Current sprayable hydrogel masks lack the stepwise protection, cleansing, and nourishment of extensive wounds, leading to delayed healing with scarring. Here, we develop a biomimetic double wound mask (BDM) rapid autophasing hierarchical programming for scarless healing. The BDMs comprise hydrophobic poly (lactide-

(1) Background: Gamma cameras have wide applications in industry, including nuclear power plant monitoring, emergency response, and homeland security. The desirable properties of a gamma camera include small weight, good resolution, large field view (FOV), imageable source energy range. Compton can 4π FOV but limited sensitivity at low energy. Coded-aperture are operatable photon range typically increased weight due to the thick heavy metal collimators shielding. In our lab, we previously...

Monolithic PET detector design is promising for low cost, high packing fraction, intrinsic depth-of-interaction (DOI) capability as well potentially better energy and timing resolution compared to the conventional segmented crystal-based design. In this work, we developed a monolithic with 3D positioning readout channel number compression. The contains LYSO crystal (size: 25 mm × 14 mm) coupled 6 SiPM array (SensL FC30035). Two algorithms including statistical-based (SBP) artificial neural...

Proton therapy is attracting increasing attention nowadays owing to its accurate dose delivery the target tumor. However, this advanced treatment modality subject proton beam range uncertainty, which could lead overdose in healthy tissues. In past decades, prompt gamma imaging (PGI) has gained interest and been proved promising for realtime monitoring. The detection of 2-8 MeV high energy gamma, however, poses a serious challenge PGI system design, especially, detector design. article, we...

We have developed a PET detector module based on sub-millimeter lutetium oxyorthosilicate (LSO) crystal block and prototype Silicon Photomultiplier (SiPM) arrays with additional fast timing output. The LSO array consists of 20×20 crystals which each pixel is 0.78 × 0.78×3 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> the pitch 0.8 due to reflector between pixels. FM SiPM FB are arranged 4×4 4×4mm...

A novel series of sulfobetaine surfactants, 3-((4-(alkoxy)-3,5-dimethylbenzyl) dimethylammonio)-2-hydroxy-propane-1-sulfonate (CnOBSb, n = 12, 14, and 16), were synthesized for the first time. The chemical structures products characterized by high-resolution mass spectra, 1H NMR, 13C NMR spectrometry. physicochemical properties CnOBSb studied thermogravimetric analysis, equilibrium surface tension measurement, steady-state fluorescence, dynamic light scattering (DLS), cryogenic transmission...

Modern positron emission tomography (PET) detectors are made from pixelated scintillation crystal arrays and readout by Anger logic. The interaction position of the gamma-ray should be assigned to a using map or look-up table. Crystal identification is critical procedure for PET systems. In this paper, we propose novel method dual-layer-offset LYSO based animal system via Lu-176 background radiation mean shift algorithm. Single photon event data acquired in list-mode 3 h generate single...

NaI(Tl) spectrometry is widely used in many areas for gamma-ray detection. It can be both activity measurement and isotope identification. However, the light generation of photomultiplier tube (PMT) sensitive to temperature changes, which lead spectrum shift. Several calibration methods have been proposed, but they are complicated. In this article, we developed an indoor monitoring studied influences from 5 °C 35 using a <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Silicon Photomultiplier (SiPM) has been demonstrated to be a high performance PET sensor as alternative conventional photomutiplier tubes. The aim of this work is develop detector module with compact SiPM device which consists 3×3 arrays (4×4 pixels each array,3.17×3.17 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> pixel). A design readout electronics proposed based on discretized position-sensitive circuits (DPC) and time ASIC....

Silicon photomultipliers (SiPM) are rapidly adapted in simultaneous time of flight (TOF) PET and MRI imaging system recent years due to its fast timing response immunity magnetic field. The aim this work is develop multi-channel SiPM readout electronics for clinical TOF detector. detector module assembled by directly coupling a 12×12 LYSO crystal block an 8×8 Sensl FB30035 array. We developing two approaches compact handle the large number output channels. One low noise high bandwidth,...

Proton therapy is currently one of the most advanced radiotherapy technologies. However, due to proton range uncertainty during dose delivery, monitoring vital importance for therapy. In recent years, there has been increased interest utilizing prompt gamma imaging (PGI) online its high yield, real-time emission property and immunity biological wash-out effect. 2 ~ 8 MeV energy makes detector design PGI system challenging saturation effect SiPM, which a kind commonly used photodetector in...

Silicon Photomultiplier (SiPM) is a promising sensor for MR-compatible PET systems.In this paper, we developed compact 2-layer DOI-PET detector.The top layer 15Ã15 LYSO array, and the crystal size 2x2x7mm 3 .The bottom 16Ã16 array with same crystals.There half-crystal offset between two layers in both transverse directions.The detector coupled to an 8Ã8 SiPM (MicroFB-30035-SMT, Sensl).Sixty-four channels of SiPMs are read out by ASIC chip in-chip multiplexing resistor networks form position...

Design of the light sharing mechanisms has a significant influence on performance PET block detector. Monte Carlo simulation plays an important role in detector design and optimization. In this work, GATE is used to simulate transportation processes gamma rays scintillated optical photons PMT-based 9×9 L YSO self-developed animal system. The aim work optimize parameters design. Scintillation are generated transported crystal array finally detected by 4 PMTs. Based 2D Anger logic, position...

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Radioactive sources are widely used in industrial and medical applications. In home-land security, it is important to monitor radioactive source public areas such as airport prevent hazard. Traditional radiation detection devices Geiger counter cannot provide position information. Exist imaging including Gamma cameras with mechanical collimators, or Compton can only determine directional information of the over 4π angular space, which not enough for accurate positioning crowded high...

A novel silicon photomultipliers (SiPM) has been developed with both a standard and fast output, aiming at providing good energy timing performance simultaneously for time of flight (TOF) PET application. Optimal readout method this SiPM is investigated in study. The output can be taken from either anode terminal or cathode different dual mode impact on resolution output. Three methods were evaluated we found the optimized way was to side small capacitance parallel. This preserve using...