-P3; ~55 and conjugated receptor binding domain (RBD) severe acute respiratory...
This study was designed to determine the in vitro mechanisms by which novel silybin derivative, (E)-3-(3-(benzyloxy) phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (HM015k or 15k), produces its anticancer efficacy ovarian cancer cells. Compound 15k induced apoptosis cells a time-dependent manner significantly upregulating expression of Bax and Bak downregulating Bcl2. Interestingly, cleavage p21 into more efficacious cleaved form, p18. In addition, caspase 3 9 were their active forms, inducing...
Telemedicine has increased the number of ways in which healthcare can be delivered across places and countries instead requiring provider recipient to present same place. One application telemedicine is exchange medical images between remotely located entities. However, a major obstacle faces providing confidentiality, integrity, authenticity transmitted images. In this paper, we propose hybrid algorithm combines encryption digital watermarking techniques order provide required integrity...
Thienopyrimidines containing a thiophene ring fused to pyrimidine are reported have wide-spectrum of anticancer efficacy in vitro. Here, we report for the first time that thieno[3,2-d]pyrimidine-based compounds, also known as RP series, prostate cancer cells. The compound RP-010 was efficacious against both PC-3 and DU145 (PC) cells (IC50 < 1 µM). cytotoxicity significantly lower non-PC, CHO, CRL-1459 cell lines. (0.5, 1, 2, 4 µM) arrested G2 phase cycle, induced mitotic catastrophe...
Internet of Things (IoT) is a rapidly developing technology that enables “devices” to communicate and share information amongst them without human control. The devices have the features internet connectivity networking. Due increasing demands secure environment in IoT application, security has become crucial aspect on which researchers been increasingly focused. Connecting can facilitate intruders attack as they access data from anywhere globe. In this work, an encryption–decryption...
The promising zero-shot generalization of vision-language models such as CLIP has led to their adoption using prompt learning for numerous downstream tasks. Previous works have shown test-time tuning entropy minimization adapt text prompts unseen domains. While effective, this overlooks the key cause performance degradation domains -- distribution shift. In work, we explicitly handle problem by aligning out-of-distribution (OOD) test sample statistics those source data tuning. We use a...
The inhibition of apoptosis, disruption cellular microtubule dynamics, and over-activation the epithelial mesenchymal transition (EMT), are involved in progression, metastasis, resistance colorectal cancer (CRC). Therefore, design a molecule that can target these pathways together is very effective strategy to reverse CRC progression metastasis. In this study, twelve novel silybin derivatives, HM015a-HM015k (15a-15k) compound 17, were screened for their cytotoxicity cell lines. Compounds...
One-pot, two-step, total synthesis of naturally occurring xenortides A, B, C and D (Xens A–D).
New chrysin-De-allyl-Pac-1 hybrid analogues, tethered with variable heterocyclic systems (4a–4o), were rationally designed and synthesized. The target compounds screened for in vitro antiproliferative efficacy the triple-negative breast cancer (TNBC) cell line, MDA-MB-231, normal human mammary epithelial cells (HMECs). Two compounds, 4g 4i, had highest selectivity towards MDA-MB-231 cells, thus, further evaluated by mechanistic experiments. results indicated that both 4i induced apoptosis...
Multidrug resistance (MDR) is a continuing clinical problem that limits the efficacy of chemotherapy in cancer. The over expression ATP-binding cassette (ABC) family G2 (ABCG2) transporter one main mechanisms mediates MDR Molecular modeling data indicated cariprazine, dopamine D2/D3 receptor partial agonist, had significant binding affinity for ABCG2 with Glide XP score −6.515. Therefore, this vitro study, we determined effect cariprazine on resulting from overexpression transporters. Alone,...
In this study, we designed, synthesized and evaluated, in vitro, novel chalcone analogs containing dialkylamino pharmacophores the cervical cancer cell line, OV2008. The compound,
In this paper, laboratory tests were used to determine the effects of skewness and pilecap elevation on local scour complex bridge piers.The 1:50 scale river models represent Beta piers in Babylon Province Ali Al-Gharbi Missan Province.The model pier consists circular columns, rectangular pile-cap, 2×4 array piles below for Bridge 2×3 Bridge.Four different skew-angles (=0°, 30°, 45°, 60°) pile-cap elevations corresponding bed level are used.All experiments conducted twenty-four hours.Results...
In this study, we aimed to obtain a comprehensive account of the human cytosolic sulfotransferases (SULTs) that are capable sulfating 6-O-desmethylnaproxen (O-DMN), major metabolite naproxen. Of 13 known SULTs tested, 7 (SULT1A1, SULT1A2, SULT1A3, SULT1B1, SULT1C2, SULT1C4, and SULT1E1) displayed O-DMN-sulfating activity, when analyzed using an elevated substrate concentration (500 μmol·L-1) together with 14 μmol·L-1 sulfate donor, 3'-phosphoadenosine-5'-phosphosulfate (PAPS). At 10 O-DMN...
The congestion of road traffic is one the most problems facing ambulance transportation to provide fast healthcare service for patient. In this work, tracking with messages transfer system has been designed and implemented such that a central monitoring unit can observe using MQTT IoT protocol. Where each vehicle occupied an intelligent embedded (Raspberry Pi) unit. When being in road, it will communicate other or by means CoAP protocol as direct device communication. proposed driver use...
Since their inception, Vision Transformers (ViTs) have emerged as a compelling alternative to Convolutional Neural Networks (CNNs) across wide spectrum of tasks. ViTs exhibit notable characteristics, including global attention, resilience against occlusions, and adaptability distribution shifts. One underexplored aspect is potential for multi-attribute learning, referring ability simultaneously grasp multiple attribute-related In this paper, we delve into the learning capability ViTs,...
Medical vision-language models (Med-VLMs) trained on large datasets of medical image-text pairs and later fine-tuned for specific tasks have emerged as a mainstream paradigm in image analysis. However, recent studies highlighted the susceptibility these Med-VLMs to adversarial attacks, raising concerns about their safety robustness. Randomized smoothing is well-known technique turning any classifier into model that certifiably robust perturbations. this approach requires retraining...