A5076157457- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Attention Deficit Hyperactivity Disorder
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrhythmias and Treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Diabetes Management and Research
- Lipoproteins and Cardiovascular Health
- Acute Ischemic Stroke Management
- Hip and Femur Fractures
- Vitamin K Research Studies
- Bipolar Disorder and Treatment
- Pharmacovigilance and Adverse Drug Reactions
- Venous Thromboembolism Diagnosis and Management
- Microbial Community Ecology and Physiology
- COVID-19 and Mental Health
- Potassium and Related Disorders
- Helicobacter pylori-related gastroenterology studies
- Bone health and osteoporosis research
- Child and Adolescent Psychosocial and Emotional Development
- Dementia and Cognitive Impairment Research
- Pharmaceutical Practices and Patient Outcomes
- Long-Term Effects of COVID-19
University College London
2016-2025
University of Hong Kong
2016-2025
University College London Hospitals NHS Foundation Trust
2022-2025
Hong Kong Science and Technology Parks Corporation
2023-2025
University of California, Los Angeles
2023-2024
Yale University
2023-2024
Laboratory of Data Discovery for Health
2021-2023
Chinese University of Hong Kong
2017-2023
The Fourth People's Hospital
2023
The London College
2022
<h3>Importance</h3> The risk of osteoporotic fracture with dabigatran use in patients nonvalvular atrial fibrillation (NVAF) is unknown. <h3>Objective</h3> To investigate the vs warfarin NVAF. <h3>Design, Setting, and Participants</h3> Retrospective cohort study using a population-wide database managed by Hong Kong Hospital Authority. Patients newly diagnosed NVAF from 2010 through 2014 prescribed or were matched propensity score at 1:2 ratio follow-up until July 31, 2016. <h3>Exposures</h3>...
Previous studies have reported an extremely unbalanced global access to opioid analgesics. We aimed determine contemporary trends and patterns of analgesic consumption at the global, regional, national levels.We analysed pharmaceutical sales data 66 countries or regions from IQVIA-Multinational Integrated Data Analysis System database on analgesics between 2015 2019. Opioid was measured in milligram morphine equivalent per 1000 inhabitants day (MME 1000/day). The trend changes were estimated...
Objective To assess the potential association between prenatal use of antidepressants and risk attention-deficit/hyperactivity disorder (ADHD) in offspring.Design Population based cohort study.Setting Data from Hong Kong population electronic medical records on Clinical Analysis Reporting System.Participants 190 618 children born public hospitals January 2001 December 2009 followed-up to 2015.Main outcome measure Hazard ratio maternal antidepressant during pregnancy ADHD aged 6 14 years,...
Patients with attention-deficit/hyperactivity disorder (ADHD) are at an increased risk of attempting suicide. Stimulants, such as methylphenidate hydrochloride, the most common treatment for ADHD, but association between their therapeutic use and suicide is unclear.To investigate attempts.A population-based, electronic medical records database from Hong Kong Clinical Data Analysis & Reporting System was used to identify 25 629 individuals aged 6 years who were treated January 1, 2001,...
Lipid-modifying agents (LMAs) are increasingly used to reduce lipid levels and prevent cardiovascular events but the magnitude of their consumption in different world regions is unknown. We aimed describe recent global trends LMA explore relationship between country-level cholesterol concentrations.This cross-sectional ecological study monthly pharmaceutical sales data from January 2008 December 2018 for 83 countries IQVIA Multinational Integrated Data Analysis System total non-high-density...
The risk of birth and neurodevelopmental complications with prenatal exposure to antipsychotics is unclear.To evaluate the association between problems.This population-based cohort study included children born January 2001 2015 follow-up December 2019 who were identified by Hong Kong Clinical Data Analysis Reporting System. Pregnancies maternal antidepressant/lithium removed. Primary analyses compared gestationally exposed nonexposed individuals propensity score fine stratification....
Current guidelines recommend using direct oral anticoagulants (DOACs) over warfarin in patients with atrial fibrillation (AF), but head-to-head trial data do not exist to guide the choice of DOAC.To a large-scale comparison between all DOACs (apixaban, dabigatran, edoxaban, and rivaroxaban) routine clinical practice.Multinational population-based cohort study.Five standardized electronic health care databases, which covered 221 million people France, Germany, United Kingdom, States.Patients...
BackgroundTimely recognition and appropriate treatment of attention-deficit/hyperactivity disorder (ADHD) are essential to enhance long-term outcomes individuals with ADHD. This study aimed evaluate the multinational trends patterns ADHD medication consumption.MethodsIn this longitudinal trend study, we used pharmaceutical sales data from IQVIA-Multinational Integrated Data Analysis System between 2015 2019, covering 64 countries across world. Consumption rates were expressed as defined...
Concerns have been raised that the use of antipsychotic medication for people living with dementia might increased during COVID-19 pandemic.To examine multinational trends in drug prescribing before and pandemic.This network cohort study used electronic health records claims data from 8 databases 6 countries (France, Germany, Italy, South Korea, UK, US) individuals aged 65 years or older between January 1, 2016, November 30, 2021. Two each were included Korea US.The introduction...
To investigate the trends in consumption of benzodiazepines (BZDs) and Z-drugs at global, regional, national levels from 2008 to 2018, across 67 countries regions.This cross-sectional descriptive study investigated BZDs analyzed by global pharmaceutical sales data IQVIA-Multinational Integrated Data Analysis System database between 2018. Consumption was measured defined daily dose (DDD) per 1000 inhabitants day (DDD/TID). The were estimated using linear mixed models. Additional analyses...
Recent studies raised concerns about the increasing use of gabapentinoids in different countries. With their potential for misuse and addiction, understanding global consumption will offer us a platform to examine need any interventional policies. This longitudinal trend study utilised pharmaceutical sales data from 65 countries regions across world evaluate trends gabapentinoid between 2008-2018. The multinational average annual percentage change was +17.20%, increased 4.17 defined daily...
To estimate the effect of gabapentinoid treatment on self-harm. A population based self-controlled case series study. UK Clinical Practice Research Datalink Aurum database linked to Hospital Episode Statistics and Office for National databases. 10 002 adults (aged ≥18 years), with prescriptions, who had an incident event self-harm between 1 January 2000 31 December 2020. Individual censoring occurred date epilepsy, substance misuse, or cancer diagnosis. Crude incidence rates in different...
Electrohydrodynamic atomization (EHDA) is a key research area for producing micro and nano-sized structures. This process can be categorized into two main operating regimes: electrospraying particle generation electrospinning fibre production. Producing particles/fibres of the desired size or morphology depends on factors; properties polymeric solution used processing conditions including flow rate, applied voltage collection distance. In this work particle-fibre transition region was...
It is unclear whether anticoagulant type associated with the risk for osteoporotic fracture, a deleterious complication of anticoagulants among patients atrial fibrillation (AF).To compare fracture between anticoagulants.Population-based cohort study.Territory-wide electronic health record database Hong Kong Hospital Authority.Patients newly diagnosed AF 2010 and 2017 who received new prescription warfarin or direct oral (DOAC) (apixaban, dabigatran, rivaroxaban). Follow-up ended on 31...
Abstract Previous studies report an association between maternal diabetes mellitus (MDM) and attention-deficit/hyperactivity disorder (ADHD), often overlooking unmeasured confounders such as shared genetics environmental factors. We therefore conducted a multinational cohort study with linked mother–child pairs data in Hong Kong, New Zealand, Taiwan, Finland, Iceland, Norway Sweden to evaluate associations different MDM (any MDM, gestational (GDM) pregestational (PGDM)) ADHD using Cox...