A5003016719- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Respiratory and Cough-Related Research
- Gastroesophageal reflux and treatments
- Cancer-related gene regulation
Baotou Central Hospital
2025
Fujian Medical University
2024
Hangzhou First People's Hospital
2022
Seasonal allergic rhinitis (SAR) places a significant socioeconomic burden, particularly on individuals with poorly managed recurrent and severe symptoms despite standard-of-care treatment. Stapokibart, humanized monoclonal antibody that targets the interleukin (IL)-4 receptor subunit alpha, inhibits its interaction both IL-4 IL-13 in type 2 inflammation. Here we aim to assess efficacy safety of stapokibart as an add-on therapy adults moderate-to-severe SAR. The study was phase 3...
Anti-interleukin-4 receptor subunit alpha (IL-4Rα) treatments can effectively treat eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). However, their impact on the overall population of uncontrolled CRSwNP remains unclear. To evaluate safety and efficacy GR1802, a novel anti-IL-4Rα monoclonal antibody, in patients. Seventy participants were randomized (1:1) to receive either GR1802 (300 mg an initial doubled dose) or placebo every 2 weeks. Primary endpoints changes from...
Chromobox homologue 7 (CBX7) is a member of the polycomb group family that plays pivotal role in regulating cellular processes human cancers. This study aims to explore function and underlying molecular mechanisms CBX7 lung adenocarcinoma (LUAD) squamous cell carcinoma (LUSC). The expression LUAD LUSC tissues was analyzed by UALCAN GEPIA based on TCGA database. Cell viability apoptosis were measured CCK-8 flow cytometry assays, respectively. migration invasion detected transwell assay....
<title>Abstract</title> Objective:This study aims to retrospectively evaluate the effectiveness of single-segment thoracic sympathotomy in treating palmar hyperhidrosis. Methods:We conducted a retrospective at our center from January 2018 2022. A total 226 patients with hyperhidrosis, who underwent endoscopic sympathectomy, were divided into R3, R4, and asymmetric segment groups (R3 / R4 group). We analyzed effectiveness, side effects, patient satisfaction three treatments through telephone...
Background. Jejunostomy is the main form of enteral nutritional support after McKeown-type esophagectomy. However, this requires jejunum to be secured abdominal wall, which can lead catheter-related complications. Here, we present a new type jejunostomy, ultra-proximal does not require fixation wall. Methods. Patients who underwent esophagectomy between January 2021 and March 2022 were included in study. Postoperative outcomes patients jejunostomy are also presented. Results. Forty-three...