A5101620378- Pelvic floor disorders treatments
- Cancer therapeutics and mechanisms
- Antimicrobial Peptides and Activities
- Italian Fascism and Post-war Society
- Machine Learning in Bioinformatics
- Diet, Metabolism, and Disease
- Social Sciences and Policies
- Click Chemistry and Applications
- Drug Transport and Resistance Mechanisms
- DNA and Nucleic Acid Chemistry
- Zoonotic diseases and public health
- Immunotherapy and Immune Responses
- Gender and Feminist Studies
- Anorectal Disease Treatments and Outcomes
- Chemokine receptors and signaling
- Multiple Myeloma Research and Treatments
- Hormonal Regulation and Hypertension
- SARS-CoV-2 and COVID-19 Research
- Eicosanoids and Hypertension Pharmacology
- Gender, Violence, Rights in Latin America
- Pelvic and Acetabular Injuries
- Vaccine Coverage and Hesitancy
- Italian Literature and Culture
- Microtubule and mitosis dynamics
- Biochemical and Structural Characterization
University of Salerno
2022-2025
In this paper we present the design, synthesis, and biological evaluation of a new series peptidomimetics acting as potent anti-SARS-CoV-2 agents. Starting from our previously described Main Protease (M
ROR1 kinase is an underexplored promising target for the development of novel anticancer drugs, being strongly expressed in several cancer cell lines, but poorly non‐tumor cells. This property, together with scarce number molecules effective against ROR1, led us to design and develop a research program aimed discovery new chemical entities able inhibit thus interfering its pro‐tumoral activity. Step‐by‐step silico studies guided synthesis para‐phenylenediamine‐based compounds. SPR CETSA...
Acute pancreatitis (AP) is a potentially life-threatening illness characterized by an exacerbated inflammatory response with limited options for pharmacological treatment. Here, we describe the rational development of library soluble epoxide hydrolase (sEH) inhibitors treatment AP. Synthesized compounds were screened in vitro their sEH inhibitory potency and selectivity, results rationalized means molecular modeling studies. The most potent studied pharmacokinetic profile, where compound 28...
Different molecular mechanisms contribute to the development of multidrug resistance in cancer, including increased drug efflux, enhanced cellular repair and alterations metabolism or targets. ABCG2 is a member ATP-binding cassette superfamily transporters that promotes inducing chemotherapeutic malignant cells. In this context, selective inhibitors might be suitable strategy improve chemotherapy efficacy. Thus, through multidisciplinary approach, we identified new inhibitor (8),...
Haspin is an emerging, but rather unexplored, divergent kinase involved in tumor growth by regulating the mitotic phase. In this paper, in-silico design, synthesis, and biological characterization of a new series substituted indoles acting as potent inhibitors are reported. The synthesized derivatives have been evaluated FRET analysis, showing very inhibition. Then, comprehensive in-cell investigation highlighted compounds 47 60 most promising inhibitors. These were challenged for their...
The aim of this study was to evaluate perioperative morbidity and shortterm efficacy TVT-Secur in treating female stress urinary incontinence. Data from 147 patients with urodynamic and/or occult SUI who were treated TVTsecur each single centre between 1st March 2007 31st December collected. In positioning the sling, 74.8% surgeons chose transobturator approach (110/147) remaining 25.2% retropubic one. 64.6% (95/147) urethral hypermobility cystocoele =<2° degree according...