A5003485003- Pancreatic and Hepatic Oncology Research
- Legal Issues in South Africa
- Employer Branding and e-HRM
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Arts, Culture, and Music Studies
- Job Satisfaction and Organizational Behavior
- Glaucoma and retinal disorders
- Dam Engineering and Safety
- Corneal surgery and disorders
- Reservoir Engineering and Simulation Methods
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Underground infrastructure and sustainability
- Pancreatic function and diabetes
- Corneal Surgery and Treatments
- Public Administration and Political Analysis
- Organizational Leadership and Management Strategies
University of Johannesburg
2019
Sanford Burnham Prebys Medical Discovery Institute
2015-2017
Discovery Institute
2016-2017
University of California, San Diego
2015
Rotterdam Eye Hospital
2012
Netherlands Institute for Innovative Ocular Surgery
2012
Houston Advanced Research Center
2012
Pancreatic ductal adenocarcinoma (PDA) initiates from quiescent acinar cells that attain a Kras mutation, lose signaling basic helix-loop-helix (bHLH) transcription factors, undergo acinar-ductal metaplasia, and rapidly acquire increased growth potential. We queried whether PDA can be reprogrammed to revert their original cell state by shifting key programs.Human lines were engineered express an inducible form of the bHLH protein E47. Gene expression, growth, functional studies investigated...
// Nicholas Villarino 1 , Lia Signaevskaia Jaco van Niekerk Rachel Medal Heejung Kim Reyhaneh Lahmy Kathleen Scully Anthony Pinkerton 2 Sangwun 3 Andrew Lowy 4 and Pamela Itkin-Ansari 1, 5 Development, Aging Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA Conrad Center for Chemical Genomics, Division of Gynecologic Oncology, Department Obstetrics Gynecology, Institute Women's Life Science, Yonsei University College Medicine, Seoul, Republic Korea...
To report the outcomes of Descemet membrane endothelial keratoplasty (DMEK) using a large diameter graft in management decompensation buphthalmic eyes.Four eyes 4 adults (1 man, 3 women) with bullous keratopathy and buphthalmos secondary to congenital glaucoma were treated DMEK posterior lamellar grafts diameters ranging from 10 12 mm. The mean age was 31 (±9) years (range, 20-38 years). Mean follow-up time 13.5 (±7.5) months 6-24 months). Main outcome measures best-corrected visual acuity...
Orientation: The employer–employee relationship is becoming increasingly strained, evidenced by the increase in cases referred to Commission for Conciliation, Mediation and Arbitration. These disputes are presumed be a consequence of breach psychological contract undelivered expectations or obligations. There seems need improve management relationships.Research purpose: purpose this investigation was identify inducements obligations made known organisations on their websites.Motivation...
Abstract Pancreatic Ductal Adenocarcinoma (PDA) is the most lethal form of cancer with an average survival merely 6 months, underscoring need for new therapeutic approaches. A central feature PDA progression reduced expression and activity basic helix-loop-helix (bHLH) transcription factors. Recently, we showed that restoring bHLH in highly aggressive cells, through overexpression factor E47, resulted growth arrest tumorigenicity. Cell cycle exit was characterized by Aurora kinase A, cyclin...