A5100681503- Curcumin's Biomedical Applications
- Endoplasmic Reticulum Stress and Disease
- Extraction and Separation Processes
- Genomics, phytochemicals, and oxidative stress
- interferon and immune responses
- Phase Change Materials Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bauxite Residue and Utilization
- Chemical Synthesis and Characterization
- TGF-β signaling in diseases
- Metallurgy and Material Science
- Lipid metabolism and biosynthesis
- Drug-Induced Hepatotoxicity and Protection
- Recycling and Waste Management Techniques
- Immune Response and Inflammation
- Cultural and Historical Studies
- NF-κB Signaling Pathways
- Viral Infections and Outbreaks Research
- Protein Structure and Dynamics
- Bone Metabolism and Diseases
- Natural Fiber Reinforced Composites
- Advanced Glycation End Products research
- Diet, Metabolism, and Disease
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
Jeonbuk National University
2014-2025
Catholic University of Korea
2025
Lehigh University
2020-2025
Chonbuk National University Hospital
2021-2024
Dongguk University
2024
Soongsil University
2016-2019
DeSales University
2019
Cardiovascular Institute Hospital
2016
Korea Institute of Science and Technology
2000-2015
Yeungnam University Medical Center
2013
Hydrogen mass repartitioning (HMR) that permits time steps of all-atom molecular dynamics simulation up to 4 fs by increasing the hydrogen atoms has been used in protein and phospholipid bilayers simulations improve conformational sampling. Molecular input generation via CHARMM-GUI now supports HMR for diverse programs. In addition, considering ambiguous pH at bacterial outer membrane surface, different protonation states, either −2e or −1e, phosphate groups lipopolysaccharides (LPS) are...
Curcumin, a major active component of turmeric, has previously been reported to alleviate liver damage. Here, we investigated the mechanism by which turmeric and curcumin protect against carbon tetrachloride (CCl4)-induced injury in rats. We hypothesized that extract from CCl4-induced reducing oxidative stress, inhibiting lipid peroxidation, increasing glutathione peroxidase activation.Chronic hepatic stress was induced single intraperitoneal injection CCl4 (0.1 ml/kg body weight) into...
Interferon-induced transmembrane proteins (IFITM1, 2, and 3) are important antiviral that active against many viruses, including influenza A virus (IAV), dengue (DENV), Ebola (EBOV), Zika (ZIKV), severe acute respiratory syndrome coronavirus (SARS-CoV). IFITM exhibit specificity in activity, but their distinct mechanisms of action regulation unclear. Since S-palmitoylation cholesterol homeostasis crucial for viral infections, we investigated interactions with by photoaffinity cross-linking...
Interferon-induced transmembrane proteins (IFITMs) are S-palmitoylated in vertebrates that restrict a diverse range of viruses. IFITM3 particular engages incoming virus particles, prevents their cytoplasmic entry, and accelerates lysosomal clearance by host cells. However, how S-palmitoylation modulates the structure biophysical characteristics to promote its antiviral activity remains unclear. To investigate site-specific controls activity, we employed computational, chemical, approaches...
Enhanced sampling methodologies modifying underlying Hamiltonians can be used for the systems with a rugged potential energy surface that makes it hard to observe convergence using conventional unbiased molecular dynamics (MD) simulations. We present CHARMM-GUI Sampler, web-based tool prepare various enhanced simulations inputs user-selected collective variables (CVs). Sampler provides following nine methods: accelerated MD, Gaussian conformational flooding, metadynamics, adaptive biasing...
Manganese (Mn) is an important trace element present in human body, which acts as enzyme co-factor or activator various metabolic reactions. While essential amounts, excess levels of Mn brain can produce neurotoxicity, including idiopathic Parkinson’s disease (PD)-like extrapyramidal manganism symptoms. This study aimed to investigate the protective role polyphenolic extract Euphorbia supina (PPEES) on Mn-induced neurotoxicity and underlying mechanism neuroblastoma SKNMC cells Sprague-Dawley...
