A5020189594- Myasthenia Gravis and Thymoma
- Glycogen Storage Diseases and Myoclonus
- Gamma-ray bursts and supernovae
- Ion channel regulation and function
- Neural Networks and Applications
- Astrophysics and Cosmic Phenomena
- Renal Diseases and Glomerulopathies
- Microwave Engineering and Waveguides
- Cancer Treatment and Pharmacology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Machine Learning and Data Classification
- Spine and Intervertebral Disc Pathology
- Inflammatory Myopathies and Dermatomyositis
- Mathematical and Theoretical Epidemiology and Ecology Models
- Vasculitis and related conditions
- Astronomy and Astrophysical Research
- Bone Tumor Diagnosis and Treatments
- Eosinophilic Disorders and Syndromes
- Electromagnetic Compatibility and Noise Suppression
- Metabolism and Genetic Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Spinal Dysraphism and Malformations
- Immunodeficiency and Autoimmune Disorders
- Topic Modeling
- Musculoskeletal pain and rehabilitation
University of Illinois Urbana-Champaign
2020-2023
Pacific Northwest National Laboratory
2023
National Center for Supercomputing Applications
2021
Pain Management Institute
2015-2020
University of Cincinnati
2017
Mayo Clinic
1994-2015
WinnMed
1989-2015
Sahlgrenska University Hospital
2008-2015
University of Ferrara
2008-2015
Inserm
2008-2015
Time domain science has undergone a revolution over the past decade, with tens of thousands new supernovae (SNe) discovered each year. However, several observational domains, including SNe within days or hours explosion and faint, red transients, are just beginning to be explored. Here, we present Young Supernova Experiment (YSE), novel optical time-domain survey on Pan-STARRS telescopes. Our is designed obtain well-sampled $griz$ light curves for transient events up $z \approx 0.2$. This...
We present the Young Supernova Experiment Data Release 1 (YSE DR1), comprised of processed multi-color Pan-STARRS1 (PS1) griz and Zwicky Transient Facility (ZTF) gr photometry 1975 transients with host-galaxy associations, redshifts, spectroscopic/photometric classifications, additional data products from 2019 November 24 to 2021 December 20. YSE DR1 spans discoveries observations young fast-rising supernovae (SNe) that persist for over a year, redshift distribution reaching z~0.5. relative...
The modern study of astrophysical transients has been transformed by an exponentially growing volume data. Within the last decade, transient discovery rate increased a factor ~20, with associated survey data, archival and metadata also increasing number discoveries. To manage data at this rate, we require new tools. Here present YSE-PZ, management platform that ingests multiple live streams alerts, identifies host galaxies those transients, downloads coincident retrieves photometry spectra...
A number of myopathies whose common denominator is abnormal foci desmin positivity have been described under the rubrics spheroid body myopathy, cytoplasmic Mallory myopathy with granulofilamcntous inclusions, storage and intermediate filament myopathy. In this study we reevaluate light microscopic ultrastructural features positivity. 10 cases disease, analysis reveals 2 major types lesions: (a) myofibrillar destruction (b) hyaline structures that appear as spheroidal bodies on electron...
Immunocytochemical analysis of muscle specimens from 5 patients with acute quadriplegic myopathy indictes that depletion either fast or slow myosin occurs in this disorder. The initial lesion consists focal loss nonatrophic fibers. Other structural proteins (actin, titin, nebulin) are spared affected only at an advanced stage the disease. Attempts regeneration, evidenced by expression fetal and desmin, occur some Calpain is markedly enhanced fibers, implicating altered calcium homeostasis...
Cell adhesion molecules participate in target-effector cell interactions cell-mediated cytotoxicity and leukodiapedesis inflammatory diseases. Two ligand-receptor pairs may play a role the of cytotoxic T cells to their targets: 1) intercellular molecule-l (ICAM-1) lymphocyte function-associated antigen-1 (LFA-1), 2) LFA-3 CD2. We therefore immunolocalized these myopathies where there is evidence for myocytotoxicity, namely inclusion body myositis, polymyositis, Duchenne dystrophy....
