A5088840740- Birth, Development, and Health
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Chemical Synthesis and Analysis
- Colorectal Cancer Screening and Detection
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Health Promotion and Cardiovascular Prevention
- Clinical practice guidelines implementation
- Stress Responses and Cortisol
University of California, Irvine
2021-2024
Qatar University
2018
ConspectusThe Human Genome Project ultimately aimed to translate DNA sequence into drugs. With the draft in hand, Molecular Libraries Program set out prosecute all genome-encoded proteins for drug discovery with automated high-throughput screening (HTS). This ambitious vision remains unfulfilled, even while innovations sequencing technology have fully democratized access genome-scale sequencing. Why? While central dogma of biology allows us chart entirety cellular metabolism through...
Abstract Intergenerational trauma increases lifetime susceptibility to depression and other psychiatric disorders. Whether intergenerational transmission is a consequence of in-utero neurodevelopmental disruptions versus early-life mother–infant interaction unknown. Here, we demonstrate that exposure during pregnancy induces in mouse offspring social deficits depressive-like behavior. Normal pups raised by traumatized mothers exhibited similar behavioral those induced their biological...
Small molecule probes exist for only ∼2% of human proteins because most lack functional binding pockets or cannot be assayed high-throughput screening. Selective translation modulation circumvents canonical druggability and assay development constraints by using in vitro transcription-translation (IVTT) as a universal biochemical screening assay. We developed an IVTT activity fusing GFP reporter to various target gene sequences screened the inhibitors microfluidic picoliter-scale droplets...
Abstract Intergenerational stress increases lifetime susceptibility to depression and other psychiatric disorders. Whether intergenerational transmission is a consequence of in utero neurodevelopmental disruptions vs early-life mother-infant interaction largely unknown. Here, we demonstrated that exposure traumatic mice during pregnancy, through predator scent exposure, induces the offspring social deficits depressive-like behavior. We found, cross-fostering experiments, raising normal pups...