A5080676689- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Folate and B Vitamins Research
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Pituitary Gland Disorders and Treatments
- Cancer-related molecular mechanisms research
- Sexual Differentiation and Disorders
- Advanced biosensing and bioanalysis techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pharmacovigilance and Adverse Drug Reactions
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Adrenal and Paraganglionic Tumors
- 14-3-3 protein interactions
- Medical Malpractice and Liability Issues
- Travel-related health issues
- Microbial Natural Products and Biosynthesis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Acute Lymphoblastic Leukemia research
- Kruppel-like factors research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Monoclonal and Polyclonal Antibodies Research
Beykent University
2022-2023
Ege University
2011-2018
Selçuk Üniversitesi Tıp Fakültesi Hastanesi
2015
Ege Üniversitesi Tıp Fakültesi Hastanesi
2014
We have investigated defective steps in apoptosis that might account for the development of resistance. For this purpose, A549 and Calu1 NSCLC (non-small-cell lung cancer) cell lines were treated with cisplatin to obtain resistant sub-lines. Gene expression profiles phosphorylation status BAD (Bcl-2/Bcl-XL-antagonist, causing death) protein determined each line. Cell death cytochrome c release analysed after treating their appropriate doses. BAD, Bid, caspases 4 6 clearly decreased lines,...
The aim of this study was to determine the frequencies Y chromosome microdeletions in infertile azoospermic and oligozoospermic Turkish men healthy control subjects.Sixty-four 51 patients patients, 70 who had a child without aid assisted reproductive technologies were included study. DNA extracted from peripheral blood samples collected patients. Following multiplex PCR performed with 15 different primer sequences, AZFa, AZFb, AZFc AZFd region determined by agarose gel electrophoresis.Y...
Folate metabolism is fundamental to several biological functions and required for cell replication, division, survival. The mammalian folic acid cycle highly complex the enzymes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), (MTRR), have crucial roles in this metabolic pathway. common polymorphisms of MTHFR (C677T A1298C), MTRR (A66G), MTR (A2756G) enzymes are well documented as folate deficiency-related disorders, but their not been examined acromegalic patients....
Abstract The efficacies of chemotherapeutic agents are often limited by side effects and acquired drug resistance. We have investigated whether the differential expression pattern 14‐3‐3σ affects cisplatin response in non‐small cell lung cancer lines. Two pairs parental/cisplatin resistant lines (A549/CRA549 Calu1/CR‐Calu1) clinical biopsy samples were analysed for expression. Cell viability was assessed WST assay; suppressed siRNA transfection. mRNA increased CR‐A549 CR‐Calu1 compared with...
We aimed to determine the genotype distribution, allele frequency, and prognostic impact of IDH1/2, TET2, ASXL1 single nucleotide polymorphisms (SNPs) in myeloproliferative neoplasms (MPNs).TET2 (rs763480), (rs2208131), IDH1 (rs11554137) variant homozygous frequencies were found at rates 1.5%, 9.2%, 2.3%, respectively.No IDH2 SNP was identified.IDH1 TET2 5% essential thrombocythemia (ET) 1.7% ET primary myelofibrosis (PMF), respectively.ASXL1 8.3%-10% MPN subgroups.The mutant T G had highest...
Amaç: t(4;11), MLL-AF4 translokasyonu sonucu oluşan, 4q21 kromozomal bandına yerleşim gösteren AF4 geninin 11q23 MLL genine füzyonu gelişen bir anomalidir. Bu çalışmada, retrospektif olarak 2009-2013 yılları arasındaki akut lenfoblastik lösemi (ALL) hastalarındaki t(4;11) translokasyonunun analiz sonuçlarının incelenmesi amaçlandı. Gereç ve Yöntem: Ege Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı'na arasında ön tanısıyla 176 çocuk (70 kız, 106 erkek) 144 yetişkin (60 kadın, 84...
Amaç: Akut promyelösitik lösemi (APL), akut myeloid löseminin (AML) iyi tanımlanmış alt tipidir ve spesifik olarak t(15;17)(q22;q12) translokasyonu ile karakterizedir. t(15;17), 15. kromozom üzerinde bulunan (PML) 17. kromozomda lokalize retinoik asit reseptör alfa (RARA) genlerinin füzyonu sonucu oluşur. Translokasyon varlığı, konvansiyonel sitogenetik, floresan in situ hibridizasyon analizi (FISH) sıklıkla gerçek zamanlı kantitatif revers transkriptaz polimeraz zincir reaksiyonu (qRT-PCR)...
Amaç: Bu çalışmada, Ege Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı'na 2009-2013 yılları arasında akut myeloid lösemi (AML) ön tanısı ile başvuran 402 olgunun (322 yetişkin, 80 çocuk) kan veya kemik iliği örneklerinin inv16 kantitasyon analizlerinin RT-PCR yöntemi değerlendirilmesi amaçlandı. Gereç ve Yöntem: Hastalardan alınan örneklerinden total RNA/mRNA izolasyonunu takiben cDNA'ları elde edilerek revers-transkriptaz-polimeraz zincir reaksiyonu (RT-PCR) yöntemiyle kantitasyonu...