A5101575060- Parallel Computing and Optimization Techniques
- Distributed and Parallel Computing Systems
- Advanced Data Storage Technologies
- Cloud Computing and Resource Management
- Embedded Systems Design Techniques
- Green IT and Sustainability
- Caching and Content Delivery
- Scientific Computing and Data Management
- Gastrointestinal motility and disorders
- Business Process Modeling and Analysis
- Service-Oriented Architecture and Web Services
- Software System Performance and Reliability
- Advanced Software Engineering Methodologies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Heart Disease Studies
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Advanced Radiotherapy Techniques
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Congenital gastrointestinal and neural anomalies
- Inhalation and Respiratory Drug Delivery
- Low-power high-performance VLSI design
- Acute Ischemic Stroke Management
- Microscopic Colitis
Kaiser Permanente
2024
Royal Orthopaedic Hospital
2021
Curtin University
2020
St John of God Subiaco Hospital
2020
Imperial College London
2020
Harefield Hospital
2020
Sandia National Laboratories
1991-2019
East Carolina University
1986-2019
Sandia National Laboratories California
2005-2016
Novartis (Canada)
2006-2012
It is conventionally considered that because of their fiber orientations, the external intercostal muscles elevate ribs, whereas internal interosseous intercostals lower ribs. The mechanical action muscles, however, has never been studied directly, and electromyographic observations supporting this conventional thinking must be interpreted with caution. In present studies, have separately stimulated in different interspaces at, above, below end-expiratory rib cage volume anesthetized dogs....
To achieve exascale computing, fundamental hardware architectures must change. This will significantly impact scientific applications that run on current high performance computing (HPC) systems, many of which codify years domain knowledge and refinements for contemporary computer systems. adapt to architectures, developers be able reason about new determine what programming models algorithms provide the best blend energy efficiency in future. An abstract machine model is designed expose...
We measured tracheal flow from sounds to estimate tidal volume, minute ventilation (V˙i), respiratory frequency, mean inspiratory (Vt/Ti), and duty cycle (Ti/Ttot). In 11 normal subjects, 3 patients with unstable airway obstruction, stable asthmatic patients, we twice: first derive flow-sound relationships second obtain flow-volume the sound signal. The relationship was compared pneumotach-derived volume. When subjects were seated, facing forward neck rotation, flexion, standing, within 15%...
The pressure swings under the costal (Pcos) and crural diaphragms (Pcru) between intestinal loops (Pint) were compared with in gastric (Pga) 13 supine anesthetized dogs. Pcos, Pcru, Pint measured air-filled latex balloons eight dogs saline-filled catheters five. Pga was an balloon all During quiet breathing differences often present, directions of which variable from animal to animal. mechanical ventilation, pressures increased, but both Pcos Pcru increased more than Pga, whereas only a...
This study was designed to assess the influence of voluntary patterns respiratory muscle contractions on distribution inspired gas at low flows (0.4 liter per sec). Three types inspiration were studied in 9 normal subjects upright, supine, and lateral decubitus posture: (1) natural, (2) intercostal, during which rib cage expansion accentuated by preferential use intercostal accessory muscles, (3)abdominal, abdominal motion enhanced. The assessed monitoring transdiaphragmatic pressure...
Recognition of the importance power in field High Performance Computing, whether it be as an obstacle, expense or design consideration, has never been greater and more pervasive. In response to this challenge, we exploit unique measurement capabilities Cray XT architecture gain understanding requirements important DOE/NNSA production scientific computing applications executing at large scale (thousands nodes). The effect both CPU frequency network bandwidth scaling on usage is characterized...
INTRODUCTION: No recent Canadian studies with physician‐ and spirometry‐confirmed diagnosis of chronic obstructive pulmonary disease (COPD) that assessed the burden COPD have been published. OBJECTIVE: To assess costs associated maintenance therapy treatment for acute exacerbations (AECOPD) over a one‐year period. METHODS: Respirologists, internists family practitioners from across Canada enrolled patients an established moderate to severe (Global initiative chonic Obstructive Lung Disease...
The external and internal interosseous intercostal muscles were separately stimulated at end-expiratory lung volume in anesthetized dogs. These all found to elevate the ribs into which they insert. By attaching weights ribs, it was determined that nonlinear compliance of responsible for this phenomenon.
Power has recently been recognized as one of the major obstacles in fielding a Peta-FLOPs class system. To reach Exa-FLOPs, challenge will certainly be compounded. In this paper we discuss number High Performance Computing power related topics. We first describe our implementation scalable measurement framework that enabled us to examine real use (current draw). [Using framework, samples were obtained at per-node (socket) granularity, frequencies up 100 per second.] Additionally, how applied...
To assess the mechanical arrangement of costal and crural parts diaphragm, we studied changes in diaphragmatic length with piezoelectric crystals 17 supine anesthetized dogs. During control resting inspiration, part usually shortened more earlier than part. After phrenicotomy, always lengthened during whereas or lengthened. These interanimal differences disappeared after opening abdomen; then inspiration. stimulation one part, relaxed nonstimulated However, when compared relationship between...
Exercise stress testing (EST) is a screening test for coronary artery disease. Previous studies from the cardiology literature show an overall sensitivity of 67% and specificity 72% with variable predictive values depending on pretest probability. The purpose current study was to evaluate value EST in family medicine population eastern North Carolina.This retrospective case series 339 ESTs performed center July 2001 April 2005. results were classified as positive, negative, or equivocal....
The Red Storm architecture, which was conceived by Sandia National Laboratories and implemented Cray, Inc., has become the basis for most successful line of commercial supercomputers in history. success architecture is due largely to ability effectively efficiently solve a wide range science engineering problems. Cray XT series machines that embody have allowed unprecedented scaling performance parallel applications spanning many areas scientific computing. This paper describes fundamental...
Seven beagles were exposed via a tracheostomy to smoke from 10 cigarettes/day, 5 days/wk for months; 2 other dogs 6 months only. Four served as sham-exposed control animals. Mucus was collected times/wk prior and during the exposure period by resting cytology brush on lower trachea min. At least once often 3 times exposure, transpulmonary pressure flow monitored under anesthesia determine resistance RL. Two airway responses methacholine determined: infusion response delta Ri, increment in RL...
Postobstructive pulmonary vasculopathy, produced by chronic ligation of one artery, markedly increases bronchial blood flow. Previously, using arterial and venous occlusion, we determined that collaterals enter the circuit at distal end segment. In this study, tested hypothesis pressure in (Pbr) closely approximates downstream segment (Pao). We pump perfused [111 +/- 10 (SE) ml/min] left lower lobes seven open-chest live dogs 3–15 mo after main artery. Bronchial flow was 122 16 ml/min....