A5009310136- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Urinary Bladder and Prostate Research
- Gut microbiota and health
- Cancer-related gene regulation
- Immune cells in cancer
- Immune Response and Inflammation
- RNA modifications and cancer
- Medicinal Plants and Bioactive Compounds
- Inflammatory Bowel Disease
- Mycobacterium research and diagnosis
- Medical Research and Treatments
- Epigenetics and DNA Methylation
- Pelvic floor disorders treatments
- Sexual function and dysfunction studies
Tangshan People's Hospital
2022
North China University of Science and Technology
2020
Background: The immune checkpoint inhibitors (ICIs) has dramatically changed the therapeutic area of cancers. A great number patients with CRC exhibit poor response rate to ICI treatment. N6-methyl adenosine (m6A) is closely correlated initiation and progression To explore role methyltransferase-like 16 (METTL16) in Methods: Clinical samples different cell lines were collected. expression METTL16 PD-L1 was determined by qPCR, IHC. Ectopic performed cells. co-culture system established using...
Ulcerative colitis (UC) is a main form of inflammatory bowel disease. Due to complicated etiology and high rate recurrence, it quite essential elucidate the underlying mechanism search for effective therapeutic methods UC.To investigate effects astragalus polysaccharides (APS) combined with matrine on UC associated lung injury.UC was induced in rats by colon mucosal tissue sensitization trinitro-benzene-sulfonic acid-ethanol. Then, treatments salazopyrine, APS, matrine, APS histopathological...
BACKGROUNDIntestinal inflammation is a common digestive tract disease, which usually treated with hormone medicines.Hormone medicines are effective to some extent, but long-term use of them may bring about many complications. AIMTo explore the protective effects panax notoginseng saponin (PNS) against dextran sulfate sodium (DSS)-induced intestinal inflammatory injury through phosphoinositide-3-kinase protein kinase B (PI3K/AKT) signaling pathway inhibition in rats. METHODSColitis rat models...
Objective. To investigate the efficacy of Panax notoginseng Ejiao suppository in patients with ulcerative proctitis and its effect on inflammatory response immune function. Methods. This study recruited 100 who were hospitalized to our hospital’s anorectal outpatient department between May 2015 October 2020. They randomly separated into either a control or group, 50 cases each. The group received mesalazine suppository, whereas suppository. Outcome measures included clinical effectiveness,...