Abstract Fe 3+ is a promising dopant for designing near‐infrared (NIR) phosphors due to its broadband emitting, non‐toxic, and inexpensive properties. However, the 4 E ( D) + A 1 G) levels of ions are independent crystal‐field parameter, spectral regulation has become huge challenge. Herein, NIR‐emitting phosphor Ca 2.5 Hf (Ga, Al) 3 O 12 : successfully developed toward long‐wave ultraviolet (LWUV) light‐pumped NIR phosphor‐converted LED (pc‐LED). Significantly, excited transition reverse Ga...

To research and develop potential phosphors for ultraviolet-based white light emitting diodes, a novel red emission phosphate phosphor Ca18Li3Bi1-xEux(PO4)14 was synthesized investigated in the full range of 0 ≤x≤ 1. The phase purity crystal structure solid solution were detail by employing X-ray diffractometer refinement, scanning electron microscopy energy dispersive spectrometry. information confirmed as well doping concentration dependent characteristic photoluminescence properties...

In this study, Lactiplantibacillus plantarum ATCC14917 was used to ferment Ganoderma lucidum spore powder. Two polysaccharides were purified from unfermented (GLP) and fermented (FGLP) The chemical structure antioxidant activity of the studied. Finally, effect GLP FGLP on oxidative stress regulation pathway in HepG2 cells explored. results showed that main structural characteristics remained unchanged during fermentation. However, average molecular weight (Mw) decreased 1.12 × 105 Da 0.89...

Abstract The burgeoning phosphor‐converted near‐infrared light‐emitting diodes (pc‐NIR LEDs) have important applications in special illumination and spectroscopy analysis. However, the development of efficient NIR‐emitting phosphors with high performance is still a challenge. In this work, chemical unit co‐substitution strategy proposed to realize excitation transition regulation successfully achieve high‐performance NIR luminescence Ca 3‐ y Na Mg 1‐ Sb 2‐ x Al 2+ O 12 : Cr 3+ (0 ≤ 0.05, 0...

Lipopolysaccharide (LPS) is ubiquitous in the environment. Recent epidemiologic data suggest that occupational exposure to inhaled LPS can contribute progression of chronic obstructive pulmonary disease. To address hypothesis cause emphysema-like changes mouse parenchyma, we exposed C57BL/6 mice aerosolized daily for 4 weeks. By 3 days after end 4-week exposure, LPS-exposed developed enlarged airspaces persisted recovered mice. These architectural alterations lung are associated with...

Bullous pemphigoid (BP) is an autoimmune skin-blistering disease characterized by the presence of autoantibodies against hemidesmosomal proteins BP230 and BP180. In IgG passive transfer mouse model BP, subepidermal blistering triggered anti-BP180 antibodies depends on complement system, mast cell (MC) degranulation, neutrophil infiltration. this study, we have identified signaling events that connect activation system MC degranulation. We found mice deficient in MCs or C5a receptor (C5aR)...

Abstract Cr 3+ ‐activated near‐infrared (NIR) emitting phosphors are considered as one of the most potential light‐conversion materials for NIR phosphor converted light‐emitting diodes (NIR pc‐LEDs). However, it is still a challenge single ion to achieve flat ultra‐broadband emission toward multi‐functional spectroscopy applications. Herein, chemical unit co‐substituting strategy utilized regulate crystallographic occupancy ions, and successfully realized with record wavelength 915 nm in...

Chronic lung diseases are marked by excessive inflammation and epithelial remodeling. Reduced Clara cell secretory function corresponding decreases in the abundance of major protein (CCSP) characteristically seen these disease states. We sought to define impact CCSP depletion on regulation inflammatory response. used chemical genetic mouse models deficiency (CCSP(-/-)) coupled with Pseudomonas aeruginosa LPS elicited inflammation. Exposure cell-depleted or CCSP(-/-) mice resulted augmented...

Abstract Exposure to ozone in air pollution urban environments is associated with increases pulmonary-related hospitalizations and mortality. Because also alters clearance of pulmonary bacterial pathogens, we hypothesized that inhalation modifies innate immunity the lung. To address our hypothesis, exposed C57BL/6J mice either free or ozone, then subsequently challenged an aerosol Escherichia coli LPS. Pre-exposure resulted enhanced airway hyperreactivity, higher concentrations both total...

