A5101601860- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Hip and Femur Fractures
- Infectious Aortic and Vascular Conditions
- Tracheal and airway disorders
- Coronary Artery Anomalies
- Cardiovascular Issues in Pregnancy
- Viral Infections and Immunology Research
- HIV Research and Treatment
- interferon and immune responses
- Connective tissue disorders research
- Virus-based gene therapy research
- Moyamoya disease diagnosis and treatment
- Microbial bioremediation and biosurfactants
- Microplastics and Plastic Pollution
- Animal Disease Management and Epidemiology
- Cardiac tumors and thrombi
- Cancer-related molecular mechanisms research
- Bone and Dental Protein Studies
- Ferroptosis and cancer prognosis
Nantong University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Fudan University
2025
Huaiyin Institute of Technology
2023
Peking Union Medical College Hospital
2000-2022
Fu Wai Hospital
2012-2022
State Key Laboratory of Cardiovascular Disease
2013-2014
Rutgers, The State University of New Jersey
1994-1996
We have shown previously that the influenza virus NS1 protein inhibits nuclear export of mRNAs. Here we demonstrate also regulates another post-transcriptional step: It pre-mRNA splicing both in vivo and vitro. The mode by which is novel. forms spliceosomes, but subsequent catalytic steps are inhibited. Affinity selection experiments establish associated with spliceosomes formed. RNA-binding domain required for inhibition interaction spliceosomes. Because U6 snRNA virus-infected cells as...
The influenza virus NS1 protein is the only known example of a that inhibits nuclear export mRNA. To identify functional domains this protein, we introduced 18 2- or 3-amino-acid substitutions at approximately equally spaced locations along entire length protein. Two were identified. domain near amino end (amino acids 19 through 38) was shown to be RNA-binding domain, by using gel shift assay with purified and spliced viral NS2 mRNA as RNA target. second which in carboxy half molecule,...
Acute Type A aortic dissection exhibits poor in-hospital outcomes after emergency surgery. Evaluation of risk predictors for major adverse (MAO) is key to reducing the mortality rate and improving quality care.We enrolled 70 patients who presented with postoperative MAO 195 recovered well. Through univariate multivariate analyses, clinical characteristics were compared between in 2 groups.In-hospital was 6.4% this series. The group older had a higher frequency coronary artery involvement by...
Abstract OBJECTIVES Coronary-related technical complications constantly occur during type A aortic dissection surgical repair and are potentially fatal, yet their risk factors require further investigation. The intricate morphology of coronary ostial involvement may have a substantial impact. METHODS From June 2019 to January 2024, consecutive patients who underwent open surgery were included. Patients divided into the group (non-significant involvement: Neri A-dissected intima involving...
Type A aortic dissection (TAAD) is frequently complicated by concurrent coronary artery disease (CAD). This study aimed to evaluate the impact of concomitant bypass grafting (CABG) for CAD on short- and mid-term outcomes following TAAD surgical repair. retrospective, post-hoc analysis was conducted from June 2019 January 2024, involving 1,083 patients. Among them, 270 patients with were stratified into two groups based whether CABG performed: non-CABG groups. The inverse probability...
To retrospectively analyze the role of intercostal artery reconstruction in spinal cord protection for patients undergoing extensive thoracoabdominal aortic aneurysm repair.From August 2007 to 2014, aortas (Crawford II) 81 consecutive with mean age 39.4 ± 10.32 years were repaired. Seventy-three these (90.12%) diagnosed dissection our group, 25 (30.86%) Stanford type A and 48 (59.26%) B dissection. All have previously undergone surgical procedures which include Bentall's 11 cases, ascending...
Abstract Background Both bicuspid aortic valve (BAV) and bovine arch (BA) are considered as markers of thoracic disease (TAD). But the association between them is not yet clear. This study aimed to explore potential BAV BA with TAD. Methods The involved 449 participants who underwent their first replacement in Fuwai Hospital from June 2017 March 2018. All patients multidetector computed tomography echocardiography before surgery. clinical characteristics were recorded analyze BAV, BA,...
The optimal arterial cannulation site for acute aortic dissection repair is unclear, especially complex arch surgery. Axillary artery widely accepted but adding femoral to it was considered potentially improve perfusion and early outcomes. To clarify this point, a comparison of perioperative outcomes these two different strategies conducted regarding the pathological features dissection. From January 2010 December 2019, 927 consecutive patients underwent total replacement combined with...
Extracellular matrix disorder and cellular phenotype transformation are the major histopathological features associated with ascending aortic aneurysms. Rare studies have investigated relationship between abnormalities of constituents. In this study, we whether resulted in extracellular disorder.Aortic samples were obtained from 20 patients undergoing operations for Control 15 who underwent coronary artery bypass graft. The protein levels osteopontin (OPN), collagen, elastin examined using...
Aortic arch disease with Kommerell's diverticulum is an uncommon but troublesome condition, and there are a variety of therapeutic modalities for treating this. We retrospectively analyzed cases who underwent open surgery to summarize different situations approaches.From November 2015 January 2019, nine patients operation the mentioned disorder. Four aortic dissection received total replacement. Two suffering from type B (TBAD) have accepted graft replacement ascending aorta (aAO) descending...
Background: This study was aimed to investigate the incidence, risk factors, and outcomes of patients with postoperative hepatic dysfunction (PHD) after frozen elephant trunk (FET) for type A aortic dissection (TAAD). Method: retrospective performed 492 who underwent FET TAAD between 2015 2019. Independent factors PHD were determined by multivariate mixed-effect logistic analysis surgeon-specific factor as a random effect. Results: The incidence 25.4% (n = 125) in our cohort. Patients...
The purpose of this study was to assess the efficacy hybrid total arch procedure for treatment DeBakey type I dissection by analyzing mid-term results. From November 2009 September 2014, 56 patients with underwent repair without deep hypothermic circulatory arrest. During follow-up, computed tomographic imaging performed evaluate aortic diameter, true lumen false diameter and patency at following three levels: pulmonary bifurcation, diaphragm superior mesenteric artery. hospital mortality...
Abstract Background To introduce a new and simple classification management of coronary artery involvement in aortic dissection report results. Methods Coronary was classified into two types according to the integrity intima: lesion (type S) complex C). Complex lesions were treated by CABG ostial repair or reimplantation. Data collected analyzed retrospectively. Results From January 2010 December 2019, 267 consecutive patients enrolled study, among them occurred 27 (11.1%) found 240...
Due to better postoperative convalescence and quality of life, experienced centers focus on minimally invasive surgical techniques approaches, but this approach is not routinely performed for valve-sparing root replacement procedures. The purpose study was assess the safety feasibility via partial upper sternotomy. Between January 2016 April 2021, 269 patients underwent a procedure, sternotomy in 52 patients. clinical outcomes (PUS) complete (CS) groups, including mortality, degree aortic...
Kommerell diverticulum with aortic dissection involving arch is a rare but troublesome condition. The purpose of this study to summarize the experience and strategy surgical treatment.From November 2015 January 2018, seven consecutive patients underwent treatment in our institution. Three acute type A one patient B received total replacement frozen elephant trunk (FET) implantation through median sternotomy. chronic descending aorta sternotomy lateral thoracotomy.There were male whose age...