A5025088612- Liver physiology and pathology
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Radiopharmaceutical Chemistry and Applications
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
Peking University
2023-2024
Peking University Cancer Hospital
2023-2024
Sialylated cancer IgG activates c-Met-SOX2 signaling to promote stemness properties in cells and can be targeted suppress tumor growth.
It is common knowledge that immunoglobulin (Ig) produced by B lymphocytes and mainly functions as an antibody. However, it has been shown recently myeloblasts from acute myeloid leukemia (AML) could also express Ig AML-Ig played a role in leukemogenesis AML progression. The difference between cells not explored. Studying the characteristics of repertoire will be helpful to understand function significance AML-Ig. We performed 5' RACE-related PCR coupled with PacBio sequencing analyze Chinese...
<p>Supplementary figures and tables.</p>
<p>Supplementary figures and tables.</p>
<div>Abstract<p>Elevated IgG expression in cancer cells has been implicated exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating need better understanding regulatory mechanisms control sialylated (SIA-cIgG). Here, we conducted genome-wide CRISPR activation screening identified OCT4 SOX2 as key factors promote SIA-cIgG expression. Functional...
<p>Supplementary figures and tables.</p>
<div>Abstract<p>Elevated IgG expression in cancer cells has been implicated exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating need better understanding regulatory mechanisms control sialylated (SIA-cIgG). Here, we conducted genome-wide CRISPR activation screening identified OCT4 SOX2 as key factors promote SIA-cIgG expression. Functional...
<div>Abstract<p>Elevated IgG expression in cancer cells has been implicated exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating need better understanding regulatory mechanisms control sialylated (SIA-cIgG). Here, we conducted genome-wide CRISPR activation screening identified OCT4 SOX2 as key factors promote SIA-cIgG expression. Functional...
<p>Supplementary figures and tables.</p>
<p>Supplementary figures and tables.</p>
<div>Abstract<p>Elevated IgG expression in cancer cells has been implicated exacerbated malignancy and poor clinical prognosis. Accumulating evidence indicates that a nonconventional sialylation modification is critical for the function of cancer-derived IgG, indicating need better understanding regulatory mechanisms control sialylated (SIA-cIgG). Here, we conducted genome-wide CRISPR activation screening identified OCT4 SOX2 as key factors promote SIA-cIgG expression. Functional...
<p>Supplementary figures and tables.</p>