A5014512283- Autoimmune and Inflammatory Disorders
- Hidradenitis Suppurativa and Treatments
- Autoimmune Bullous Skin Diseases
- Apelin-related biomedical research
- Nuclear Receptors and Signaling
- Macrophage Migration Inhibitory Factor
- Urticaria and Related Conditions
- Body Contouring and Surgery
- Microscopic Colitis
- Drug-Induced Adverse Reactions
- Dermatological and COVID-19 studies
- Eosinophilic Disorders and Syndromes
- Pathogenesis and Treatment of Hiccups
University of Toronto
2024-2025
University of Manitoba
2023
Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS) is a rare but severe hypersensitivity reaction. This retrospective cohort study compared the efficacy of systemic corticosteroids, current first-line therapy, cyclosporine, an emerging alternative in pediatric DReSS patients. We analyzed 14 cases patients (<18 years) admitted to The Hospital for Sick Children between January 2016 September 2023. Five received while nine were treated corticosteroids. Cyclosporine treatment was...
Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. We investigate the role cytokine, macrophage migration inhibitory factor (MIF) in regulating HSL adipocyte hypertrophy. Extracellular MIF downregulates an autocrine fashion, by activating AMPK/JNK signaling pathway upon binding to its membrane receptor, CD74. WT mice fed high fat diet (HFD), as well overexpressing MIF, both had circulating levels showed suppression during development Blocking...
Inflammation is associated with lipolysis in adipose tissue. HSL a key enzyme mediating through augmenting hydrolysis of triglycerides and diacylglycerides. Our study found that the procytokine MIF has both transcriptional non-transcriptional effects on activating AMPK signaling pathway. The activated downregulates gene expression adipocytes. It also upregulates phosphorylation Ser565, an inhibitory site, leading to reduction active Ser563 phosphorylation. These mechanisms are operative...