A5000160179- Bone Tissue Engineering Materials
- Veterinary Medicine and Surgery
- Veterinary Orthopedics and Neurology
- Orthopaedic implants and arthroplasty
- Urological Disorders and Treatments
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Veterinary Equine Medical Research
- Pediatric Urology and Nephrology Studies
- Knee injuries and reconstruction techniques
- Periodontal Regeneration and Treatments
- Colorectal Cancer Surgical Treatments
- Elbow and Forearm Trauma Treatment
- Clinical Nutrition and Gastroenterology
- Intestinal Malrotation and Obstruction Disorders
- Tissue Engineering and Regenerative Medicine
- Intestinal and Peritoneal Adhesions
- Tendon Structure and Treatment
- Polymer Surface Interaction Studies
- Osteoarthritis Treatment and Mechanisms
- Enhanced Recovery After Surgery
- Minimally Invasive Surgical Techniques
- Musculoskeletal pain and rehabilitation
- Sports injuries and prevention
- Orthopedic Infections and Treatments
Inserm
2020-2023
Centre National de la Recherche Scientifique
2016-2023
École Nationale Vétérinaire d'Alfort
2013-2023
Université Paris Cité
2014-2023
Sorbonne Paris Cité
2016-2023
Agence Nationale des Fréquences
2018
Délégation Paris 7
2016-2018
Paris-Est Sup
2018
Laboratoire de Biologie, Bioingéniérie et Bioimagerie ostéoarticulaire
2014-2017
Unité de Recherche en Biomatériaux Innovant et Interfaces
2014
The reconstruction of critical-size bone defects in long bones remains a challenge for clinicians. A new osteoinductive medical device is developed here repair by combining 3D-printed architectured cylindrical scaffold made clinical-grade polylactic acid (PLA) with polyelectrolyte film coating delivering the osteogenic morphogenetic protein 2 (BMP-2). This film-coated used to sheep metatarsal 25-mm defect. In vitro and vivo biocompatibility PLA material proved according ISO standards....
ABSTRACT Tissue‐engineered constructs (TECs) combining resorbable calcium‐based scaffolds and mesenchymal stem cells (MSCs) have the capability to regenerate large bone defects. Inconsistent results have, however, been observed, with a lack of osteoinductivity as possible cause failure. This study aimed evaluate impact addition low‐dose morphogenetic protein‐2 (BMP‐2) MSC‐coral‐TECs on healing clinically relevant segmental defects in sheep. Coral granules were either seeded autologous MSCs...
Ureteral obstruction secondary to ureterolithiasis in cats is a challenging situation. stenting has recently been introduced prevent complications that often occurred after ureterotomy or other invasive surgeries. The purpose of this study describe the technique and perioperative difficulties, as well long-term outcome with ureteral 12 ureteroliths. Fifteen 2.5 Fr soft double pigtail multi-fenestrated stents were placed an anterograde fashion under open surgical approaches fluoroscopic...
Our objectives were: 1) to review the complications associated with stabilization of appendicular fractures in cats and small dogs using locking compression plates (LCP), 2) identify factors that could influence fixation construct stability.Retrospective clinical study.Medical radiographic records treated LCP were reviewed. Only cases adequate follow-up document union for which appeared before included. Complications classified as implant-related or other complications. Cases compared...
To compare the therapeutic potential of tissue-engineered constructs (TECs) combining mesenchymal stem cells (MSCs) and coral granules from either Acropora or Porites to repair large bone defects.Bone marrow-derived, autologous MSCs were seeded on in a perfusion bioreactor. Acropora-TECs (n = 7), Porites-TECs 6) autografts 2) then implanted into 25 mm long metatarsal diaphyseal defects sheep. Bimonthly radiographic follow-up was completed until killing four months post-operatively. Explants...
Objectives This article aimed to describe olecranon fracture in dogs and cats their stabilization with tension band wiring or plate osteosynthesis, evaluate complications associated each technique. Methods Medical records of that had been surgically treated for fractures either osteosynthesis were retrospectively reviewed. The surgical technique, long-term outcomes assessed. Results Forty-one included. Fractures articular, comminuted open 90, 31 27% cases, respectively. Tension performed 22...
Abstract Objective To report outcomes after the correction of ectopic ureter (EU) by open surgery or cystoscopic‐guided laser ablation (CLA) in female dogs. Study design Retrospective study from 2011 to 2018. Animals Twenty‐five Methods Data collected included signalment, clinicopathologic data, procedural complications, and short‐term long‐term outcomes. Complications were graded as minor major if a surgical revision was required. Continence status scored subjectively (1 = completely...