Maltase (α-1,4-glucosidase) activity was determined at various pH values in tissues infantile (heart, liver, skeletal muscle), childhood and adult (liver, muscle, leukocytes) types of acid maltase deficiency (AMD) control tissues. In an case AMD, only traces neutral were present heart, this significantly decreased muscle liver. a No decreases occurred AMD An absolute decrease leukocyte found four relative one five adults with AMD. A the 4.0/pH 6.5 ratio may aid diagnosis
We describe a slowly progressive myopathy in 7 unrelated adult patients with storage of polyglucosan muscle fibers. Genetic investigation revealed homozygous or compound heterozygous deleterious variants the glycogenin‐1 gene ( GYG1 ). Most showed depletion skeletal muscle, whereas 1 presence lacking C‐terminal that normally binds glycogen synthase. Our results indicate either impaired interaction synthase underlies this new form disease differs from previously reported patient mutations who...
Abstract The slow‐channel congenital myasthenic syndrome (SCCMS) is caused by gain of function mutations in subunits the end‐plate acetylcholine receptor (AChR). prolong opening episodes AChR channel, leading to a depolarization block and an myopathy. Because levels quinidine sulfate attainable clinical practice shorten genetically engineered mutant SCCMS receptors vitro, we tested notion that drug can be benefit SCCMS. We treated 6 patients with open‐label trial, using objective measures...
We describe the genetic and kinetic defects in a congenital myasthenic syndrome caused by heteroallelic mutations of acetylcholine receptor (AChR) ε subunit gene. The are an in-frame duplication six residues long cytoplasmic loop (ε1254ins18) cysteine-loop null mutation (εC128S). ε1254ins18 causes mode switching kinetics activation which three modes activate slowly inactivate rapidly. ε1245ins18-AChR at endplate shows abnormally brief episodes during steady state agonist application appears...
We present GHOST, a database of 16,175 spectroscopically classified supernovae and the properties their host galaxies. have developed galaxy association method using image gradients that achieves fewer misassociations for low-z hosts higher completeness high-z than previous methods. use dimensionality reduction to identify distinguish supernova classes. Our results suggest SLSNe, SNe Ia, core collapse can be separated brightness information extendedness measures derived from host's light...
Muscle biopsies of a 7-week-old girl with profound weakness all but the ocular muscles, combined hypotonia, hyporeflexia, hepatomegaly, macroglossia, myopathic electromyogram, and slight elevation serum enzyme levels revealed mild glycogen marked lipid mitochondrial excess. Glycogen structure anaerobic glycolysis were normal. Aldolase pyruvate kinase relatively low lactic dehydrogenase isoenzyme pattern resembled that heart muscle. Subsequently patient had normal intellectual delayed motor...
We present Mantis Shrimp, a multi-survey deep learning model for photometric redshift estimation that fuses ultra-violet (GALEX), optical (PanSTARRS), and infrared (UnWISE) imagery. Machine is now an established approach estimation, with generally acknowledged higher performance in areas high density of spectroscopically identified galaxies over template-based methods. Multiple works have shown image-based convolutional neural networks can outperform tabular-based color/magnitude models. In...
Abstract The resemblance of the filamentous inclusions in inclusion body myositis (IBM) to mumps virus nucleoproteins and report immunoreactivity for antigens have implicated etiology IBM. We tested hypothesis by in‐situ hybridization with a cDNA probe specific nucleocapsid gene, immunocytochemically antibodies against “soluble” “viral” antigens. tests were performed on muscle specimens (IBM, 20; acid maltase deficiency, 4; chloroquine myopathy, 2; nonweak control subjects, 5) virus–infected...
Authors, readers, and editors share a common focus. Authors want to publish their work. Readers see high-quality, new information. Referees serve ensure that authors provide valid conclusions based on the quality of information readers want.Common each these roles are instructions authors. However, typically written in an uninspiring, legalistic style, as if they set rules must obey expect get published. This renders boring oppressive, not forbidding. Yet need be so, context.Instructions can...