A5063187559- Connexins and lens biology
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Synthesis and biological activity
- Pancreatitis Pathology and Treatment
- Dendrimers and Hyperbranched Polymers
- Pain Mechanisms and Treatments
- Nanoparticle-Based Drug Delivery
- Antifungal resistance and susceptibility
- Diet, Metabolism, and Disease
- Fungal Infections and Studies
- Autophagy in Disease and Therapy
- HER2/EGFR in Cancer Research
- Heat shock proteins research
- COVID-19 Clinical Research Studies
- RNA regulation and disease
- Erythrocyte Function and Pathophysiology
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Chronic Myeloid Leukemia Treatments
- Ferrocene Chemistry and Applications
- Plant-Microbe Interactions and Immunity
Universidad Nacional Autónoma de México
2012-2024
Hospital General de México
2013
Nowadays, connexin (Cx) 36 is considered the sole gap junction protein expressed in pancreatic beta cells. In present research we investigated expression of Cx30.2 mRNA and mouse islets. were identified isolated islet preparations by qRT-PCR Western blot, respectively. Immunohistochemical analysis showed that insulin-positive cells stained for Cx30.2. Confocal images from double-labeled sections revealed Cx36 fluorescence co-localize at junctional membranes islets most pancreases. Abundant...
Abstract To identify when during fetal development connexins (Cxs) 26 (Cx26) 32 (Cx32), and 36 (Cx36) begin to be expressed, as well characterize their spatial distribution, real time polymerase chain reaction immunolabeling studies were performed. Total RNA from mouse pancreases at 13 18 days postcoitum (dpc) 3 postpartum (dpp) was analyzed. In addition, pancreatic sections of 13, 14, 15, 16, dpc dpp rat term double labeled with either anti‐insulin or anti‐α‐amylase anti‐Cx26 ‐Cx32 ‐Cx36...
Glucotoxicity may exert its deleterious effects on pancreatic β-cell function via a myriad of mechanisms, leading to impaired insulin secretion and, eventually, type 2 diabetes. communication requires gap junction channels be present among these cells. Gap junctions are constituted by transmembrane proteins the connexins (Cxs) family. Two Cx genes have been identified in β cells, Cx36 and Cx30.2. We found evidence that glucose concentration own is sufficient regulate Cx30.2 gene expression...
Background/Objectives: Doxorubicin (Dox) is an anticancer drug used in the treatment of a wide range solid tumors; however, Dox causes systemic toxicity and irreversible cardiotoxicity. The design new nanosystem that allows for control loading delivery results powerful tool to release only cancer cells. For this reason, supramolecular self-assembly was performed between poly(amidoamine) (PAMAM) dendrimer decorated with four β-cyclodextrin (βCD) units (PAMAM-βCD)...
Autophagy is a crucial mechanism for the functioning and survival of pancreatic beta cells. Its dysregulation has been associated with obesity, insulin resistance, glucose intolerance. Furthermore, decreased autophagy in insulin-secret ing cells reported to contribute devel opment type 2 diabetes mellitus (T2DM), which constitutes about 95% all cases chronic metabolic disease that it currently affects millions people around world. In different models rodents, whether diabetic or obese,...