A5052721644- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Diet and metabolism studies
- Healthcare Systems and Practices
- Advanced MRI Techniques and Applications
- Metabolism and Genetic Disorders
- Cardiac Arrhythmias and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- Cardiac tumors and thrombi
- Cerebral Venous Sinus Thrombosis
- Metabolomics and Mass Spectrometry Studies
- Brain Metastases and Treatment
- Neurogenetic and Muscular Disorders Research
- Nanoparticle-Based Drug Delivery
- Vascular Malformations Diagnosis and Treatment
- Cardiovascular and Diving-Related Complications
Aix-Marseille Université
2023-2025
Inserm
2023-2025
Assistance Publique Hôpitaux de Marseille
2020-2025
Hôpital de la Timone
2022-2024
Hôpital Gui de Chauliac
2024
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2021-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023
Health and Education Research Management and Epidemiologic Services (United States)
2023
Université Côte d'Azur
2013-2021
Direction de la Recherche Fondamentale
2020-2021
<h3>Importance</h3> The best reperfusion strategy in patients with acute minor stroke and large vessel occlusion (LVO) is unknown. Accurately predicting early neurological deterioration of presumed ischemic origin (END<sub>i</sub>) following intravenous thrombolysis (IVT) this population may help to select candidates for immediate transfer additional thrombectomy. <h3>Objective</h3> To develop validate an easily applicable predictive score END<sub>i</sub>following IVT LVO. <h3>Design,...
The use of thrombectomy in patients with acute stroke and a large infarct unrestricted size has not been well studied.
The high risk of recurrence and comorbidity after a stroke associated with atrial fibrillation (AF) justifies an aggressive diagnostic approach so that anticoagulant treatment can be initiated.The clinical paraclinical characteristics consecutive ischemic patients without documented AF were recorded. Independent predictive factors then used to produce grading score for diagnosing AF, derived by logistic regression analysis: Score the Targeting Atrial Fibrillation (STAF).STAF, calculated from...
Patients with chronic kidney disease (CKD) have an increased risk of both ischaemic and haemorrhagic stroke compared the general population. Both acute impairment are independently associated poor outcome after onset a stroke, adjustment for confounders. End-stage (ESKD) is 7- 9-fold incidence strokes, respectively, poorer neurological 3-fold higher mortality. Acute injury (AKI) occurs in 12% patients 4-fold mortality unfavourable functional outcome. CKD seem to less access revascularisation...
Objectives Relationship between low-level air pollution and stroke is conflicting. This study was conducted to document the relationship outdoor ischaemic occurrence. Design Time-stratified case-crossover analysis. Setting University Hospital of Nice, France. Participants All consecutive patients with living in Nice admitted (France) January 2007 December 2011. Main outcome measure Association (adjusted OR) daily levels pollutants (ozone (O 3 ), nitrogen dioxide (NO 2 particulate matter...
The role of ketone bodies in the cerebral energy homeostasis neurological diseases has begun to attract recent attention particularly acute diseases. In ketogenic therapies, ketosis is achieved by either a diet or administration exogenous bodies. oral ingestion ester (KE), (R)-3-hydroxybutyl (R)-3-hydroxybutyrate, new method generate rapid and significant (i.e., above 6 mmol/L) humans. KE hydrolyzed into β-hydroxybutyrate (βHB) its precursor 1,3-butanediol. Here, we investigate effect (3 mg...
Whether bridging therapy (intravenous thrombolysis [IVT] followed by mechanical thrombectomy) is superior to IVT alone in minor stroke with basilar artery occlusion remains uncertain.Multicentric retrospective observational study of consecutive patients (National Institutes Health Stroke Scale score ≤5) intended for or therapy. Propensity-score weighting was used reduce baseline between-groups differences, and residual imbalance addressed through adjusted logistic regression, excellent...
Cerebral imaging is crucial in the diagnosis and treatment algorithm of acute stroke to determine salvageable brain tissue. While diffusion MRI commonly used define ischemic core, it cannot reliably distinguish irreversibly damaged from We investigated added value 23Na irreversible necrotic tissue after a stroke. Fifteen patients with involving medial cerebral artery occlusion were longitudinally explored conventional within 24 h, 70 h following at 3 months characterize area. Time-courses...
A case of multiple cerebral aneurysms caused by left atrial myxoma is reported.We present the details this and discuss hypothetical pathogenesis, radiological aspects treatment these neoplastic aneurysms.
<i>Background and Purpose:</i> Detecting paroxysmal atrial fibrillation (PAF) after ischaemic stroke is challenging. There are several methods to increase the detection rate of PAF, but it first necessary identify subgroups patients at risk. In a previous study, we established clinicoradiologic score that predicts (AF) in patients. The purpose present study validate this specifically for PAF <i>Methods:</i> 500 consecutive were examined our unit. A blind evaluation...
The diagnosis of cardioembolic stroke can be challenging for patient management in secondary prevention, particularly the case covert paroxysmal atrial fibrillation. molecular composition a cerebral thrombus is related to its origin. Therefore, proteomic and metabolomic analyses retrieved thrombotic material should allow identification biomarkers or signatures improve etiological stroke.In this pilot study, proteome metabolome thrombi from atherothrombotic patients were studied according...
Bradykinin-mediated angioedema (AE) is a complication associated with thrombolysis for acute ischemic stroke. Risk factors are unknown and management discussed.To clarify risk bradykinin-mediated AE after stroke.In case-control study conducted at French reference centre bradykinin angiœdema, patients stroke diagnosis of were compared to controls treated treatment without angiœdema.Fifty-three thrombolysis-related matched 106 control subjects. The sites attacks following mainly included...
<b><i>Background and Purpose:</i></b> Thrombin-activatable fibrinolysis inhibitor (TAFI) activation following thrombolysis may affect effectiveness in acute ischemic stroke (AIS). To support this hypothesis, we propose to study the relationship between TAFI consumption, activated/inactivated (TAFIa/ai) severity outcome 2 groups of AIS patients, one treated untreated with intravenous recombinant tissue type plasminogen activator (rt-PA)....
Acute ischemic strokes following surgical treatment of carotid stenosis lead to substantial disability and mortality, vascular mechanisms underlying their development are not fully elucidated. The goal this study was analyze the topographic patterns acute stroke endarterectomy (CEA) on diffusion-weighted perfusion-weighted magnetic resonance imaging (MRI).Data were retrospectively collected from consecutive patients who underwent CEA developed postoperative stroke. Based MRI data sets,...