A5002406317- thermodynamics and calorimetric analyses
- Microfluidic and Capillary Electrophoresis Applications
- Electrowetting and Microfluidic Technologies
- Biosensors and Analytical Detection
- Innovative Microfluidic and Catalytic Techniques Innovation
- Physiological and biochemical adaptations
- Microfluidic and Bio-sensing Technologies
- SARS-CoV-2 detection and testing
- Acoustic Wave Resonator Technologies
- Molecular Biology Techniques and Applications
- Thermal properties of materials
- Mechanical and Optical Resonators
- nanoparticles nucleation surface interactions
- Advanced biosensing and bioanalysis techniques
- Nanomaterials and Printing Technologies
- Cell Image Analysis Techniques
- Fluid Dynamics and Heat Transfer
- Viral Infectious Diseases and Gene Expression in Insects
- Infrared Thermography in Medicine
- Pharmacological Effects and Assays
- Advanced Thermoelectric Materials and Devices
- Thermal Radiation and Cooling Technologies
- Micro and Nano Robotics
- COVID-19 epidemiological studies
- RNA and protein synthesis mechanisms
Northwestern Polytechnical University
2018-2025
Hong Kong University of Science and Technology
2020
University of Hong Kong
2020
ThermoGenesis (United States)
2007
Abstract Nanoparticles have become a significant area of research, offering properties that bridge the gap between bulk materials and atomic structures. Silver nanoparticles (AgNPs), specifically, shown promise due to their plasmonic properties. Despite extensive studies, capturing photon-to-heat conversion efficiency individual has been challenging. Here, we present an approach determine these using ultra-sensitive bolometer with power resolution ≈26 pW. Our investigations reveal single...
We developed an image-to-answer algorithm available for chip-based dPCR systems with single fluorescence image capture and known image-related error removal. It automatically corrects the chip structure damage non-uniformity of light intensity.
Calorimetry is crucial in biology, chemistry, physics, and pharmaceutical research, enabling the detection of heat changes at nanowatt picowatt levels. However, traditional calorimetry systems are often limited by high costs complex fabrication processes. Here, we reduce cost complexity microcalorimeters utilizing widely available flexible printed circuit manufacturing This device achieves temperature power resolutions ≈ 6 μK 654 pW vacuum. Its feasibility validated across a wide range...
Accurately detecting subtle thermodynamics during crystallization and associated water evaporation processes, especially around seed formation, has been challenging. Here, we report a method to investigate the complex energy changes these simultaneous endothermic exothermic events. We employ an open-space microcalorimeter, coupled with optical observation using microscope equipped camera for real-time monitoring. This reveals crystal formation by observing simultaneously visualizing sample....
A dual-channel flow-through microcalorimeter device is presented along with a non-contact precision method of temperature calibration. microfluidic channel volume 550 pL in spiral layout was fabricated from low-stress nitride suspended over cavity silicon substrate. The thin-film heater and resistive detector (RTD) on the were defined by patterned Ti layer. exhibited rapid thermal response following characteristics: time constant 10.5 ms, heat conductance 152 μ W · K <sup...
Here, we introduce a microchip for differential measurements of aqueous samples in twin calorimetric arms with sub-nL enclosed space. Each arm features fluidic microchannel located close proximity to thin-film resistance thermometer and heater patterned on low-stress SiN membrane held over Si cavity suspension beams. The chip exhibits rapid response thermal time constant less than 10 ms atmosphere residual conductance below <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML"...
The first DSC chip that features thin-film enclosures, very low-addenda heat capacity, low residual conduction, and rapid response for analyzing liquids.
Microfluidic devices typically require complex shapes such as funnels, spirals, splitters, channels with different widths, or customized objects of arbitrary complexity a smooth transition between these elements. Device layouts are generally designed by software developed for the design integrated circuits general computer-aided drawing tools. Both methods have their limitations, making tasks time consuming. Here, script-based, time-effective method to generate layout various microfluidic...
During infectious diseases outbreaks, the centers for disease control need to monitor particular areas. Considerable effort has been invested into development of portable, user-friendly and cost-effective systems point-of-care (POC) diagnostics. Connecting these via a mobile network would create an 'internet things' (IoT) healthcare, essential tool helping tackle outbreaks. However, at present IoT based on functional POC instrument is not available. Here we show fast, user-friendly,...
Microfluidics systems can be fabricated in various ways using original silicon glass systems, with easy Si processing and surface modifications for subsequent applications such as cell seeding their study. Fluorescent imaging of cells became a standard technique the investigation behavior. Unfortunately, high sensitivity fluorescent imaging, e.g., total internal reflection fluorescence (TIRF) microscopy, is problematic these microfluidic because uneven surfaces channels' bottoms affect light...
Abstract Optofluidic devices combining optics and microfluidics have recently attracted attention for biomolecular analysis due to their high detection sensitivity. Here, we show a silicon chip with tubular microchannels buried inside the substrate featuring temperature gradient (∇ T ) along microchannel. We set up an optical fluorescence system consisting of power-modulated laser light source 470 nm coupled microchannel serving as guide via fiber. Fluorescence was detected on other side...