Ozone exposure is associated with exacerbation of reactive airways disease. We have previously reported that the damage-associated molecular pattern, hyaluronan, required for complete biological response to ambient ozone and hyaluronan fragments signal through toll-like receptor 4 (TLR4). In this study, we further investigated role TLR4 adaptors in ozone-induced airway hyperresponsiveness (AHR) direct (HA). Using a murine model AHR, C57BL/6J, TLR4-/-, MyD88-/-, TIRAP-/- mice were...

Exposure to particulate matter (PM) is associated with acute cardiovascular mortality and morbidity, but the mechanisms are not entirely clear. In this study, we hypothesized that PM may activate angiotensin type 1 receptor (AT1R), a G protein-coupled regulates inflammation vascular function. We investigated effects of St. Louis, Missouri, urban particles (UPs; Standard Reference Material 1648) on constriction isolated rat pulmonary artery rings activation extracellular signal-regulated...

Particulate matter (PM) induces oxidative stress and cardiovascular adverse health effects, but the mechanistic link between two is unclear. We hypothesized that PM enhanced in vascular endothelial cells investigated enzymatic sources of reactive oxygen species their effects on mitogen-activated protein kinase (MAPK) activation vasoconstriction. measured production extracellular H 2 O , signal-regulated kinases1/2 (ERK1/2) p38 MAPKs human pulmonary artery (HPAEC) treated with urban particles...

The global incidence of dengue fever has increased significantly over the past two decades, and China faces a significant upward trend in control challenges.

Xiangwanxian 13 (XWX13), a fragrant indica rice variety with high yield and good grain quality, is generally welcomed by farmers in China. However, the fact that XWX13 highly susceptible to blast its cadmium (Cd) accumulation Cd polluted paddy fields has been limiting commercial utilization. Therefore, genomics-assisted selection approach was employed improve resistance lower accumulation. In this study, four major genes, namely Pi1, Pi2, OsHMA3 OsNramp5, were precisely introduced into KASP...

ABSTRACT Taxillus chinensis (DC) Danser ( T. ) is broadly used in traditional Chinese medicine. Although pharmacological research shows that the ethyl acetate extract of (JEA) has beneficial effects treating hyperuricemic nephropathy (HN), active components and potential mechanisms for these remain unclear. This study aims to predict effective mechanism JEA HN. Firstly, we adopted UHPLC‐Q‐Exactive HFXMS technology analyze chemical profile absorbed prototype ingredients rat plasma. In...

Epidemiology studies have linked exposure to pollutant particles increased cardiovascular mortality and morbidity, but the mechanisms remain unknown.We tested hypothesis that ultrafine fraction of ambient would cause endothelial cell dysfunction.We profiled gene expression human pulmonary artery cells (HPAEC) exposed (UFPs; 100 microg/mL) from Chapel Hill, North Carolina, or vehicle for 4 hr with Affymetrix HG U133 Plus 2.0 chips (n = each).We found 320 up-regulated genes 106 down-regulated...

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Exposure to pollutant particles increased respiratory morbidity and mortality. The alveolar macrophages (AMs) are one cell type in the lung directly exposed particles. Upon contact with particles, AMs activated produce reactive oxygen species, but scope of this oxidative stress response remains poorly defined. In study, we determined gene expression profile human sought characterize global pro- antioxidant genes. We obtained by bronchoscopy from normal individuals Chapel Hill particulate...

Inhalation of ambient ozone alters populations lung macrophages. However, the impact altered macrophage on pathobiology is poorly understood. We hypothesized that subpopulations macrophages modulate response to ozone. exposed C57BL/6 mice (2 ppm × 3 h) or filtered air. At 24 h after exposure, lungs were harvested and digested cells underwent flow cytometry. Analysis revealed a novel subset present in ozone-exposed mice, which distinct from resident alveolar identified by enhanced Gr-1(+)...

The tunable photoluminescence properties of (Ca,Sr)Hf₄(PO₄)₆:Eu²⁺ solid solution phosphors with high thermal stability and quantum efficiency were investigated.