A5024522405- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Infant Nutrition and Health
- Textile materials and evaluations
- RNA Interference and Gene Delivery
- Natural product bioactivities and synthesis
- Advanced Sensor and Energy Harvesting Materials
- Neuroinflammation and Neurodegeneration Mechanisms
- Building materials and conservation
- Mycorrhizal Fungi and Plant Interactions
- transportation and logistics systems
- Plant Pathogens and Fungal Diseases
- Life Cycle Costing Analysis
- Lipid Membrane Structure and Behavior
- Curcumin's Biomedical Applications
- Cultural Heritage Materials Analysis
- Conservation Techniques and Studies
- Phytochemical compounds biological activities
- Animal Virus Infections Studies
- Skin Protection and Aging
- Synthesis and Characterization of Heterocyclic Compounds
- SARS-CoV-2 and COVID-19 Research
- Additive Manufacturing and 3D Printing Technologies
- Immunotherapy and Immune Responses
- Plant-Microbe Interactions and Immunity
Wojskowy Instytut Higieny i Epidemiologii
2022-2025
Warsaw University of Life Sciences
2007-2025
(1) Background: Lactoferrin has been recognized as a potent inhibitor of human herpetic viruses, such herpes simplex type 1 (HSV-1) and 2 (HSV-2). In this work, we tested if silver gold nanoparticles modified with lactoferrin (LF-Ag/AuNPs) can become novel microbicides additional adjuvant properties to treat genital infection. (2) Methods: The antiviral cytotoxic activities LF-Ag/AuNPs were in skin HaCaT vaginal VK-2-E6/E7 keratinocytes. Viral titers immune responses after treatment murine...
(1) Background: Epigallocatechin gallate (EGCG) has been recognized as a flavonoid showing antiviral activity against various types of DNA and RNA viruses. In this work, we tested if EGCG-modified silver nanoparticles (EGCG-AgNPs) can become novel microbicides with additional adjuvant properties to treat herpes infections. (2) Methods: The anti-HSV cytotoxic activities EGCG-AgNPs were in human HaCaT VK-2-E6/E7 keratinocytes. HSV-1/2 titers immune responses after treatment murine models...
In this paper, we discuss the influence of ligand type present on surface silver nanoparticles (AgNPs) its affinity to virus and virucidal activity against herpes simplex 2 (HSV-2). We selected four different ligands, which potentially exhibit HSV-2 used them for functionalization AgNPs: i) sodium citrate: ii) tannic acid; iii) 1-mercaptoundecane-1-sulfonate (MUS); iv) poly(ethylene glycol) (PEG). The antiviral was performed by in vitro Vero cell culture. Anti- inflammatory measurement NF-κB...
Introduction: Herpes simplex virus type 1 (HSV-1) causes recurrent infections of skin and mucosal tissues with high global prevalence. HSV-1 also invades the nervous system where it establishes a lifelong latency-making infection poorly treatable We previously showed that both tannic acid-modified silver gold nanoparticles (TA-Ag/AuNPs) inhibit in vitro. Methods: used an vitro vivo model to study how metal type, size acid modification can influence development early innate response mounting...
Textile structures with various bioactive and functional properties are used in many areas of medicine, special clothing, interior textiles, technical goods, etc. We investigated the effect two different textile woven made 90% polyester 10% polyamide (PET) 100% cotton (CO) modified by magnetron sputtering copper (Cu) on against Gram-positive Gram-negative bacteria four viruses also some comfort parameters. PET/Cu CO/Cu fabrics have strong antibacterial activity Staphylococcus aureus...
Metallic nanoparticles exhibit broad-spectrum activity against bacteria, fungi, and viruses. The antiviral of results from the multivalent interactions with viral surface components, which result nanometer size material presence functional compounds adsorbed on nanomaterial surface. A critical step in virus infection process is docking entry into host cell. This stage can be influenced by nanomaterials that high affinity to hence disrupt process. tuned specific functionalization...
Abstract The antimicrobial functionalization of textile structures with copper and its compounds carried out by various methods increased significantly during the SARS-CoV-2 pandemic. So far, in order to obtain antiviral properties magnetron technique using was applied mainly flat structures; polypropylene, polyester cotton nonwovens, woven fabrics. In this study, sputtering modify spatial viscose needle-punched nonwoven fabric. We found that structure made regenerated cellulose fibers...
Abstract Intensive crop production leads to the disruption of symbiosis between plants and their associated microorganisms, resulting in suboptimal plant productivity lower yield quality. Therefore, it is necessary improve existing methods explore modern, environmentally friendly approaches production. One these biotization, which involves inoculation with appropriately selected symbiotic microorganisms play a beneficial role adaptation environment. In this study, we tested possibility using...
Plant polyphenols possess diverse bioactivities, including antiviral activity against a broad spectrum of viruses. Here, we investigated the virucidal properties an Kalanchoe daigremontiana extract using in vitro model human herpesvirus type 1 (HHV-1) infection. Chromatographic analysis indicated that is rich various compounds, among which are with confirmed literature. We found shows ability to prevent HHV-1 infection by direct inhibition virus attachment, penetration, and blocking when...
Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that causes persistent infection in sensory ganglia. The manifests itself as genital herpes but rare cases it can cause meningitis. In this study, we used murine model of HSV-2 meningitis to show Fas and FasL are induced within the CNS upon infection, both on resident microglia astrocytes infiltrating monocytes lymphocytes. Mice lacking or had more severe disease development with significantly higher morbidity, mortality,...