A5016740276- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Metal complexes synthesis and properties
- Computational Drug Discovery Methods
- Concrete Corrosion and Durability
- Corrosion Behavior and Inhibition
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Hydrogen embrittlement and corrosion behaviors in metals
- Chemical synthesis and pharmacological studies
- Organic Chemistry Cycloaddition Reactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Inorganic and Organometallic Chemistry
- Quinazolinone synthesis and applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Turkish Literature and Culture
- Synthesis and pharmacology of benzodiazepine derivatives
- Synthesis and Reactivity of Heterocycles
- Synthesis of Tetrazole Derivatives
- Treatment of Major Depression
- Synthesis of heterocyclic compounds
- Crystal structures of chemical compounds
Erciyes University
2016-2025
Sinop University
2024
Bozok Universitesi
2022
ABSTRACTIn here, a series of pyrimidin-(1(2H)-yl)acetamide and pyrimidin-(1(2H)-yl)isophthalimide derivatives were synthesised according to literature. The cytotoxic activity properties these molecules screened against human cancer cell lines as in vitro. results demonstrated that had moderate effects on for 48 h. binding potential the relatively active compound, ZF1, towards CDK1 (cyclin-dependent kinase 1) was investigated through molecular docking. stability enzyme-ZF1 complex procured...
Since Schiff base derivatives have a wide range of biological activities, novel were designed and synthesized in satisfactory yields. 1H NMR, 13C IR, mass elemental analysis used to provide complete structural characterization the new bases (3-6). The antiproliferative activity properties compounds tested against two human cancer cell lines including breast (MDA-MB-231) colon (DLD-1). overall did not show high cytotoxic both compared positive control drug cisplatin. further screened for...
Molecular modifications on sulfathiazole to overcome sulfonamide resistance: the discovery of selective antibacterial agents against <italic>Staphylococcus aureus</italic>.
Abstract In here, two new Schiff base molecules (3 and 4) were synthesized from the condensation reaction of 1‐amino‐5‐benzoyl‐4‐phenylpyrimidine‐2(1 H )‐one (1) 1‐amino‐5‐(4‐methylbenzoyl)‐4‐ p ‐tolylpyrimidin‐2(1 (2) with 4‐bromobenzaldehyde. These completely characterized by IR, NMR, HR‐MS. Moreover, molecule 4 was determined single crystal x‐ray diffraction (SC‐XRD) patterns. The crystallographic analysis revealed that crystallizes in monoclinic system, space group P2 1 /c. screened...
The discovery of new antimicrobial agents as a means treating drug-resistant microbial pathogens is utmost significance to overcome their immense risk human well-being. current investigation involves the development, synthesis, and assessment efficacy novel quinoline derivatives incorporating thiosemicarbazide functionality. To design target compounds (QST1-QST14), we applied molecular hybridization approach link various thiosemicarbazides core with sulfonyl group. Upon synthesis completion...
In this work, the effects of new compounds, namely, 1-amino-5-(4-methylbenzoyl)-4-(4-methylphenyl) pyrimidin-2 (1H)-thione (AMMP), and 1-(5-(4-Methoxybenzoyl)-4-(4-methoxyphenyl) 2-oxopyrimidin-1 (2H)-yl)-3-phenylthiourea (MMOPH) has been successfully investigated as a corrosion inhibitor for mild steel in 1 M HCl solution. This investigation done by electrochemical techniques (potentiodynamic polarization, impedance spectroscopy), surface characterization (scanning electron microscopy with...
Abstract In this study, a series of new Schiff bases, based on pyrimidine core, were synthesized in two steps. The structures these newly bases completely characterized. presence characteristic ‐N=CH proton peaks proving the formation imine supports compounds. cytotoxic activity studies done towards human cancer cell lines. results show that related molecules had antiproliferative cancerous cells. To compare chemical and biological activities derivatives performed using Gaussian software...
BACKGROUND: A pyrimidine based Schiff base was examined in this report.Structural and spectral characterizations were done with Gaussian software.Active sites of the compound determined using molecular electrostatic potential (MEP) maps.AIM: We focused to determine whether would be an inhibitor against Omicron SARS-CoV-2 silico.RESULTS AND CONCLUSION: As one perils world has seen lately, omicron SARS-CoV-2, is a complication solved.For sake that, anti-viral properties studied investigated...
In this paper, we present the results of pharmacophore identification and bioactivity prediction for pyrrolo[2,1-c][1,4]benzodiazepine derivatives using electron conformational-genetic algorithm (EC-GA) method as 4D-QSAR analysis. Using data obtained from quantum chemical calculations at PM3/HF level, conformational matrices congruity (ECMC) were constructed by EMRE software. The ECMC lowest energy conformer compound with highest activity was chosen template compared ECMCs other compounds...
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Abstract 1‐Aminopyrimidine‐2‐one derivatives ( 1a‐c ) were prepared in two steps from furan‐2,3‐diones and semicarbazones toluene/benzene. Pyrimidin‐[1(2 H )‐yl] acetamide isophthalimide synthesized the nucleophilic acyl substitution reactions of compounds with chloroacetyl chloride. The structures 2a‐f verified by IR , 1 NMR 13 C elemental analyses. obtained final organic tested as catalysts Mizoroki‐Heck coupling reaction. They mostly exhibited very high catalytic activity results for...
A series of the new 2-oxopyrimidin-1(2H)-yl-urea (3a-c) and thiourea (4a-d) derivatives were synthesized by reaction arylisocyanates (2a-c) or arylisothiocyanates (2d-g) 1-amino-5-(4-methoxybenzoyl)-4-(4-methoxyphenyl)pyrimidin-2(1H)-one (1). The structures compounds 3a-c 4a-d characterized elemental analysis, FT-IR, 1H 13C-NMR spectroscopic techniques. In addition to experimental study in order find molecular properties, quantum-chemical calculations carried out using DFT/B3LYP method with...