A5078714192- Transgenic Plants and Applications
- CRISPR and Genetic Engineering
- Plant tissue culture and regeneration
- Viral Infectious Diseases and Gene Expression in Insects
- Chromosomal and Genetic Variations
- Toxin Mechanisms and Immunotoxins
- RNA and protein synthesis mechanisms
- Model-Driven Software Engineering Techniques
Maastricht University
2014-2022
RWTH Aachen University
2018
Plants offer fast, flexible and easily scalable alternative platforms for the production of pharmaceutical proteins, but differences between plant mammalian N-linked glycans, including presence β-1,2-xylose core α-1,3-fucose residues in plants, can affect activity, potency immunogenicity plant-derived proteins. Nicotiana benthamiana is widely used transient expression recombinant proteins so it desirable to modify endogenous N-glycosylation machinery allow synthesis complex N-glycans lacking...
The yield of recombinant proteins in plants determines their economic competitiveness as a production platform compared to microbes and mammalian cells. promoter, untranslated regions (UTRs) codon usage can all contribute the yield, but potential interactions among these components have not been examined detail. Here effect two promoters (35SS nos) four 5'UTRs on spatiotemporal expression DsRed mRNA accumulation protein during transient tobacco (Nicotiana tabacum) mediated by Agrobacterium...