A5003112346- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Enterobacteriaceae and Cronobacter Research
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Infant Nutrition and Health
University of Helsinki
2021-2023
The global emergence and increased spread of antibiotic resistance threaten the effectiveness antibiotics and, thus, health entire population. Therefore, understanding resistomes in different geographical locations is crucial fight against crisis.
Infants are at a high risk of acquiring fatal infections, and their treatment relies on functioning antibiotics. Antibiotic resistance genes (ARGs) present in numbers antibiotic-naive infants' gut microbiomes, infant mortality caused by resistant infections is high. The role antibiotics shaping the resistome has been studied, but there limited knowledge other factors that affect antibiotic burden gut.Our objectives were to determine impact early exposure formula ARG load neonates infants...
The introduction of the first broad-spectrum antibiotics, sulfonamide drugs fundamentally revolutionized medicine in 1930s. Shortly after and ever since resistance genes (sul genes) have been widely detected. Still, most recent variant these sul4, was described only 2017 its host range transmission mechanisms are still largely unknown. Here we applied PacBio long-read metagenomic sequencing bacterial methylation signals to investigate genetic contexts carriage sul4 gene wastewater....
Abstract Antibiotic resistance is one of the greatest global threats to human health, but substantial gaps in antibiotic data exist West African countries. We explored presence genes (ARGs) hospital wastewater (HWW) nine hospitals Benin and Burkina Faso and, for comparison, four Finland using shotgun metagenomic sequencing. The highest sum relative abundance ARGs 68 HWW samples was detected lowest Finland. resistomes mobilomes resembled more each other than those Different carbapenemases...