Hebao Wen

ORCID: 0000-0003-2478-0956
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Research Areas
  • Mesenchymal stem cell research
  • Pluripotent Stem Cells Research
  • Tissue Engineering and Regenerative Medicine
  • Cancer-related molecular mechanisms research
  • Electrospun Nanofibers in Biomedical Applications
  • Neurogenesis and neuroplasticity mechanisms
  • MicroRNA in disease regulation
  • Oral microbiology and periodontitis research
  • Silk-based biomaterials and applications
  • Neuroscience and Neural Engineering
  • Inflammation biomarkers and pathways
  • Motivation and Self-Concept in Sports
  • Gut microbiota and health
  • Cancer-related gene regulation
  • Animal Genetics and Reproduction
  • Muscle Physiology and Disorders
  • Mindfulness and Compassion Interventions
  • Health and Wellbeing Research
  • Osteoarthritis Treatment and Mechanisms
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Pancreatic function and diabetes
  • RNA modifications and cancer
  • Lipid metabolism and disorders

Bengbu Medical College
2023-2025

Weatherford College
2024

Chinese Academy of Agricultural Sciences
2017-2018

Mudanjiang Normal University
2018

Attention is a crucial cognitive ability for sports performance. The current research aimed to investigate whether long-term mindfulness meditation (MM) intervention enhances male athletes' attentional function and alters the activity of brain regions related attention. In this experiment, we recruited 47 professional fencer athletes completed two main trials-an MM trial control trial. trial, participants were provided with 3 sessions/wk (20 min/session) training 20 weeks. instead assigned...

10.1038/s41598-025-97179-w article EN cc-by-nc-nd Scientific Reports 2025-04-15

Stem cells from the apical papilla (SCAPs) show strong odontogenic ability and can form root dentin. However, underlying mechanisms that control differentiation of SCAPs in an inflammatory environment need further exploration. In present study, we explored regulatory role METTL3 originating tooth with periodontitis. derived healthy teeth periodontitis (AP-SCAPs) were successfully isolated cultured. The expressions tumor necrosis factor-a (TNF-a) interleukin-6 (IL-6) higher AP-SCAPs. A...

10.1016/j.yexcr.2025.114576 article EN cc-by Experimental Cell Research 2025-04-23

Neural stem cells (NSCs) are multipotent that can differentiate into many cell types in vitro. In this study, we isolated and established an NSC line from fetal Ovis aries. Based on the results of immunofluorescence staining, NSCs expressed Nestin, Pax6 MAP2. Moreover, a reverse transcription-polymerase chain reaction assay was used to biologically characterize line. were induced neurogenic They MAP2, glial fibrillary acidic protein (GFAP) myelin basic (MBP). successfully cultivated...

10.1080/19768354.2017.1354915 article EN cc-by Animal Cells and Systems 2017-07-04

Cartilage stem/progenitor cells (CSPCs) are a novel stem cell population and function as promising therapeutic candidates for cell‑based cartilage repair. Until now, numerous existing research materials have been obtained from humans, horses, cows other mammals, but rarely sheep. In the present study, CSPCs with potential applications in repairing tissue damage therapy were isolated 45‑day‑old Small‑tailed Han Sheep embryos, examined at cellular molecular level. The expression level of...

10.3892/ijmm.2018.3629 article EN International Journal of Molecular Medicine 2018-04-17

Adipose tissue-derived mesenchymal stem cells (ADSCs) play a crucial role in the field of regenerative medicine and tissue repair for its own unique features. However, up to date, isolation characterizations multidifferentiation potentials goose ADSCs are still uncertain. In this study, we successfully isolated from inguinal groove vitro first time also attempted unravel fundamental differentiation genetic characteristics. The results showed that exhibited typical fibroblast-like morphology...

10.1089/dna.2017.4061 article EN DNA and Cell Biology 2018-08-13

The skin is a natural target of stem cell research because its large size and easy accessibility. Cutaneous mesenchymal cells have shown to be promising source various adult or progenitor populations, which provide an important cell-based investigation. Nowadays, much work has been done on dermal-derived (DMSCs) from humans, mice, sheep, other mammals, but the literature avian species rarely reported. As animal model, goose endemic abounding in dermal tissues global economy. In this study,...

