A5068865701- Inflammatory mediators and NSAID effects
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactions of Organic Compounds
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Computational Drug Discovery Methods
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Estrogen and related hormone effects
- Molecular Sensors and Ion Detection
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Chemical Reaction Mechanisms
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Synthesis of heterocyclic compounds
- Cancer therapeutics and mechanisms
- Pharmacological Effects of Natural Compounds
- Cholinesterase and Neurodegenerative Diseases
- Organometallic Compounds Synthesis and Characterization
- Oxidative Organic Chemistry Reactions
Guru Nanak Dev University
2016-2025
Shree Guru Gobind Singh Tricentenary University
2024
Indian Institute of Management Amritsar
2013-2018
Guru Gobind Singh Medical College and Hospital
2018
Government Medical College, Amritsar
2010-2017
Government Medical College and Hospital
2010-2016
Centre of Advanced Studies
2015-2016
High Energy Materials Research Laboratory
2014
North Eastern Hill University
2013
University of Warwick
2007
Bergapten, a furanocoumarin derivative found in variety of medicinal plants, is documented to possess anti-inflammatory activity. However, whether bergapten useful alleviating the symptoms as well progress peripheral neuropathy not yet studied. The current investigation has been designed explore effect on vincristine-induced neuropathic pain. Rats were grouped normal, control (vincristine), gabapentin, and treated groups with five animals each group. Vincristine (100 μg/kg, i.p.) was...
Rationally designed conjugates of chrysin, indole, and barbituric acid were synthesized screened for their antiinflammatory activities through in vitro vivo experiments. Improved over the previously reported chrysin-indole-pyrazole also comparison to based COX-2 inhibitors, new compounds have displayed significantly better IC50 some them exhibited inhibition 5-LOX enzyme. For one test compounds, was 1 1.5 nM, respectively. Investigations Swiss Albino mice capsaicin induced paw lickings...
Rationally designed tetrahydropyrans (THPs) carrying one, two, or three aryl rings and other substituents were synthesized by the allylation of β-hydroxy ketones followed iodocyclization. It has been observed that compounds with one ring on THP are moderate inhibitors cyclooxygenase-1 (COX-1) (IC50 = 0.3 μM) cyclooxygenase-2 0.17 poor selectivity index (SI 2−3) for COX-2. The presence two enhanced their inhibitory activities COX-2 0.9−5.5 nM). Selectivity over COX-1 also increased 50−1900),...
Among the small peptides 2-31, (H)Gly-Gly-Phe-Leu(OMe) (30) reduced prostaglandin production of COX-2 with an IC50 60 nM relative to 6000 for COX-1. The 5 mg kg(-1) dose compound 30 rescued albino mice by 80% from capsaicin-induced paw licking and recovered it 60% carrageenan-induced inflammation. mode action targeting COX-2, iNOS, VGSC was investigated using substance P, l-arginine, veratrine, respectively, as biomarkers. interactions were supported isothermal calorimetry experiments...
Acridones carrying an appropriate substituent at N-10 showed significant fluorescence changes on interacting with ATP in HEPES buffer pH 7.2. The selectivity and sufficient binding of these probes could be useful for monitoring metabolic processes.
Background. Mother's milk is the best for babies. Protective and preventive role of breast was evaluated in this study by assessing relation type feeding duration hospital stay or morbidity. Methods. This prospective conducted a tertiary care 232 infants age group 14 weeks to 6 months formed sample. There are two groups infants, that is, one breastfed top fed infants. Statistical analysis done results were calculated up 95% 99% level significance find effect pattern on due various diseases...
On the basis of structural analysis dihydrofolate reductase (DHFR) (cocrystallized separately with NADPH, and trimethoprim), compounds 2 3 were optimized for inhibition DHFR. Appreciable tumor growth inhibitory activities over 60 human cell lines recorded. Combination syringaldehyde indole moieties in these two was rationalized by synthesis 4–7, 10, 11, which found to have less than 3. Further, UV–vis NMR spectral investigations showed significant interactions DHFR its catalytic activity...
Here, we report analgesic and anti-inflammatory activity of a series compounds obtained by appending 4-aminophenylmorpholin-3-one acyclic, cyclic, or heterocyclic moieties on 1,3,5-triazine. The structures 4b 6b are optimized for the best inhibition COX-2 with IC50 values 0.06 0.08 μM, respectively, selectivity over COX-1 166 >125, respectively. At dose 5 mg kg–1, these significantly reduced acetic acid induced writhings, their ED50 were found to be 2.2 1.9 Besides cell-based animal-based...
The current investigation was aimed at in vivo MAOA inhibitory activity of coumarins angelicin, bergapten, and scopoletin isolated from the roots Angelica archangelica. compounds were screened for (pdb ID 2Z5y) binding through molecular docking studies. results displayed that bergapten has a maximum affinity MAOA, followed by angelicin scopoletin. In silico prediction physicochemical parameters indicated blood-brain barrier (BBB) permeability observed with (2.3), (2.0) least (0.644)....
An ADP selective fluorescent probe working in aqueous medium was identified and the change fluorescence as a function of concentration standardized. Using this probe, all steps glycolysis coupled with ATP/ADP inter-conversion oxidative breakdown pyruvate mitochondria were monitored consumption/production at each step quantified. The quantity present mitochondria, taken from different body parts pig, also determined. It is hypothesized that an appropriate modification technique may provide...