The use of tissue-engineered bone constructs is an appealing strategy to overcome drawbacks autografts for the treatment massive defects.As a model organism, mouse has already been widely used in bone-related research.Large diaphyseal defect models mice, however, are sparse and often fixation which fills marrow cavity does not provide optimal mechanical stability.The objectives current study were develop critical-size, segmental, femoral nude mice.A 3.5-mm mid-diaphyseal ostectomy...
A strategy for improving the efficacy of stem cell-based bone tissue engineering (TE) constructs is to combine morphogenetic protein-2 (BMP-2) with multipotent stromal cells (MSC). Previous studies on potential cooperative effect BMP-2 human (hMSCs) formation in vivo have, however, shown contradictory results likely due various and/or inappropriate doses. Our provided evidence that addition at low dose only was beneficial improve osteogenic hMSCs-containing TE constructs, whereas delivered...
Case history Dogs (n = 6) suffering from elbow-associated lameness for a median of 3.5 (min 2, max 12) months duration requiring arthroscopic exploration according to imaging results were prospectively included in this study.Clinical findings that met the inclusion criteria various breeds with body weight 18 13.2, 34.5) kg and age at presentation 11 6, 96) months. Results modalities (radiographs and/or computed tomography (CT)) consistent developmental elbow disease all dogs.Arthroscopic...
The use of tissue-engineered bone constructs is an appealing strategy to overcome drawbacks autografts for the treatment massive defects. As a model organism, mouse has already been widely used in bone-related research. Large diaphyseal defect models mice, however, are sparse and often fixation which fills marrow cavity does not provide optimal mechanical stability. objectives current study were develop critical-size, segmental, femoral nude mice. A 3.5-mm mid-diaphyseal ostectomy...
A 2‐year‐old spayed female Maine Coon presented with urinary incontinence and recurrent tract infection since 2 months of age. Clinical examination was unremarkable. Ultrasonography, CT cystourethroscopy revealed urogenital abnormalities consistent genitourinary dysplasia. Urethral pressure profilometry suggested urethral sphincter mechanism incompetence. Surgical placement an artificial occluder performed. Mild decrease observed 6 weeks postoperatively. Inflation the under subsequently...
CASE DESCRIPTION 7 privately owned female African lions (Panthera leo) that had been bred for public exhibition and were housed in outdoor pens evaluated prior to undergoing elective ovariectomy. CLINICAL FINDINGS All animals healthy. Median age was 15 months (range, 9 34 months), median body weight 71 kg (156 lb; range, 48 145 [106 319 lb]). TREATMENT AND OUTCOME Surgical sterilization by means of single-incision laparoscopic ovariectomy elected. A 2- 3-cm-long skin incision made just...
Various biomaterials/technologies have been tested for treatment of intervertebral disc (IVD) degeneration (IDD). Only few non-surgical options exist.Assessment efficacy and safety the hyaluronic acid derivative hydrogel HYADD®4-G in IDD using a well-established rabbit annular puncture model.Rabbits were punctured at two IVDs to induce IDD. Thirty days after, injected with or saline. IVD hydration, height, appearance tissue organization assessed by radiographs, MRI histopathology. Safety...
Abstract CASE DESCRIPTION A 3-month-old sexually intact female chinchilla ( Chinchilla lanigera ) was examined for sudden onset of non–weight-bearing lameness the right hind limb. CLINICAL FINDINGS On physical examination, pes swollen. An open wound on medial aspect metatarsal region exposed second bone, and displaced laterally. Radiographs revealed oblique fractures 4 bones. TREATMENT AND OUTCOME Surgical treatment elected, enrofloxacin administered prior to surgery. The protruding fragment...
A 7-year-old, 34-kg, neutered male Labrador retriever was presented with a 1-year history of intermittent sneezing occasional left-sided epistaxis. CT revealed mass in the left nasal cavity. Histopathological analysis rhinoscopy-guided tissue biopsies consistent chronic necrotic and ulcerative rhinitis. Surgical debridement by ventral rhinotomy subsequently performed histopathological diagnosis leiomyoma. Complete resolution discharge reduced frequency were observed after surgery. Fourteen...
This study evaluated success rates of surgical treatment head and neck abscesses draining tracts for suspected migrating vegetal foreign body oropharyngeal penetrating injuries, compared the outcomes according to whether a was identified in preoperative computed tomography (CT) examination.This retrospective involved 39 dogs that underwent CT subsequent exploration and/or neck, single institution between 2010 2021. Recorded data included signalment, history, physical examination, findings....
Summary Objectives: This case report describes for the first time a bone haemophilic pseudotumour in dog. Case description: A seven-month-old German Shepherd male dog was presented with complaint of forelimb weight-bearing lameness major swelling that expanded dramatically after fine needle aspiration. Radiographs showed large, well-defined ulnar diaphyseal cystic-like osteolytic lesion. Based on prolonged activated partial thromboplastin (aPTT) and low factor VIII activity, haemophilia...