A5090251942- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Bone health and treatments
- Bone and Joint Diseases
- Oral health in cancer treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- Oral Health Pathology and Treatment
- Cancer-related Molecular Pathways
- Tumors and Oncological Cases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Osteomyelitis and Bone Disorders Research
- Peptidase Inhibition and Analysis
- Infectious Diseases and Tuberculosis
- Oral and gingival health research
- Reconstructive Surgery and Microvascular Techniques
- Sarcoma Diagnosis and Treatment
- Dysphagia Assessment and Management
- Lung Cancer Treatments and Mutations
Hiroshima University
2022-2025
Hiroshima University Hospital
2022-2024
Nagasaki University
2014-2023
Nagasaki University Hospital
2015-2021
Kansai University
2020
Kansai Medical University
2020
Kyushu Dental University
2020
Shinshu University
2017
Fundación Juan March
2016
RELX Group (United States)
2014
ABSTRACT Medication-related osteonecrosis of the jaw (MRONJ) is an adverse event that may inhibit treatment primary disease and remarkably influence patient's quality life. The methods for MRONJ, nonsurgical surgical, are controversial, with no agreement as to which method provides best outcome should therefore be recommended. This multicenter retrospective study aimed investigate in a large number patients MRONJ Japan, utilizing propensity score matching analysis. A total 361 at eight...
The aim of this study was to investigate the effectiveness oral care in prevention postoperative pneumonia associated with esophageal cancer surgery. Postoperative is a severe adverse event It thought be caused by aspiration oropharyngeal fluid containing pathogens. However, relationship between health status and has not been well investigated. This included 539 patients undergoing surgery at 1 7 university hospitals. While 306 received perioperative care, 233 did not. Various clinical...
Abstract Tooth extraction has been avoided since it considered a major risk factor for medication-related osteonecrosis of the jaw (MRONJ). However, MRONJ may also develop from tooth that is an infection source. This study aimed to clarify whether development in cancer patients receiving bone-modifying agents (BMAs). retrospective observational included 189 (361 jaws) two hospitals. The factors were identified by comparing patient characteristics between those who did and not MRONJ....
Methods for preventing medication-related osteonecrosis of the jaw (MRONJ) in cancer patients who have received high-dose bisphosphonate (BP) or denosumab (Dmab) not yet been established. Tooth extraction after starting medication has believed to be a major risk factor MRONJ, and therefore this procedure tends avoided. This study investigated factors with special reference correlation between tooth development MRONJ. One hundred thirty-five were administrated BP Dmab enrolled study....
Abstract A multi‐institutional study was undertaken to determine whether mandibular canal ( MC ) invasion and medullary bone are independent factors in lower gingival squamous cell carcinoma SCC ). total of 345 patients with were retrospectively reviewed. Mandibular categorized into three types; no invasion; through cortical (medullary); invasion. The overall survival rate affecting local, regional, distant failures assessed by Cox proportional hazards regression analysis Kaplan–Meier...
Abstract Surgical site infection (SSI) is 1 of the frequent postoperative complications after colorectal cancer surgery. Oral health care has been reported to reduce risk SSI or pneumonia in oral, esophageal, and lung surgeries. The purpose study was investigate preventive effect perioperative oral management on development a major medical records 698 patients who underwent surgery at 2 hospitals Japan were reviewed. Among these patients, 563 received (oral group) 135 did not (control...
Abstract Background Topical 0.12% chlorhexidine has been used widely to prevent ventilator-associated pneumonia in patients undergoing mechanical ventilation. However, it is not approved for mucosal application Japan. The aims of this study were investigate if topical povidone iodine (i) inhibits bacterial growth and (ii) disrupts the balance oral microbiota. Methods This randomized controlled clinical trial included 23 who underwent ventilation intensive care unit. divided randomly into two...
The efficacy of neoadjuvant chemotherapy (NAC) is controversial, and no report supports NAC with a high evidence level. Recently, we showed that deep surgical margin was resected very close to the tumor site in many NAC-treated oral squamous cell carcinoma patients, suggesting may lead local recurrence poor outcomes. purpose this study evaluate effect on using cancer stem marker immunohistochemistry. We retrospectively analyzed 89 patients who underwent radical surgery for tongue cancer,...
The aim of this retrospective study was to assess the efficacy and safety cetuximab therapy for patients with locally advanced (LA) recurrent/metastatic (R/M) oral squamous cell carcinoma (OSCC), a specific focus on distant metastases (DMs). Data from 21 unresectable LA R/M OSCC treated in our department between December, 2012 July, 2015 were reviewed. endpoint time-to-progression assessments made tumor response rate, progression-free survival (PFS), overall (OS) safety. rate 57.1%, complete...
Keratoameloblastoma (KA) and solid variant of odontogenic keratocyst (SOKC) are rare lesions, their relationship differences unclear. The present study described a case that started as an (OKC) transformed to SOKC/KA upon recurrence. Briefly, 26‑year‑old man presented with swelling in the right cheek was referred Department Oral Maxillofacial surgery, Hiroshima University Hospital (Hiroshima, Japan). At initial visit, unicystic bone permeation observed extending from canine molar, maxillary...
Background and Objectives Some patients with early‐stage oral cancer have a poor prognosis owing to the delayed neck metastasis (DNM). Tumor budding is reportedly promising prognostic marker in many cancers. Moreover, tissue surrounding tumor also considered play role. In this study, we evaluated whether adjacent at invasive front can be potential novel predictors of DNM early tongue cancer. Methods total, 337 squamous cell carcinoma were retrospectively reviewed. The patient characteristics...
The aim of the present study was to identify most useful markers for predicting recurrence keratocystic odontogenic tumors (KCOTs). A total 65 tumor samples from 63 patients diagnosed with typical parakeratinized cysts and KCOTs between 1992 2014 were retrospectively studied. Clinical histopathological data treatment modality reviewed. In addition, expression profiles Ki-67, cluster differentiation (CD)34 podoplanin assessed using immunohistochemistry. association these factors rate KCOT...