About
Contact & Profiles
A5035995676
Research Areas
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Inorganic Fluorides and Related Compounds
- Fluorine in Organic Chemistry
University of California, Berkeley
2017
Trifluoromethylation via broken C-F bonds Trifluoromethyl substituents are widely used in pharmaceutical research to tune the properties of drug candidates. Generally, they introduced intact through formation carbon-carbon bonds. Levin et al. discovered an unusual alternative mechanism, which borane abstracts fluoride from CF 3 group a gold complex. The activated 2 fragment can then bond wide variety other carbon added same center. Return liberates trifluoromethylated compound metal. This...
10.1126/science.aan1411
article
EN
Science
2017-06-23
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