A5101765306- Environmental and Agricultural Sciences
- Crop Yield and Soil Fertility
- Synthetic Organic Chemistry Methods
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Analysis
- Advanced Synthetic Organic Chemistry
- Forest, Soil, and Plant Ecology in China
- Diabetes Treatment and Management
- Receptor Mechanisms and Signaling
- Chemical synthesis and alkaloids
- Plant responses to water stress
- Fluorine in Organic Chemistry
- Plant Micronutrient Interactions and Effects
- Rice Cultivation and Yield Improvement
- Plant nutrient uptake and metabolism
- Plant Ecology and Soil Science
- Oxidative Organic Chemistry Reactions
- Remote Sensing and Land Use
- GABA and Rice Research
- Plant Stress Responses and Tolerance
- Mycobacterium research and diagnosis
- Agriculture, Soil, Plant Science
- Agricultural Science and Fertilization
- Organic Chemistry Cycloaddition Reactions
- Polymer-Based Agricultural Enhancements
Janssen (United States)
2015-2025
Johnson & Johnson (United States)
2005-2019
Springhouse
2019
Chinese Academy of Sciences
2005-2012
Northeast Institute of Geography and Agroecology
2009-2012
University of Chinese Academy of Sciences
2007-2009
China National Rice Research Institute
2008
Zhejiang University
2008
Heritage Christian University
2008
Harvard University
2001-2007
DEAD-box proteins comprise a large protein family with members from all kingdoms and play important roles in types of processes RNA metabolism. In this study, rice gene OsBIRH1, which encodes helicase protein, was cloned characterized. The predicted OsBIRH1 contains DEAD domain conserved motifs that are common characteristics helicases. Recombinant purified Escherichia coli shown to have both RNA-dependent ATPase ATP-dependent activities vitro. Expression activated seedling leaves after...
High-throughput screening of a subset the J&J compound library containing carboxylic acid functional group uncovered bromophenyl derivative as moderate potent GPR40 agonist. Chemical elaboration this led to discovery novel series agonists with submicromolar potency. Among them, 22 and 24 behaved full when compared endogenous ligand linolenic in Ca+2 flux assay HEK cells expressing receptor. Several have also demonstrated ability induce glucose-mediated insulin secretion mouse MIN6 pancreatic...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTComplete Structure of the MycolactonesSteve Fidanze, Fengbin Song, Magali Szlosek-Pinaud, P. L. C. Small, and Yoshito KishiView Author Information Department Chemistry Chemical Biology Harvard University, Cambridge, Massachusetts 02138 Microbiology, University Tennessee Knoxville, 37996 Cite this: J. Am. Chem. Soc. 2001, 123, 41, 10117–10118Publication Date (Web):September 19, 2001Publication History Received27 July 2001Published online19...
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTTotal Synthesis of the MycolactonesFengbin Song, Steve Fidanze, Andrew B. Benowitz, and Yoshito KishiView Author Information Department Chemistry Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 Cite this: Org. Lett. 2002, 4, 647–650Publication Date (Web):January 17, 2002Publication History Received20 December 2001Published online17 January 2002Published inissue 1 February...
[see structure]. A 16-step synthesis of the novel cytotoxin salicylihalamide (1E) has been achieved in 3.3% overall yield using ring closing metathesis to generate macrolide and addition (1Z,3Z)-hexadienylcuprate (2), which was generated situ from ethylcuprate acetylene, alkenyl isocyanate 3 form side chain.
Degradation-reconstruction approaches for isotope labeling synthesis have been known their remarkable efficiency, but applications are scarce due to some fundamental limitations of the chemistries developed date. The decarboxylative cyanation reaction, as a degradation-reconstruction approach, is especially useful in rapid carboxylic acid carbon labeling, however development toward its application widespread technique has stalled at early stages numerous which include somewhat narrow...
In Alzheimer's disease, the density and spread of aggregated tau protein track well with neurodegeneration cognitive decline, making imaging a compelling biomarker. A structure–activity relationship exploration around an isoquinoline hit, followed by tolerated fluorination positions, allowed us to identify 9 (JNJ-64326067), potent selective binder favorable pharmacokinetic profile no apparent off-target binding. This was confirmed in rat monkey positron emission tomography studies using [18F]9.
[reaction: see text] The unstable N-((1E)-alkenyl)-(2Z,4Z)-heptadienamide side chain of salicylihalamide A (1) and apicularens B (3 4) has been prepared in one pot by the addition (1Z,3Z)-hexadienylcuprate, situ from EtLi, CuBr.SMe2, acetylene, to a (1 E)-alkenyl isocyanate.
There is much evidence that direct inhibition of the kinase activity vascular endothelial growth factor receptor-2 (VEGFR-2) will result in reduction angiogenesis and suppression tumor growth. Palladium-catalyzed C-C bond, C-N bond formation reactions were used to assemble various pyrazine-pyridine biheteroaryls as potent VEGFR-2 inhibitors. Among them, 4-{5-[6-(3-chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-ylamino}-butan-1-ol (39)...
The first synthesis of (±)-anchinopeptolide D (4) has been accomplished in seven steps 10% overall yield from octopamine hydrochloride (17), N-(Boc)glycine (16), and 5-amino-2-hydroxypentanoic acid (22). key step is the aldol dimerization hemiaminal formation α-keto amide 26, which gives primarily protected anchinopeptolide 27 under kinetically controlled conditions. Cycloanchinopeptolide (31) prepared by unprecedented head-to-head photodimerization two hydroxystyrylamides 4 using...
Herein, we report a short, three-step synthesis of d-[1-(14) C]-serine (4) in high enantiomeric purity. Starting from [(14) C]-KCN and 2-(benzyloxy)acetaldehyde, Strecker reaction using (R)-1-phenylethylamine as the chiral auxiliary gave two diastereomeric aminonitriles 1 2 ratio 4:3, which were conveniently separated purified chromatographically. Following hydrolysis subsequent hydrogenolysis, major diastereomer 1, was smoothly converted to an excess >99%, thus circumventing time intensive...
ABSTRACT Carbon‐14 labeling synthesis of RORγt inhibitor JNJ‐61803534 ( 1 ) was accomplished in four steps with the C14 label located at thiazole‐2‐carboxamide carbon. The featured a highly efficient conversion nitrile [ 14 C]‐ 12 to ester 17 under mild conditions via an imidate intermediate, overcoming unsuccessful direct hydrolysis either acidic or basic conditions. Since carbon‐14 C]‐nitrile installation and subsequent C]‐carboxylic acid derivatives is common strategy, could be use for...