A5061712077- S100 Proteins and Annexins
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Leprosy Research and Treatment
- Immune Response and Inflammation
- Laser Applications in Dentistry and Medicine
- Research on Leishmaniasis Studies
- Mast cells and histamine
- Olfactory and Sensory Function Studies
- Allergic Rhinitis and Sensitization
- Phytochemistry Medicinal Plant Applications
- Medical and Biological Ozone Research
- Diet and metabolism studies
- Infectious Diseases and Tuberculosis
- Inflammatory Bowel Disease
- Essential Oils and Antimicrobial Activity
- Neurotransmitter Receptor Influence on Behavior
- Indoor Air Quality and Microbial Exposure
- Diet, Metabolism, and Disease
- Piperaceae Chemical and Biological Studies
- Hydrogen's biological and therapeutic effects
- Phytochemistry and Bioactive Compounds
- Bariatric Surgery and Outcomes
- Receptor Mechanisms and Signaling
- Pharmacological Effects of Medicinal Plants
Universidade Federal de Mato Grosso
2016-2025
Universidade de Brasília
2017-2024
Universidade de Cuiabá
2010-2023
Universidade de São Paulo
2006-2021
Universidade do Estado de Mato Grosso
2020
Universidade Federal de São Paulo
2002-2017
Creative Research Enterprises (United States)
2017
Hospital for Tropical Diseases
2017
Universidade Estadual Paulista (Unesp)
2001-2011
Associação Brasileira de Oncologia Veterinária
2011
Abstract The recent appreciation of the role played by endogenous counterregulatory mechanisms in controlling outcome host inflammatory response requires specific analysis their spatial and temporal profiles. In this study, we have focused on glucocorticoid-regulated anti-inflammatory mediator annexin 1. Induction peritonitis wild-type mice rapidly (4 h) produced expected signs inflammation, including marked activation resident cells (e.g., mast cells), migration blood-borne leukocytes,...
Abstract Retinoid X receptors (RXRs) are important transcriptional nuclear hormone receptors, acting as either homodimers or the binding partner for at least one fourth of all known human receptors. Functional nongenomic effects poorly understood; however, recently peroxisome proliferator-activated receptor (PPAR) \#947;, PPAR\#946;, and glucocorticoid have been found active in platelets. Human platelets express RXR\#945; RXR\#946;. RXR ligands inhibit platelet aggregation TXA2 release to...
We evaluated the role of estradiol and progesterone in allergic lung inflammation. Rats were ovariectomized (Ovx) and, 7 days later, sensitized with ovalbumin (OA) challenged after 2 wk inhaled OA; experiments performed 1 day thereafter. Ovx-allergic rats showed reduced cell recruitment into bronchoalveolar lavage (BAL) fluid relative to sham-Ovx rats, as was observed intact treated ICI-182,780. Estradiol increased number cells BAL whereas induced an additional reduction. Cells bone marrow...
Lung diseases constitute an important public health problem and its growing level of concern has led to efforts for the development new therapies, particularly control lung inflammation. Low Level Laser Therapy (LLLT) been highlighted as a non-invasive therapy with few side effects, but mechanisms need be better understood explored. Considering that pollution causes several harmful effects on human health, including inflammation, in this study, we have used formaldehyde (FA), environmental...
The balancing functions of pro/anti-inflammatory mediators the complex innate responses have been investigated in a variety experimental inflammatory settings. Annexin-A1 (AnxA1) is one mediator endogenous anti-inflammation, affording regulation leukocyte trafficking and activation many contexts, yet its role lung pathologies has scarcely investigated, despite being highly expressed cells. Here we applied bleomycin fibrosis model to AnxA1 null mice over 21-day time-course, monitor potential...
Introduction: The intake of a high-fat, high-fructose diet during childhood may lead to obesity, hepatic steatosis, and inflammation in adulthood. Objective: To investigate the effects on metabolism diets with various levels fat associated fructose drinks childhood. Methods: Male 21-days-old rats were divided into groups: Control (C, 16.3% kcal from lipids water); High-fat (HF, 45% drink); very high-fat (VHF, 60% drink). After 10 weeks, blood liver collected for biochemical, histological,...
Intestinal ischemia/reperfusion (IR) injury is a serious and triggering event in the development of remote organ dysfunction, from which lung main target. This condition characterized by intense neutrophil recruitment, increased microvascular permeability. IR also responsible for induction adult respiratory distress syndrome, most life-threatening form acute injury. The purpose this study was to investigate effect annexin-A1 protein as an endogenous regulator induced intestinal...
Orofacial clefts (OFCs) have complex and multifactorial etiologies. Periconceptional folic acid supplementation can significantly reduce the risk of OFC.To evaluate role folate other factors in preventing OFC by analyzing health socio-demographic data collected from a population sample.Retrospective case-control study which mothers with children or without were evaluated for following main parameters: nutritional factors, characteristics, pregnancy family history, use folate, counseling...
Fluctuations of estradiol and progesterone levels caused by the menstrual cycle worsen asthma symptoms. Conflicting data are reported in literature regarding pro anti-inflammatory properties progesterone. Female Wistar rats were ovalbumin (OVA) sensitized 1 day after resection ovaries (OVx). Control group consisted sensitized-rats with intact (Sham-OVx). Allergic challenge was performed aerosol (OVA 1%, 15 min) two weeks later. Twenty four hours challenge, BAL, bone marrow total blood cells...
Helicteres sacarolha A. St.- Hil. et al. popularly known in Brazil as 'semente-de-macaco', is widely employed the popular medicine many of parts alleviation symptoms ailments such peptic ulcer and inflammation. Up to present, there no study addressing gastroprotective activity hydroethanolic extract H. its possible mechanism actions.The (70%) (HEHs) was obtained by maceration. The assessed using gastric models induced acidified ethanol, piroxicam, water restraint stress mice rats at doses...
Piper umbellatum L. leaves, commonly found in the Amazon, Cerrado and Atlantic rain forest regions of Brazil, are widely used as a traditional medicine to treat gastrointestinal disorders inflammation, among others diseases. Also, previous scientific studies demonstrated that P. has gastroprotective anti-inflammatory activity. To investigate phytochemical profiles intestinal effect hydroethanolic extract (HEPu) leaf on ulcerative colitis rats. In this study, chemical composition HEPu was...
Copaifera malmei Harms (Fabaceae) is a plant that occurs in the central region of Brazil, where plant's leaves infusion popularly used to treat gastric ulcer and inflammatory diseases. This study was aimed investigate gastroprotective activity mode action plants' order establish scientific basis for such usage, assess its potential as source an anti-ulcer agent. Leaves extract (SIECm) prepared, freeze dried lyophilised. Its qualitative quantitative phytochemical constituents were...