A5059472799- Sarcoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Soft tissue tumor case studies
- Uterine Myomas and Treatments
- Histiocytic Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Vascular Tumors and Angiosarcomas
- Bone Tumor Diagnosis and Treatments
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Cancer and Skin Lesions
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Oral and Maxillofacial Pathology
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Urologic and reproductive health conditions
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Surgical site infection prevention
- Bone fractures and treatments
- Thyroid Cancer Diagnosis and Treatment
- Soft tissue tumors and treatment
- Developmental Biology and Gene Regulation
- Genomics and Chromatin Dynamics
Kaiser Permanente
2020-2024
Kaiser Permanente Oakland Medical Center
2019-2024
Memorial Sloan Kettering Cancer Center
2017-2021
Colorado Permanente Medical Group
2021
Cleveland Clinic
2013-2019
Allegheny General Hospital
2017
Medpace (United States)
2017
Zealand University Hospital Køge
2017
Copenhagen University Hospital
2017
Rigshospitalet
2017
Abstract With the increasing use of next generation sequencing in soft tissue pathology, particularly neoplasms not fitting any World Health Organization (WHO) category, spectrum EWSR1 fusion-associated has been expanding significantly. Although recurrent EWSR1::ATF1 fusions were initially limited to a triad mesenchymal including clear cell sarcoma tissue, angiomatoid fibrous histiocytoma and malignant gastrointestinal neuroectodermal tumor (MGNET), this family expanding. We herein describe...
We recently encountered a case of primary pulmonary angiomatoid fibrous histiocytoma (AFH), which was initially misdiagnosed as inflammatory myofibroblastic tumor (IMT) based in part on anaplastic lymphoma kinase (ALK) expression by immunohistochemistry (IHC). Prompted this experience, we evaluated ALK 11 AFH, 15 IMT, and follicular dendritic cell sarcomas using 3 different antibody clones: D5F3, 5A4, ALK1. IHC positive cases were analyzed with fluorescence situ hybridization (FISH) dual...
Context.— Bone and soft tissue tumors are heterogeneous, diagnostically challenging, often defined by gene fusions. Objective.— To present our experience using a custom 34-gene targeted sequencing fusion panel. Design.— Total nucleic acid extracted from formalin-fixed, paraffin-embedded (FFPE) tumor specimens was subjected to open-ended, nested anchored multiplex polymerase chain reaction enrichment of 34 targets, thus enabling detection known novel partners. Results.— During 12-month...
β-catenin immunohistochemical stain can be useful in the diagnosis of many tumors including desmoid-type fibromatosis (DTF). Lymphoid enhancer-factor 1 (LEF1), a recently emerged marker, is part Wnt pathway with but has not been studied DTF. We performed LEF1 and immunohistochemistry DTF (n=26), superficial (n=19), sclerosing mesenteritis (n=12), gastrointestinal stromal tumor (n=17), cutaneous scar (n=14) using tissue microarray whole sections. The staining intensity was scored as strong...
Abstract Neuregulin 1 (NRG1) is an epidermal growth factor (EGF)‐like ligand that activates receptor tyrosine kinases of the ErbB family receptors. NRG1 gene fusions, which are rare (<1%) but recurrent events in solid tumors, emerging oncogenic driver potentially actionable using ErbB‐targeted kinase inhibitors. Largely characterized only carcinomas, we describe three cases NRG1‐ rearranged sarcomas. The patients were all female, aged 32–47 years old. Two deep‐seated tumors lower...
Background Epithelioid benign fibrous histiocytoma has been considered a variant of histiocytoma, but is now distinct entity, typically showing ALK expression. Most show typical morphological features, including an epidermal collarette and large, bland, epithelioid cells. We have recently encountered 2 examples unusual pattern pericellular calcification, previously unreported finding. Methods Available slides were reviewed clinical follow‐up was obtained. Results These lesions occurred on...
Involvement of the skeletal system by congenital syphilis is well documented in literature, chiefly form radiologic studies, including periostitis, osteitis, and osteochondritis. Because generally recognized clinically, tissue biopsy virtually never performed. Therefore, histopathologic findings are less mostly exist older literature. We report herein clinicoradiologic pathologic features a 2-month-old infant who initially presented with absence left arm movement. Radiographs humerus...
PURPOSE: Management of soft tissue and bone sarcoma presents many challenges, both diagnostically therapeutically, requires multidisciplinary collaboration; however, such collaboration is often challenging to establish, especially in the community setting. We share our experiences a virtual case conference (VMSCC). METHODS: conducted retrospective review VMSCC data—initially via Webex, now Microsoft Teams—and surveys referring physicians understand feasibility value VMSCC. RESULTS: The was...
High-grade neuroendocrine carcinoma (NEC) has been previously reported to arise within preexisting adenoma but is usually at an advanced stage and carries a dismal prognosis almost always treated with surgical resection. Intramucosal NECs polypectomy have not reported. Herein, we report the first case of intramucosal NEC by polypectomy. An 87-year-old white male was referred Cleveland Clinic for polyp detected in outside hospital. A 40 mm sessile visualized recto-sigmoid colon using flexible...
Management of soft tissue and bone sarcoma presents many challenges, both diagnostically therapeutically, requires multidisciplinary collaboration; however, such collaboration is often challenging to establish, especially in the community setting. We share our experiences a virtual case conference (VMSCC).We conducted retrospective review VMSCC data-initially via Webex, now Microsoft Teams-and surveys referring physicians understand feasibility value VMSCC.The was established March 2013...
Infantile myofibroma is a unique fibrous tumor encountered in the head and neck. Although majority of cases are solitary nodules that require only conservative management, awareness possibility multicentric disease important considering its substantial morbidity. A 3-month-old girl presenting with an enlarging 2.5-cm firm, mobile, nontender subcutaneous scalp mass was evaluated magnetic resonance imaging biopsy, revealing diagnosis infantile myofibroma. The literature reviewed for supporting...
High-grade neuroendocrine carcinoma (NEC) has been previously reported to arise within preexisting adenoma but is usually at an advanced stage and carries a dismal prognosis almost always treated with surgical resection. Intramucosal NECs polypectomy have not reported. Herein, we report the first case of intramucosal NEC by polypectomy. An 87-year-old white male was referred Cleveland Clinic for polyp detected in outside hospital. A 40 mm sessile visualized recto-sigmoid colon using flexible...
<h3>Objectives</h3> Rare low-grade endometrial stromal sarcomas (LGESS) may show high-grade morphology in primary or recurrent tumors. These lesions are classified as (HGESS), which general more aggressive and have higher rates of resistance to endocrine therapy than LGESS. The pathogenesis hormonal these tumors has yet be defined. Here we describe two endocrine-resistant HGESS with <i>ESR1</i>hotspot mutations. <h3>Methods</h3> For case 1, DNA from the estrogen receptor (ER)-positive LGESS...
OBJECTIVE: Rare low-grade endometrial stromal sarcomas (LGESS) may show high-grade morphology in primary or recurrent tumors. These lesions are classified as (HGESS), which general more aggressive and have higher rates of resistance to endocrine therapy than LGESS. The pathogenesis hormonal these tumors has yet be