A5075708555- Dysphagia Assessment and Management
- Gut microbiota and health
- Parkinson's Disease Mechanisms and Treatments
- Statistical Methods and Bayesian Inference
- Pharmaceutical Practices and Patient Outcomes
- Optimal Experimental Design Methods
- Pharmacovigilance and Adverse Drug Reactions
- Ginger and Zingiberaceae research
- Patient Safety and Medication Errors
- Gastrointestinal motility and disorders
- Scientific Measurement and Uncertainty Evaluation
- Bayesian Methods and Mixture Models
- Advanced Statistical Process Monitoring
- Statistical Methods and Inference
- Child Nutrition and Feeding Issues
National Yang Ming Chiao Tung University
2011-2022
Over the past two decades, research into role of gut microbiome in regulating central nervous system has rapidly increased. Several neurodevelopmental diseases have been linked to unbalance microbiota, including autism. Children on autism spectrum often suffer from gastrointestinal symptoms, constipation, which is four times more prevalent than it children without disorders (ASD). Although studies animals shown crucial microbiota key aspects neurodevelopment, there currently no consensus how...
Abstract Background: Adverse drug events (ADE) have been studied widely in hospitalised and emergency department (ED) patients. Less is known about the ED visits of drug‐related injury Taiwan. This study seeks to determine incidence, risk patient outcomes ADE an population. Methods: We conducted a prospective observational cohort patients 18 years older presenting urban, tertiary medical centre. between 1 March 2009 28 February 2010 identified by investigators for suspected were further...
Background and Aims Parkinson’s disease (PD) is a worldwide neurodegenerative with an increasing global burden, while constipation important risk factor for PD. The gastrointestinal tract had been proposed as the origin of PD in Braak’s gut–brain axis hypothesis, there evidence indicating that intestinal microbial alteration has role pathogenesis In this study, we aim to investigate mechanism constipation-related Methods We adapted our data from Hill‐Burns et al., which 324 participants were...
Background and Aims Entacapone, one of the most common drugs distributed among patients with Parkinson’s disease, is a peripherally acting catechol-O-methyltransferase (COMT) inhibitor that used in addition to levodopa control symptoms. However, there have been negative effects reported against entacapone, namely, gastrointestinal (GI) problems drowsiness. In this pilot study, we aim examine hypothesis discomfort induced by entacapone might be originated from shift microbial composition...
Abstract Confidence intervals for the mean of discrete exponential families are widely used in many applications. Since missing data commonly encountered, interval estimation incomplete is an important problem. The performances existing multiple imputation confidence unsatisfactory. We propose modified to improve with quadratic variance functions. A simulation study shows that coverage probabilities closer nominal level than when true near boundaries parameter space. These also illustrated...
The proportion of conformance is defined as the products with quality characteristic inside specification limits. construction confidence interval for an important problem in industrial applications, especially when number conforming units follows a binomial distribution. In this study, we propose approach to construct intervals conformance. Numerical and simulation studies are conducted compare performance these intervals. addition, also provide methodology calculate exact coefficients...