A5061036019- Natural product bioactivities and synthesis
- Phytochemical Studies and Bioactivities
- Biological Activity of Diterpenoids and Biflavonoids
- Medicinal plant effects and applications
- Phytochemistry and Biological Activities
- Cancer-related Molecular Pathways
- Medicinal Plant Pharmacodynamics Research
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Diverse Scientific Research in Ukraine
- Mesenchymal stem cell research
- Protease and Inhibitor Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Hops Chemistry and Applications
- Pluripotent Stem Cells Research
- Ginger and Zingiberaceae research
- Endoplasmic Reticulum Stress and Disease
- Adenosine and Purinergic Signaling
- Traditional Chinese Medicine Analysis
- Protein Degradation and Inhibitors
- interferon and immune responses
- Galectins and Cancer Biology
- Circular RNAs in diseases
Gannan Medical University
2011-2023
Hunan University of Traditional Chinese Medicine
2014
Background/Aims: P-glycoprotein (P-gp, i.e., MDR1) is associated with the phenotype of multidrug resistance (MDR) and causes chemotherapy failure in management cancers. Searching for effective MDR modulators combining them anticancer drugs a promising strategy against MDR. Asiatic acid (AA), natural triterpene isolated from plant Centella asiatica, may have an antitumor activity. The present study assessed reversing effect AA on possible molecular mechanisms action MDR1-overexpressing...
Background: Tumor necrosis factor (TNF)-α can upregulate the expression of plasminogen activator inhibitor (PAI)-1, an fibrinolysis. Adiponectin (Adp) antagonizes TNF-α by negatively regulating its in various tissues. In present study, ability Adp to suppress TNF-α-induced PAI-1 upregulation and underlying mechanisms were evaluated. Methods: Human umbilical vein endothelial cells (HUVECs) treated with presence or absence Adp, mRNA antigen expression, activated signaling pathways, molecular...
Drug resistance becomes a challenge in the therapeutic management of non-small cell lung cancer (NSCLC). According to our former research, asiatic acid (AA) re-sensitized A549/DDP cells cisplatin (DDP) through decreasing multidrug protein 1 (MDR1) expression level. However, relevant underlying mechanisms are still unclear. Long non-coding RNA (lncRNA) MALAT1 shows close association with chemo-resistance. As reported this AA increased apoptosis rate, down regulated MALAT1, p300, β-catenin,...
Yuzhu (Polygonati Odorati Rhizoma), Kangdingyuzhu Prattii and zhugenqiyuzhu (Disporopsis Fuscopictae Rhizoma) are of the same family, but different genera. They have all often used in Chinese Materia Medica (CMM) as Polygonati Rhizoma China market. Three species CMM confused. For better application, we need to identify these plants accurately. This study use pharmacognosy technique GC-MS analysis, three were authenticated. In macroscopic characteristics, fruit is blue-black, while other two...
Colorectal cancer (CRC) is the second most common cause of cancer-related mortality and lies third in terms morbidity due to limited number effective druggable targets. Since stem cells (CSCs) are considered be one roots tumorigenesis, outgrowth metastasis, targeting CSCs may a promising strategy reverse malignant phenotypes CRC. Cyclin-dependent kinase 12 (CDK12) has been reported involved self-renewal various cancers, rendering it an attractive potential target against consequently limit...
Objective: To investigate inhibitory effect of TUA (2β, 3β, 23-trihydroxy-urs-12-en-28-oic acid) isolated from Actinidia chinensis Radix on the lung cancer xenografts in nude mice and explore its preliminary mechanism. Methods: NCI-H460 cells were implanted into transplantation tumor block more than 2 generations was inoculated to right armpits BALB/c with dissecting needle establish a xenograft model. When transplanted volume about 50 mm3, randomly divided 6 groups: (1) model group; (2) 10...