A5101519230- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Protein Degradation and Inhibitors
- ATP Synthase and ATPases Research
- Cancer therapeutics and mechanisms
- Peptidase Inhibition and Analysis
- Cyclopropane Reaction Mechanisms
- Histone Deacetylase Inhibitors Research
- Glioma Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Heat shock proteins research
- Biotin and Related Studies
- Food Quality and Safety Studies
- Ginseng Biological Effects and Applications
- Asymmetric Synthesis and Catalysis
- Silk-based biomaterials and applications
- Bioactive natural compounds
- PARP inhibition in cancer therapy
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Genetics, Aging, and Longevity in Model Organisms
- Genetic Syndromes and Imprinting
- Neurobiology and Insect Physiology Research
University of Minnesota
2023-2025
Taipei Medical University
2020-2024
Academy of Scientific and Innovative Research
2019
Institute of Genomics and Integrative Biology
2019
Sri Sai University
2019
Government Medical College, Amritsar
2019
Central University of Punjab
2018
University of Central Punjab
2018
Structural analysis of tazemetostat, an FDA-approved EZH2 inhibitor, led us to pinpoint a suitable site for appendage with pharmacophoric fragment second-generation HSP90 inhibitors. Resultantly, magnificent dual EZH2/HSP90 inhibitor was pinpointed that exerted striking cell growth inhibitory efficacy against TMZ-resistant Glioblastoma (GBM) lines. Exhaustive explorations chemical probe 7 several revelations such as (i) compound increased apoptosis/necrosis-related gene expression, whereas...
The antibacterial agent Bio-AMS is metabolized in vivo through hydrolysis of the central acyl-sulfamide linker leading to high clearance and release a moderately cytotoxic metabolite M1. Herein, we disclose analogues designed prevent metabolism moiety steric hindrance or attenuation electrophilicity. Bio-9 was identified as metabolically stable analogue with single-digit nanomolar dissociation constant for biotin protein ligase (BPL) minimum inhibitory concentrations (MICs) against...
Microwave-assisted cyclocondensation of title compounds afforded unreported imidazo[1,2-<italic>a</italic>] quinoxaline and benzo[<italic>f</italic>]imidazo[1,5-<italic>a</italic>][1,3,5]triazepines in high yields.
Structural tailoring of the flavone framework (position 7) via organopalladium-catalyzed C–C bond formation was attempted in this study. The impact substituents with varied electronic effects (phenyl ring, position 2 benzopyran scaffold) on antitumor properties also assessed. Resultantly, efforts yielded a furyl arm bearing possessing 4-fluoro phenyl ring 2) (14) that manifested magnificent profile against Ishikawa cell lines mediated through dual inhibition PARP and tubulin [(IC50 (PARP1) =...
Abstract: Proteolysis Targeting Chimeras (PROTACs) technology has emerged as a promising strategy for the treatment of undruggable therapeutic targets. Researchers have invested great effort in developing druggable PROTACs; however, problems associated with PROTACs, including poor solubility, metabolic stability, cell permeability, and pharmacokinetic profile, restrict their clinical utility. Thus, there is pressing need to expand size armory PROTACs which will escalate chances pinpointing...
Transdermal drug delivery system can deliver the drugs through skin portal to systemic circulation at a predetermined rate and maintain clinically effective concentrations over prolonged period of time.Transdermal patch is medicated adhesive that placed on specific dose medication into bloodstream.Often, this promotes healing an injured area body.The advantage transdermal route other types such as oral, topical, intravenous, intramuscular, etc. provides controlled release patient.These offer...
PLP-dependent enzymes represent an important class of highly "druggable" that perform a wide array critical reactions to support all organisms. Inhibition individual members this family has been validated as therapeutic target for pathologies ranging from infection with Mycobacterium tuberculosis epilepsy. Given the broad nature activities within enzymes, we envisioned universally acting probe characterize existing and putative also includes necessary chemical moieties enable activity-based...
Abstract: Asymmetric reactions have made a significant advancement over the past few decades and involved production of enantiomerically pure molecules using enantioselective organocatalysis, chiral auxiliaries/substrates, reagents via controlling absolute stereochemistry. The laboratory synthesis an impure starting material gives combination enantiomers that are difficult to separate for chemists in medicine, chromatography, pharmacology, asymmetric synthesis, studies on structure-function...