A5052371189- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Hematopoietic Stem Cell Transplantation
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Blood disorders and treatments
- Nutrition and Health in Aging
- Frailty in Older Adults
- Palliative Care and End-of-Life Issues
The University of Texas Health Science Center at San Antonio
2024
Methodist Healthcare
2020-2021
The University of Texas at Austin
2021
Houston Methodist
2019
Methodist Hospital
2019
Austin College
2015
Texas College
2015
CHRISTUS Transplant Institute
2015
Introduction Cisplatin has ubiquitous use throughout many cancer types and is incorporated in various regimens. Nephrotoxicity a well-known side effect of cisplatin, occurring up to one third patients. Early clinical data showed elevated peak concentrations are correlated with increased incidence nephrotoxicity, suggesting prolonging infusion duration may abate this known toxicity. A recent study there was no difference rates acute kidney injury (AKI) between rapid (1-h) standard (3-h)...
There are limited data available supporting the use of recombinant granulocyte colony–stimulating factor (G-CSF), tbo-filgrastim, rather than traditionally used filgrastim to mobilize peripheral blood stem cells (PBSC) or accelerate engraftment after autologous cell transplantation (ASCT). We sought compare efficacy and cost tbo-filgrastim in these settings. Patients diagnosed with lymphoma plasma disorders undergoing G-CSF mobilization, without plerixafor, were included this retrospective...
Autologous hematopoietic stem cell transplantation (HSCT) recipients are at increased risk of developing life-threatening infections. There is discordance in published recommendations for timing pre- and post-transplant antimicrobial prophylaxis this patient population, these unsubstantiated by any comparative analyses.
The need to train oncologists address the complexities of aging population has been a focus educational initiatives and strategies since 1980s. However, large gaps in dissemination implementation geriatric oncology curricula are still present. Currently, few resources exist for training programs implement formal curriculum. We aimed create formalized introductory course teach geriatrics trainees principles oncology. Curriculum presentations were delivered both hematology/oncology fellows...
While various peripheral blood stem cell (PBSC) mobilization strategies have been employed, granulocyte-colony stimulating factor (G-CSF) with or without plerixafor is widely utilized for its efficacy, safety and cost. To date, the recombinant G-CSF known as tbo-filgrastim has not compared to traditionally used filgrastim of PBSC engraftment after autologous transplantation (ASCT). Therefore, we sought compare efficacy cost during engraftment. Patients lymphoma plasma disorders undergoing...
Abstract Background Hematopoietic stem cell transplant (HSCT) patients develop profound neutropenia during the process and often fever, which is suggestive of infection. Antimicrobial prophylaxis (AP) anticipated recommended; however, data regarding when to initiate AP limited. A local quality improvement initiative adjusted initiation target duration severe neutropenia, defined as ANC ≤ 500 mm3 (ANC500), are at greatest risk This aimed reduce antimicrobial utilization consequences...
Background More than approximately 80% of hematopoietic stem cell transplant (HSCT) patients develop neutropenic fever warranting anti-Pseudomonal therapy (APT). Although Pseudomonas is not the most common pathogen causing febrile neutropenia, APT guideline-recommended because poor prognosis associated with infection. Moreover, less 20% these events result in positive blood cultures (BCx) as may be due to non-infectious etiologies. The T2Bacteria Panel (T2BP) provides rapid whole analysis...
Background Hematopoietic stem cell transplantation (HSCT) recipients often develop profound neutropenia and are ultimately at an increased risk of developing life-threatening infections peri-engraftment. There is discordance in the current guidelines for antibacterial prophylaxis (AP) patients undergoing HSCT. While ASTCT, formerly ASBMT, suggest beginning on day infusion, NCCN ASCO/IDSA recommend time neutropenia. These recommendations timing antimicrobials unsubstantiated by any...