A5063174027- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Transplantation: Methods and Outcomes
- Signaling Pathways in Disease
- Renal Transplantation Outcomes and Treatments
- Cardiac Fibrosis and Remodeling
- RNA Interference and Gene Delivery
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Nitric Oxide and Endothelin Effects
- Extracellular vesicles in disease
- Cardiac electrophysiology and arrhythmias
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Acute Myocardial Infarction Research
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Protein Kinase Regulation and GTPase Signaling
PAX Scientific (United States)
2023-2024
University of South Florida
2023
University of Michigan
2019-2022
Rhode Island Hospital
2016
Providence College
2016
There are conflicting reports on the role of reactive oxygen species (ROS) i.e. beneficial vs. harmful, in vascular endothelium. Here, we aim to examine whether duration exposure ROS and/or subcellular levels responsible for apparently paradoxical effects oxidants We have recently generated binary (Tet-ON/OFF) conditional transgenic mice (Tet-Nox2:VE-Cad-tTA) that can induce 1.8 ± 0.42-fold increase NADPH oxidase (NOX)-derived specifically endothelium upon withdrawal tetracycline from...
Increases in protein kinase C (PKC) are associated with diminished cardiac function, but the contribution of downstream myofilament phosphorylation is debated human and animal models heart failure. The current experiments evaluated PKC isoform expression, troponin I (cTnI) S44 (p-S44), contractile function failing (F) myocardium, rat dysfunction caused by pressure overload aging. In F elevated PKCα expression cTnI p-S44 developed before ventricular assist device implantation. Circulatory...
Abstract Introduction Endomyocardial biopsy (EMB)-based traditional microscopy remains the gold standard for detection of cardiac allograft rejection, despite its limitation inherent subjectivity leading to inter-reader variability. Alternative techniques now exist surveil injury and classify rejection. Donor-derived cell-free DNA (dd-cfDNA) testing is a validated blood-based assay used injury. The molecular microscope diagnostic system (MMDx) utilizes intragraft rejection-associated...