A5102936566- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Prostate Cancer Treatment and Research
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Peroxisome Proliferator-Activated Receptors
- Photodynamic Therapy Research Studies
- Genomics and Chromatin Dynamics
- Cell Adhesion Molecules Research
- Hormonal and reproductive studies
- Adipose Tissue and Metabolism
- Lung Cancer Treatments and Mutations
- Lipid metabolism and biosynthesis
- Carbohydrate Chemistry and Synthesis
- Cardiac Valve Diseases and Treatments
- Protease and Inhibitor Mechanisms
- Metabolism and Genetic Disorders
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Connective tissue disorders research
- Prostate Cancer Diagnosis and Treatment
North Carolina State University
2018-2025
King's College London
2024
University of North Carolina at Chapel Hill
2021
North Central State College
2019
Leidos (United States)
2018
Frederick National Laboratory for Cancer Research
2018
University of Nebraska–Lincoln
2008-2017
Susan Thompson Buffett Foundation
2015
Fred and Pamela Buffett Cancer Center
2015
University of Nebraska Medical Center
2007-2012
Methylation of histones at specific residues plays an important role in transcriptional regulation. Chromatin immunoprecipitation dimethylated lysine 9 on histone H3 across 53 kilobases the chicken beta-globin locus during erythropoiesis shows almost complete anticorrelation between regions elevated methylation and acetylation. Lysine is methylated most over constitutive condensed chromatin developmentally inactive globin genes. In contrast, 4 correlates with These results lead us to propose...
The availability of mice containing an adipocyte lipid-binding protein (ALBP/aP2) gene disruption allowed for a direct examination the presumed role proteins in mobilization and trafficking intracellular fatty acids. Total body epididymal fat pad weights, as well adipose cell morphology, were unaltered male ALBP/aP2 disrupted when compared to their wild-type littermates. Analysis adipocytes isolated from null revealed that selective 40- 13-fold increase level keratinocyte (KLBP) mRNA...
Melanoma chondroitin sulfate proteoglycan (MCSP) is an early cell surface melanoma progression marker implicated in stimulating tumor proliferation, migration, and invasion. Focal adhesion kinase (FAK) plays a pivotal role integrating growth factor adhesion-related signaling pathways, facilitating spreading migration. Extracellular signal–regulated (ERK) 1 2, survival, has also been linked to clinical progression. We have cloned the MCSP core protein expressed it MCSP-negative line WM1552C....
Hyaluronan (HA) and its biosynthetic enzymes, HA synthases (HAS1, 2, 3) are thought to participate in cancer progression. We have shown previously that production HAS3 expression increased metastatic colon carcinoma cells (SW620) when compared with isolated from a primary tumor (SW480). Because invasion of the extracellular matrix is fundamental event growth metastasis, we hypothesized SW620 would show greater invasive capability than SW480 cells, dependent, mediates via interaction...
Abstract The intracellular effects and overall efficacies of anticancer therapies can vary significantly by tumor type. To identify patterns drug-induced gene modulation that occur in different cancer cell types, we measured gene-expression changes across the NCI-60 line panel after exposure to 15 agents. results were integrated into a combined database set interactive analysis tools, designated NCI Transcriptional Pharmacodynamics Workbench (NCI TPW), allows exploration molecular pathway,...
Prostate cancer metastasis to bone marrow involves initial adhesion of tumor cells the endothelium, followed by transmigration and proliferation within marrow. Rapid, specific highly metastatic prostate adenocarcinoma (PC3M-LN4) endothelial cell (BMEC) lines requires a pericellular hyaluronan (HA) matrix correlates with dramatically up-regulated HA synthase (HAS) expression. Non-metastatic (LNCaP) do not assemble matrix, adhere poorly BMECs, express normal levels HAS. Preferential carcinoma...
Bone marrow is the primary site of metastasis in patients with advanced stage prostate cancer. Prostate carcinoma cells metastasizing to bone must initially adhere endothelial sinusoids. In this report, we have modeled that interactionin vitro using two cell (BMEC) lines and four adenocarcinoma investigate adhesion mechanism. Highly metastatic PC3 PC3M-LN4 were found rapidly specifically (70–90%) BMEC-1 trHBMEC cells, but not human umbilical vein (15–25%). Specific was dependent upon...
DNA methyltransferase 3B (Dnmt3b) belongs to a family of enzymes responsible for methylation cytosine residues in mammals. contributes the epigenetic control gene transcription and is deregulated virtually all human tumors. To better understand generation cancer-specific patterns, we genetically inactivated Dnmt3b mouse model MYC-induced lymphomagenesis. Ablation function using conditional knockout T cells accelerated lymphomagenesis by increasing cellular proliferation, which suggests that...
DNA cytosine methylation is an epigenetic modification involved in the transcriptional repression of genes controlling a variety physiological processes, including hematopoiesis. methyltransferase 1 (Dnmt1) key enzyme somatic inheritance and thus plays critical role epigenomic stability. Aberrant contributes to pathogenesis human cancer hematologic malignancies particular. To gain deeper insight into function Dnmt1 lymphoid malignancies, we genetically inactivated mouse model MYC-induced...