A5018647441- Evolution and Genetic Dynamics
- Evolutionary Game Theory and Cooperation
- Gut microbiota and health
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Plant and animal studies
- COVID-19 epidemiological studies
- Aquaculture disease management and microbiota
- Identification and Quantification in Food
- Mathematical and Theoretical Epidemiology and Ecology Models
Uppsala University
2021-2025
ETH Zurich
2018-2021
Leiden University
2018
Abstract Generalist bacterial predators are likely to strongly shape many important ecological and evolutionary features of microbial communities, for example by altering the character pace molecular evolution, but investigations such effects scarce. Here we report how predator-prey interactions alter evolution fitness, genomes phenotypic diversity in coevolving communities composed Myxococcus xanthus as predator Escherichia coli prey, relative single-species controls. We show evidence...
ABSTRACT Plasmids are the primary vectors of horizontal transfer antibiotic resistance genes among bacteria. Previous studies have shown that spread and maintenance plasmids bacterial populations depend on genetic makeup both plasmid host bacterium. Antibiotic can also be acquired through mutations in chromosome, which not only confer but result changes physiology typically a reduction fitness. However, it is unclear whether chromosomal affect interaction between To address this question, we...
<title>Abstract</title> Interspecies interactions can influence the physiology of competing species, shaping their long-term evolutionary trajectories. While role interspecific competition in community dynamics is well-documented, its impact on outcomes and underlying mechanisms less explored. Here, we investigate how interspecies affects antibiotic resistance evolution gut pathogen Salmonella enterica within synthetic microbial communities. Specifically, examine presence an competitor,...
Abstract Evolution of microbial traits depends on the interaction a species with its environment as well other coinhabiting species. However, our understanding evolution specific traits, such antibiotic resistance in complex environments is limited. Here, we determine role interspecies interactions dynamics nitrofurantoin (NIT) selection among Escherichia coli . We created synthetic two-species community comprised two variants E. (NIT susceptible and resistant) Bacillus subtilis minimal...
Microbial genotypes with similarly high proficiency at a cooperative behaviour in genetically pure groups often exhibit fitness inequalities caused by social interaction mixed groups. Winning competitors this scenario have been referred to as ‘cheaters’ some studies. Such interaction-specific inequalities, well exploitation (in which between increases absolute fitness), might evolve due selection for competitiveness the focal or arise non-adaptively pleiotropy, hitchhiking genetic drift. The...
Predator impacts on prey diversity are often studied among higher organisms over short periods, but microbial predator-prey systems allow examination of prey-diversity dynamics evolutionary timescales. We previously showed that Escherichia coli commonly evolved minority mucoid phenotypes in response to predation by the bacterial predator Myxococcus xanthus one time point a coevolution experiment now named MyxoEE-6. Here we examine frequencies across several MyxoEE-6 timepoints discriminate...
Previous work shows that a host’s resident microbial community can provide resistance against an invading pathogen. However, this is continuously changing over time due to adaptive mutations, and how these changes affect the invasion of communities remains poorly understood. To address knowledge gap, we used experimental evolution approach in synthetic Escherichia coli Salmonella Typhimurium investigate bacterium expressing virulent phenotype, i.e., colicin secretion, time. We show evolved...
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