A5009707367- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Neural dynamics and brain function
- Multisensory perception and integration
- Folate and B Vitamins Research
Massachusetts Eye and Ear Infirmary
2022-2024
Eaton (United States)
2024
Harvard University
2022-2023
Harvard University Press
2022
Neurons in sensory cortex exhibit a remarkable capacity to maintain stable firing rates despite large fluctuations afferent activity levels. However, sudden peripheral deafferentation adulthood can trigger an excessive, non-homeostatic cortical compensatory response that may underlie perceptual disorders including hypersensitivity, phantom limb pain, and tinnitus. Here, we show mice with noise-induced damage of the high-frequency cochlear base were behaviorally hypersensitive spared...
Parvalbumin-expressing inhibitory neurons (PVNs) stabilize cortical network activity, generate gamma rhythms, and regulate experience-dependent plasticity. Here, we observed that activation or inactivation of PVNs functioned like a volume knob in the mouse auditory cortex (ACtx), turning neural behavioral classification sound level up down over 20dB range. PVN loudness adjustments were "sticky", such single bout 40Hz stimulation sustainably suppressed ACtx responsiveness, potentiated...
ABSTRACT Sound perception is closely linked to the spatiotemporal patterning of neural activity in auditory cortex (ACtx). Inhibitory interneurons sculpt patterns excitatory ACtx pyramidal neuron activity, and thus play a central role sculpting sound. Reduced inhibition from parvalbumin-expressing (PV) inhibitory associated increased gain sound-evoked spike rates are well-established consequences aging sensorineural hearing loss. Here, we reasoned that changes PV-mediated would directly...
ABSTRACT Throughout the brain, neurons exhibit a remarkable capacity to maintain stable firing rates despite large perturbations in afferent activity levels. As an exception, homeostatic regulation of neural often fails adult auditory system after hearing loss. Cochlear deafferentation caused by aging or noise exposure triggers widespread hyperactivity, particularly cortex (ACtx), which underlies perceptual disorders including tinnitus and hyperacusis. Here, we show that mice with...