A5071282830- Muscle activation and electromyography studies
- CAR-T cell therapy research
- Muscle Physiology and Disorders
- Amyotrophic Lateral Sclerosis Research
- Redox biology and oxidative stress
- Virus-based gene therapy research
- Chronic Lymphocytic Leukemia Research
- Cerebral Palsy and Movement Disorders
- Biochemical Acid Research Studies
- Sarcoma Diagnosis and Treatment
- Neuroscience and Neural Engineering
Massachusetts General Hospital
2024-2025
Virginia Tech
2018-2019
Biomedical Research Institute
2019
Carilion Clinic
2018
Summary Motor function deteriorates with advancing age, increasing the risk of adverse health outcomes. While it is well established that skeletal muscles and neuromuscular junctions ( NMJ s) degenerate effect aging on α‐motor neurons their innervating synaptic inputs remains largely unknown. In this study, we examined soma in spinal cord aged rhesus monkeys mice, two species vastly different lifespans. We found that, both species, retain size despite an accumulation large amounts cellular...
Abstract There is increased recognition that sensory neurons located in dorsal root ganglia (DRG) are affected amyotrophic lateral sclerosis (ALS). However, it remains unknown whether ALS-inducing factors, other than mutant superoxide dismutase 1 (SOD1 G93A ), directly affect neurons. Here, we examined the effect of TAR DNA-binding protein (TDP43 A315T ) on culture and vivo . In parallel, reevaluated expressing SOD1 We found cultured harboring either TDP43 or grow neurites at a slower rate...
In addition to driving contraction of skeletal muscles, acetylcholine (ACh) acts as an anti-synaptogenic agent at neuromuscular junctions (NMJs). this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects aging on NMJs muscles. To test hypothesis, analyzed muscle fibers from heterozygous transgenic mice with reduced expression vesicular transporter (VKDHet), which present approximately 30% less synaptic compared control mice. Because is...