A5086865802- Eicosanoids and Hypertension Pharmacology
- Free Radicals and Antioxidants
- Helicobacter pylori-related gastroenterology studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Fatty Acid Research and Health
- Organoselenium and organotellurium chemistry
- Gastroesophageal reflux and treatments
- Veterinary Equine Medical Research
- Inflammatory mediators and NSAID effects
- Veterinary Medicine and Surgery
- Urinary Bladder and Prostate Research
- Diet, Metabolism, and Disease
- Metabolism and Genetic Disorders
- Coenzyme Q10 studies and effects
- Biopolymer Synthesis and Applications
- Drug Transport and Resistance Mechanisms
- Diet and metabolism studies
- Genomics, phytochemicals, and oxidative stress
- Urticaria and Related Conditions
- Organic Chemistry Cycloaddition Reactions
- Peroxisome Proliferator-Activated Receptors
The University of Tokyo
2021-2024
5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE) is an eicosapentaenoic acid-derived lipid metabolite, which we previously detected in inflamed mouse colon. In this study, investigated the pathophysiological roles of 5,6-DiHETE murine colitis and its underlying mechanisms action, focusing on effects transient receptor potential vanilloid (TRPV) channel activity. Oral administration dextran sodium sulfate (DSS, 2%, for 4 days) caused colon inflammation, peaked day 7 gradually...
Early diagnosis of colorectal cancer is needed to reduce the mortal consequence by cancer. Lipid mediators play critical role in progression colitis and colitis-associated colon (CAC) some their metabolites are excreted urine. Here, we attempted find novel biomarkers urinary lipid metabolite a murine model CAC. Mice were received single administration azoxymethane (AOM) repeated dextran sulfate sodium (DSS). urine was measured liquid chromatography mass spectrometry collected perform...
5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE) is an eicosapentaenoic acid-derived newly discovered bioactive anti-inflammatory lipid mediator having diverse functions. Here, we assessed the potential of orally administered 5,6-DiHETE in promoting healing dextran sulfate sodium (DSS)-induced colitis mice. We measured plasma concentrations untreated mice before and 0.5, 1, 3, 6 h after its oral administration (150 or 600 μg/kg) Mice developed by DSS (2% drinking water for 4...
Background: Allergic conjunctivitis (AC) is a common ophthalmologic disorder that causes symptoms often reduces patient's quality of life (QOL). We investigated the effects eicosapentaenoic acid metabolite (±)5(6)-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic ((±)5(6)-DiHETE) on AC using mouse model. Methods: BALB/c mice were sensitized with two injections short ragweed pollen in alum, challenged fifth eyedrops. The clinical signs and tear volume evaluated at 15 min after final challenge....
Although feline idiopathic cystitis (FIC) distresses of many cats, its pathogenesis is unknown and the diagnosis challenging. Polyunsaturated fatty acids (PUFAs) are metabolized into various lipid mediators. Lipid mediators such as prostaglandins (PGs) modulate inflammation them excreted urine. Thus, investigation urinary profile may reveal help FIC. We collected urine samples from five FIC cats by spontaneous urination analyzed 158 types in urines using liquid chromatography-mass...
Introduction Idiopathic epilepsy (IE) and meningoencephalomyelitis of unknown origin (MUO) are common causes brain diseases leading to seizures in dogs. In this study, the concentrations 196 lipid metabolites nitrogen oxide (NO) production cerebrospinal fluid (CSF) plasma dogs with MUO or IE were measured using a LC-MS/MS NOx analyzer, respectively. Methods Nine clinically healthy 11 12 MUO, respectively, included study. Results Lipid analysis revealed variations levels four six CSF plasma,...
Allergic conjunctivitis (AC) causes eyelid swelling, redness, tearing and itching when mast cells release mediators such as histamine (His). We reported 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), metabolite of eicosapentaenoic acid, suppressed His-induced inflammation. investigated the therapeutic effect 5,6-DiHETE on AC.
In pharmacology textbooks, explanations are provided about the physiological activities of primarily five prostaglandins and thromboxane that mainly produced through activity cyclooxygenase from unsaturated fatty acid arachidonic acid, as well pharmacological actions SAIDs NSAIDs inhibit their metabolism. With advancement omics technologies, it has become evident not only these major lipid metabolites but also many other dependent on various substrates enzymes metabolized within body. When...
Although intake of ω-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) are well known to be beneficial for some cardiovascular inflammatory diseases, their action mechanism remains elusive. Recently, we revealed that a EPA-metabolite 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic (5,6-DiHETE) represents strong anti-inflammatory reaction in animal body. We originally found 5,6-DiHETE is produced rich mouse inflamed colon tissue the healing phase colitis....
Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammation with repeated remission and relapse. A new therapeutic strategy no adverse effect for IBD urgently needed. We previously found that concentration of 5,6-DiHETE, metabolite eicosapentaenoic acid, increased in colon tissue at healing stage dextran sulfate sodium (DSS)-induced colitis. further administration 5,6-DiHETE inhibited vascular hyperpermeability induced by histamine. In this study, we assessed the oral on DSS...