A5085958856- Connexins and lens biology
- Nicotinic Acetylcholine Receptors Study
- Essential Oils and Antimicrobial Activity
- Heat shock proteins research
- Natural product bioactivities and synthesis
- Liver Disease Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
Lithuanian University of Health Sciences
2021-2024
Oslo University Hospital
2023
University of Oslo
2023
Institutt for Eksperimentell Medisinsk Forskning
2023
University of Copenhagen
2023
Essential oils from plants are a potential source of molecules having anti-inflammatory, anticancer, cardiotropic, and other activities. However, most these effects lack mechanistic explanations structure–activity relationship testing. In the present study, we: 1) identified nutmeg essential oil (NEO) composition; 2) using molecular docking, we determined putative regulatory binding sites on connexin 43 (Cx43) that is responsible for gap junction-dependent intercellular communication (GJIC)...
Physiological and pathological processes such as homeostasis, embryogenesis, development, tumorigenesis, cell movement depend on the intercellular communication through gap junctions (GJIC). Connexin (Cx)-based GJ channels are formed of two apposing hemichannels in contiguous cells provide a direct pathway for electrical metabolic communication. The main modulators conductance transjunctional voltage, intracellular pH, Ca
Gap junctions (GJs) made of connexin-43 (Cx43) are necessary for the conduction electrical impulses in heart. Modulation Cx43 GJ activity may be beneficial treatment cardiac arrhythmias and other dysfunctions. The search novel GJ-modulating agents using molecular docking allows accurate prediction binding affinities ligands, which, unfortunately, often poorly correlate with their potencies. objective this study was to demonstrate that a Quantitative Structure-Activity Relationship (QSAR)...
Gap junctions (GJs) made of connexin-43 (Cx43) are important for the conduction electrical impulses in heart. Modulation Cx43 activity may be useful treatment cardiac arrhythmias and other dysfunctions. Search novel GJ modulating agents using molecular docking approach allows to predict binding affinities that often significantly differ from experimentally estimated their potencies. The objective this study was demonstrate Quantitative Structure-Activity Relationship (QSAR) model could used...
Introduction: Sortillin-related VPS10P containing receptor (SorCS2) is expressed in neurons and other tissues during development where it mediates trafficking of target proteins between cell membrane intercellular compartments.It has also been suggested that SorCS2 modulates signal transduction.SorCS2 upregulated vascular wall under pathological conditions, e.g., atherosclerosis.The aim this study to elucidate the contribution endothelial smooth muscle function.Method: We compared mesenteric...