A5061638000- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Reproductive biology and impacts on aquatic species
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetics, Aging, and Longevity in Model Organisms
- Environmental Toxicology and Ecotoxicology
- Carcinogens and Genotoxicity Assessment
- Zebrafish Biomedical Research Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Neuroendocrine regulation and behavior
- Per- and polyfluoroalkyl substances research
- Physiological and biochemical adaptations
- Sex and Gender in Healthcare
- Sperm and Testicular Function
- Heat shock proteins research
- Lipid Membrane Structure and Behavior
- Photoreceptor and optogenetics research
- Cholinesterase and Neurodegenerative Diseases
- Estrogen and related hormone effects
- Alzheimer's disease research and treatments
- Hormonal and reproductive studies
- Mass Spectrometry Techniques and Applications
- Microplastics and Plastic Pollution
- Chemical Analysis and Environmental Impact
- Prostate Cancer Treatment and Research
Örebro University
2015-2024
University of Gothenburg
2022-2024
University of Southern California
2015-2016
Per- and polyfluorinated alkyl substances (PFASs) are synthetic organofluorine compounds with unique stability accompanied hydrophobic lipophobic properties. Perfluorooctane sulfonate (PFOS) Perfluorooctanoic acid (PFOA) of high concern due to their wide application in consumer industrial products, extreme persistence, abundant occurrence the environment toxic effect humans animals. However, knowledge on molecular mechanisms toxicity effects reproduction output remain scarce. In this study,...
Mating behavior differ between sexes and involves gonadal hormones possibly sexually dimorphic gene expression in the brain. Sex steroids prostaglandin E2 (PGE2) have been shown to regulate mammalian sexual behavior. The present study was aimed at determining whether exposure sex prostaglandins could alter zebrafish mating successful spawning recorded following 17β-estradiol (E2), 11-ketotestosterone (11-KT), D2 (PGD2) PGE2 via water. qRT-PCR used analyze transcript levels forebrain,...
Abstract Transthyretin (TTR) is a homo-tetramer protein involved in the transport of thyroid hormone (thyroxine; T4) plasma and cerebrospinal fluid. Many pollutants have been shown to bind TTR, which could be alarming as disruption system can lead several physiological problems. It also indicated that monomerization tetramer destabilization monomer amyloidogenesis. compounds are identified stabilize leading inhibition amyloid fibril formation. Other known induce Among pollutants, per-...
The sex differentiation mechanisms in zebrafish (Danio rerio) remains elusive, partly because of the absence chromosomes but also process appears to depend on synchrony multiple genes and possibly environmental factors. Zebrafish gonadal development is initiated through immature oocytes. Depending signaling cues, about half individuals, juvenile ovaries degenerate or undergo apoptosis initiate testes while other maintains oogenic pathway. We have previously shown that activation NFκB...
Abstract The incorporation of brominated flame retardants into industrial and household appliances has increased their occurrence in the environment, resulting deleterious effects on wildlife. With increasing restraints available compounds, there been a shift to using that seen production alternative such as 1,2‐dibromo‐4‐(1,2 dibromoethyl) cyclohexane (TBECH), which detected environment. In previous silico vitro studies authors have shown TBECH can activate both human androgen receptor...
Heat shock factors (Hsfs) are transcription that regulate responses to heat and other environmental stimuli. Four (Hsf1-4) have been characterized from vertebrates date. In addition stress response, they also play important roles in development gametogenesis. Here, we study the fifth member of factor family, Hsf5, using zebrafish as a model organism. Mutant hsf5−/− males, generated by CRISPR/Cas9 technique, were infertile with drastically reduced sperm count, increased head size, abnormal...
Metals are essential for many physiological processes and ubiquitously present in the environment. However, high metal concentrations can be harmful to organisms lead stress diseases. The accumulation of transition metals environment due either natural or anthropogenic activities such as mining results contamination water soil environments. study used Caenorhabditis elegans evaluate gene expression an indicator response, following exposure collected from three different locations downstream...
Brain sex differentiation is a complex process, wherein genes and steroid hormones act to induce specific gender brain differentiation. Testosterone (T) derived from the gonads has been linked neural circuit modeling in sex-specific manner. Previously, we have shown that cyp17a1 knockout (KO) zebrafish low plasma androgen levels, display compromised male-typical mating behaviors. In this study, demonstrated treatment of KO males with T or 11-ketotestosterone (11-KT) sufficient rescue...
Plasticizers are commonly used in different consumer goods and personal care products to provide flexibility, durability elasticity polymers.Due their reported toxicity, the use of several plasticizers, including phthalates has been regulated and/or banned from market.Di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) is an alternative plasticizer that was introduced replace toxic plasticizers.Increasing global demand lack toxicity data safety assessment DINCH have raised concern human...
The amyloid precursor protein (APP) is a key player in Alzheimer`s disease (AD) and the of Aβ peptide, which generated by consecutive cleavages β- γ-secretases. Familial Alzheimer's (FAD) describes hereditary subgroup AD that represents low percentage cases with an early onset disease. Different APP FAD mutations are thought to have qualitatively different effects on its proteolytic conversion. However, few studies explored pathogenic putative physiological differences more detail. Here, we...
There is a growing concern for male reproductive health as studies suggest that there sharp increase in prostate cancer and other fertility related problems. Apart from lifestyle, pollutants are also known to negatively affect the system. In addition many compounds have been shown alter androgen signaling, several environmental disrupt signaling via binding receptor (AR) or indirectly affecting synthesis. We analyzed here molecular mechanism of interaction between human AR Ligand Binding...