10.3382/ps/pey178 article EN cc-by-nc-nd Poultry Science 2018-05-21

Parkinson's disease (PD) is a neurodegenerative disorder primarily caused by the loss of dopaminergic neurons (DA) in brain. Since DA are non-renewable, conventional therapies only alleviate symptoms without addressing root cause. This study aims to reprogram astrocyte (AS) into for transplantation brain reconstruct damaged neural circuits and treat PD. Astrocytes were isolated from neonatal rat tissues. A lentiviral vector carrying transcription factors nuclear receptor-related factor 1...

10.11817/j.issn.1672-7347.2024.240078 article EN PubMed 2024-01-01

Pulmonary mesenchymal stem cells (PMSCs) are considered important in therapeutic and regenerative responses to lung injury. Despite extensive studies on the human, porcine, sheep, mouse rat, it was found that PMSCs, which can been performed goose, have not well explored. Elucidation of cell differentiation, proliferation, yet described, may promote development injured therapy. In our study, we firstly disclosed biological characteristics spindle-shaped PMSCs from pulmonary tissues goose...

10.1590/1678-4324-2024230139 article EN cc-by Brazilian Archives of Biology and Technology 2024-01-01

Several studies have reported a potential association between the gut microbiota (GM) and scoliosis. However, causal relationship GM scoliosis role of inflammatory factors (IFs) as mediators remain unclear. This study aimed to analyze GM, IFs, We investigated whether IFs act in pathways from Additionally, using reverse Mendelian randomization (MR) analysis, we further impact genetic predisposition on IFs. In this study, searched for publicly available genome-wide aggregate data utilized MR...

10.1097/md.0000000000038561 article EN cc-by-nc Medicine 2024-06-14

This study employed Mendelian randomization (MR) analysis to explore potential causal relationships between 731 immune cell subtypes and periodontitis. Utilizing a 2-sample MR design, our delved into the diverse landscape of interactions with periodontitis-associated factors. Multiple methods, including inverse variance weighting, weighted median, MR-Egger tests, were ensure reliability mitigate pleiotropic effects. The revealed significant effects (FDR < 0.15) cells (B cells, maturation...

10.1097/md.0000000000040918 article EN cc-by-nc Medicine 2024-12-13

HIGHLIGHTS Broiler-derived UMSCs line was successfully isolated for the first time. possessed stemness characteristics, such as hereditary stability, self-renewal ability, and expression of specific markers. multilineage potential could be differentiated into cells three layers.

10.1590/1678-4324-2023220031 article EN cc-by-nc Brazilian Archives of Biology and Technology 2023-01-01

With the ability of self-renewal and multipotenntial differentiation, muscle satellite cells (MSCs) are recognized as a population tissue-specific progenitors which play an important role in growth, repair regeneration muscles. Satellite have been isolated for very long time, but techniques isolation still to be improved. In this study, MSCs were obtained from aborted Tibetan mastiff fetuses (about 60 days) under sterile conditions. Primary sub-cultured passage 25 vitro . The gene C-met,...

10.1166/jbt.2019.2030 article EN Journal of Biomaterials and Tissue Engineering 2019-05-01

This study reports the presence of 119 species from 45 families belonging to 19 orders in Kocaçay Delta, Turkey, within borders Karacabey District Bursa Province, a conducted over course one year (2017).The distribution terms is as follows: Falconiformes, 1 (0.8%); Phoenicopteriformes, Bucerotiformes, Galliformes, Cuculiformes, Caprimulgiformes, Coraciiformes, 2 (1.6%); Gruiformes, Podicipediformes, Suliformes, Pelecaniformes, 3 (2.5%);Strigiformes, (2.5%);Columbiformes, 4...

10.17582/journal.pjz/20211230091225 article EN Pakistan Journal of Zoology 2022-01-01
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