Background Engagement in stimulation activities by both parents can have synergistic effects on early childhood development (ECD). While the role of maternal is well known, association with paternal remains underexplored and inconsistent. The current study aimed to assess distribution different combinations explore their associations ECD context sub-Saharan Africa (SSA). Methods Using Multiple Indicator Cluster Surveys Demographic Health from 26 SSA countries, we included 69 637 children...
ABSTRACT Diacylglycerol O‐acyltransferase 1 (DGAT1) is an integral membrane protein that uses acyl‐coenzyme A (acyl‐CoA) and diacylglycerol (DAG) to catalyze the formation of triacylglycerides (TAGs). The acyl transfer reaction occurs between activated carboxylate group fatty acid free hydroxyl on glycerol backbone DAG. However, how two substrates enter DGAT1's catalytic chamber interact with DGAT1 remains elusive. This study aims explore structural basis substrate recognition by...
A recently studied endoplasmic reticulum (ER) stress regulator, Bax inhibitor-1 (BI-1) plays a regulatory role in mitochondrial Ca2+ levels. In this study, we identified ER-resident and mitochondria-associated ER membrane (MAM)-resident populations of BI-1. increased to lesser extent BI-1–overexpressing cells (HT1080/BI-1) than control cells, most likely as result impaired intake ability lower basal levels intra-ER Ca2+. Moreover, opening the Ca2+-induced permeability transition pore (PTP)...
Phase change materials (PCMs) have been used in various fields including the of buildings. In this research, mixed shape-stabilized PCMs (Mixed SSPCMs) were prepared by impregnating coconut oil and n-hexadecane into exfoliated graphite nanoplatelets (xGnP) through a vacuum impregnate method. Coconut is fatty acid ester PCM which relatively economical comparison to other PCMs, paraffin that has high latent heat capacity. Drawbacks include leakage liquid state low thermal conductivity resolved...
Hyperactivation of phosphoinositol 3-kinase (PI3K) has been suggested to be a potential mechanism for endoplasmic reticulum (ER) stress-enhanced airway hyperresponsiveness, and PI3K inhibitors have examined as asthma therapeutics. However, the regulatory linking ER stress related pathological signals in not defined. To elucidate these pathogenic pathways, we investigated influence selective PI3Kδ inhibitor, IC87114, on inflammation an ovalbumin/lipopolysaccharide (OVA/LPS)-induced model. In...
Abstract The outer membrane is a key virulence determinant of gram‐negative bacteria. In Yersinia pestis , the deadly agent that causes plague, protein Ail and lipopolysaccharide (LPS) 6 enhance lethality by promoting resistance to human innate immunity antibiotics, enabling bacteria proliferate in host. Their functions are highly coordinated. Here we describe how they cooperate promote pathogenesis. Using multidisciplinary approach, identify mutually constructive interactions between LPS...
Latent heat thermal energy storage using phase change materials (PCMs) is considered to be the method with most potential solve shortage problem. In this study, paraffin-based mixed shape-stabilized PCM (SSPCM) (PBMS) was made by vacuum impregnation method. The prepared PBMS added gypsum powder as a fine aggregate. experiment, n-hexadecane and n-octadecane used have latent capacities of 254.7 247.6 J/g, melting points 20.84 30.4 °C, respectively. an in vacuum, following manufacturing...
Abstract Diet-induced obesity is a major contributing factor to the progression of hepatic insulin resistance. Increased free fatty acids in liver enhances endoplasmic reticulum (ER) stress and production reactive oxygen species (ROS), both are directly responsible for dysregulation signaling. BI-1, recently studied ER regulator, was examined investigate its association with ROS resistance models. To induce resistance, BI-1 wild type knock-out mice were fed high-fat diet 8 weeks. The had...
Chalcone is a polyphenolic compound found abundantly in natural plant components. They have been acclaimed as potential antitumor compounds multiple tumor cells. However, not much attention has paid to elucidate its mechanism of action. Here, chalcone was demonstrated trigger endoplasmic reticulum (ER) stress-induced apoptosis through sulfonation IRE1α by ER-localized NADPH oxidase 4 (NOX4). IRE1α-sulfonation at cysteine residue shown induce "regulated IRE1α-dependent decay" (RIDD) mRNA...