A5001424349- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Psychedelics and Drug Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Blind Source Separation Techniques
- Neurotransmitter Receptor Influence on Behavior
- CCD and CMOS Imaging Sensors
- Olfactory and Sensory Function Studies
University of California, Santa Cruz
2016-2023
Abstract Psychological stress affects a wide spectrum of brain functions and poses risks for many mental disorders. However, effective therapeutics to alleviate or revert its deleterious effects are lacking. A recently synthesized psychedelic analog tabernanthalog (TBG) has demonstrated anti-addictive antidepressant potential. Whether TBG can rescue stress-induced affective, sensory, cognitive deficits, how it may achieve such by modulating neural circuits, remain unknown. Here we show that...
Upon degeneration of photoreceptors in the adult retina, interneurons, including bipolar cells, exhibit a plastic response leading to their aberrant rewiring. Photoreceptor reintroduction has been suggested as potential approach sight restoration, but ability deafferented cells establish functional synapses with is poorly understood. Here we use photocoagulation selectively destroy rabbits while preserving inner retina. We find that rods and cones shift into ablation zone over several weeks,...
Demixing signals in transcranial videos of neuronal calcium flux across the cerebral hemispheres is a key step before mapping features cortical organization. Here we demonstrate that independent component analysis can optimally recover neural signal content widefield recordings dynamics captured at minimum sampling rate 1.5×10 6 pixels per one-hundred millisecond frame for seventeen minutes with magnification ratio 1:1. We show set spatial and temporal metrics obtained from components be...
The prevalent use of antibiotics in pregnant women and neonates raises concerns about long-term risks for children's health, but their effects on the central nervous system is not well understood. We studied perinatal penicillin exposure (PPE) brain structure function mice with a therapeutically relevant regimen. used battery behavioral tests to evaluate anxiety, working memory, sensory processing, immunohistochemistry quantify changes parvalbumin-expressing inhibitory interneurons (PV+...
Recording neuronal group activity across the cortical hemispheres from awake, behaving mice is essential for understanding information flow cerebral networks. Video recordings of function comes with challenges, including optical and movement-associated vessel artifacts, limited references time series extraction. Here we present a data-driven workflow that isolates artifacts calcium patterns, segments independent functional units surface. Independent Component Analysis utilizes statistical...
Functional imaging of neural cell populations is critical for mapping intra− and inter−regional network dynamics across the neocortex. Recently we showed that an unsupervised machine learning decomposition densely sampled recordings cortical calcium results in a collection components comprised neuronal signal sources distinct from optical, movement, vascular artifacts. Here build supervised classifier automatically separates activity artifact components, using set extracted spatial temporal...