A5101702661- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Prion Diseases and Protein Misfolding
- Tryptophan and brain disorders
- Neurological diseases and metabolism
- Adipose Tissue and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- Cholinesterase and Neurodegenerative Diseases
- Diet and metabolism studies
- Pharmacological Effects and Assays
- Receptor Mechanisms and Signaling
- SARS-CoV-2 and COVID-19 Research
- Nuclear Receptors and Signaling
- Medicinal Plants and Neuroprotection
- Gut microbiota and health
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Human-Animal Interaction Studies
- Trauma and Emergency Care Studies
- Metallurgy and Material Science
- Immune responses and vaccinations
Slovak Academy of Sciences
2015-2024
Institute of Neuroimmunology of the Slovak Academy of Sciences
2015-2024
Czech Academy of Sciences, Institute of Microbiology
2024
AXON Neuroscience (Slovakia)
2014-2024
Czech Academy of Sciences
2011-2024
The AD Centre
2020
Czech Academy of Sciences, Institute of Physiology
2011
Research Triangle Park Foundation
1986-1999
Rush University Medical Center
1993
GlaxoSmithKline (Netherlands)
1988
We have identified structural determinants on tau protein that are essential for pathological tau-tau interaction in Alzheimer's disease (AD). These regulatory domains, revealed by monoclonal antibody DC8E8, represent a novel target tau-directed therapy. In order to validate this target, we developed an active vaccine, AADvac1.A peptide encompassing the epitope DC8E8 was selected development of vaccine targeting mis-disordered interaction. The efficacy tested transgenic rat model human...
Neurofibrillary pathology composed of tau protein is closely correlated with severity and phenotype cognitive impairment in patients Alzheimer's disease non-Alzheimer's tauopathies. Targeting pathological proteins via immunotherapy a promising strategy for disease-modifying treatment disease. Previously, we reported 24-week phase 1 trial on the active vaccine AADvac1 against protein; here, present results further 72 weeks follow-up those patients. We did 1, 72-week, open-label study mild to...
BackgroundTau pathology correlates with and predicts clinical decline in Alzheimer's disease. Approved tau-targeted therapies are not available.MethodsADAMANT, a 24-month randomised, placebo-controlled, parallel-group, double-blinded, multicenter, Phase 2 trial (EudraCT2015-000630-30, NCT02579252) enrolled 196 participants disease; 119 included this post-hoc subgroup analysis. AADvac1, active immunotherapy against pathological tau protein. A machine learning model predicted likely...
The discovery that peroxisome proliferator-activated receptor (PPAR)-gamma was the molecular target of thiazolidinedione class antidiabetic agents suggested a key role for PPAR-gamma in regulation carbohydrate and lipid metabolism. Through use high-throughput biochemical assays, GW1929, novel N-aryl tyrosine activator human PPAR-gamma, identified. Chronic oral administration GW1929 or troglitazone to Zucker diabetic fatty (ZDF) rats resulted dose-dependent decreases daily glucose, free acid,...
Sarcopenia is associated with reduced quality of life and premature mortality. The sex disparities in the processes underlying sarcopenia pathogenesis, which include mitochondrial dysfunction, are ill-understood can be decisive for optimization sarcopenia-related interventions. To improve knowledge regarding differences skeletal muscle aging, gastrocnemius young old female male rats was analyzed a focus on remodeling through proteome profiling mitochondria-enriched fractions. best our...
Abstract Background Numerous epidemiological studies demonstrate that genetic background modifies the onset and progression of Alzheimer's disease related neurodegenerative disorders. The efficacious influence on pathway amyloid beta has been meticulously described in rodent models. Since impact modifiers neuroinflammatory cascade induced by misfolded tau protein is yet to be elucidated, we have addressed issue using transgenic lines expressing same human truncated either spontaneously...
Abstract Background Prognostic studies in the context of Alzheimer's disease (AD) mainly predicted time to dementia. However, it is questionable whether onset dementia most relevant outcome along AD trajectory from perspective patients and their care partners. Therefore, we aimed identify outcomes viewpoint Methods We used a two‐step, mixed‐methods approach. As first step conducted four focus groups Netherlands elicit comprehensive list considered important by ( n = 12) partners 14)...
5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83) is a selective anti-human immunodeficiency virus (HIV) agent. When tested in phytohemagglutinin-stimulated normal human peripheral blood lymphocytes against fresh clinical isolates of HIV type 1 (HIV-1) obtained from patients naive to AZT (3'-azido-3'-deoxythymidine [zidovudine]), 935U83 inhibited growth with an average 50% inhibitory concentration (IC50) 1.8 microM; corresponding IC50s were 0.10 microM for FLT (3'-deoxy-3'-fluorothymidine)...
Background: The Cogstate Brief Battery (CBB) is a computerized cognitive test battery used commonly to identify deficits related Alzheimer’s disease (AD). However, AD and normative samples understand the sensitivity of CBB in clinic have been limited, as outcome measures studied. Objective: This study investigated outcomes, including potential composite scores, impairment mild (MCI) dementia due AD, carefully selected samples. Methods: Samples consisted 4,871 cognitively unimpaired adults...
Neuroendocrine and behavioral stress responses are orchestrated by corticotropin-releasing hormone (CRH) norepinephrine (NE) synthesizing neurons. Recent findings indicate that may promote development of neurofibrillary pathology in Alzheimer's disease. Therefore, we investigated relationships among stress, tau protein phosphorylation, brain NE using wild-type (WT) CRH-knockout (CRH KO) mice. We assessed expression phosphorylated (p-tau) at the PHF-1 epitope concentrations locus coeruleus...
Brain norepinephrine (NE) plays an important role in the modulation of stress response and neuroinflammation. Recent studies indicate that Alzheimer's disease (AD), tau neuropathology begins locus coeruleus (LC) which is main source brain NE. Therefore, we investigated changes NE system also immune status under basal conditions transgenic rats over-expressing human truncated protein. Brainstem catecholaminergic cell groups (LC, A1, A2) forebrain subcortical (nucleus basalis Meynert),...