A5029226155- Palliative Care and End-of-Life Issues
- Neuroscience and Neuropharmacology Research
- Childhood Cancer Survivors' Quality of Life
- Family and Patient Care in Intensive Care Units
- Carbohydrate Chemistry and Synthesis
- Electronic Health Records Systems
- Lysosomal Storage Disorders Research
- Glycosylation and Glycoproteins Research
- Ion channel regulation and function
- Alzheimer's disease research and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Drug Transport and Resistance Mechanisms
- Patient Dignity and Privacy
- Healthcare Systems and Technology
- Chronic Disease Management Strategies
- Trauma and Emergency Care Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Arrest and Resuscitation
- Frailty in Older Adults
- Neural dynamics and brain function
- Epilepsy research and treatment
- Grief, Bereavement, and Mental Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Coding and Health Information
- Health Literacy and Information Accessibility
University of Alabama at Birmingham
2011-2024
RELX Group (United States)
2023
Institute of Neurobiology
2015-2017
University of Edinburgh
2012-2015
Glasgow Centre for Population Health
2014
University of Vermont
2000
Medical Center Hospital
1999
Epilepsy is one of the most common chronic neurologic diseases, yet approximately one-third affected patients do not respond to anticonvulsive drugs that target neurons or neuronal circuits. Reactive astrocytes are commonly found in putative epileptic foci and have been hypothesized be disease contributors because they lose essential homeostatic capabilities. However, since brain pathology induces become reactive, it difficult distinguish whether astrogliosis a cause consequence...
SLC7A11, the catalytic subunit of cystine/glutamate antiporter, System x c − (SXC), is up-regulated in a subpopulation patient gliomas, where it responsible for excitotoxic glutamate release, accelerated tumor growth, and tumor-associated seizures.
Neuronal hyperexcitability occurs early in the pathogenesis of Alzheimer's disease (AD) and contributes to network dysfunction AD patients. In other disorders with neuronal hyperexcitability, dendrites often contributes, but dendritic excitability has not been directly examined models. We used patch-clamp recordings measure CA1 region hippocampus. found that dendrites, more so than somata, hippocampal neurons were hyperexcitable mice overexpressing Aβ. This was associated depletion Kv4.2, a...
Seizures frequently accompany gliomas and often escalate to peritumoral epilepsy. Previous work revealed the importance of tumor-derived excitatory glutamate (Glu) release mediated by cystine-glutamate transporter (SXC) in epileptogenesis. We now show a novel contribution GABAergic disinhibition disease pathophysiology. In validated mouse glioma model, we found that parvalbumin-positive inhibitory interneurons are significantly reduced, corresponding with deficits spontaneous evoked...
Summary Purpose: Patients with gliomas frequently present seizures, but the factors associated seizure development are still poorly understood. In this study, we assessed peritumoral synaptic network activity in a glioma animal model and tested contribution of aberrant glutamate release from on glioma‐associated epileptic activity. Methods: vitro brain slices were made glioma‐implanted mice. Using extracellular field recordings, analyzed epileptiform induced by Mg 2+ ‐free medium...
Objective Computerized decision support systems (CDSS) are commonly deployed to prescribing, although over-riding of alerts by prescribers remains a concern. We aimed understand how general practitioners (GPs) interact with prescribing CDSS in order inform deliberation on better decisions primary care. Materials and methods Quantitative qualitative analysis interactions between GPs, patients, computer using multi-channel video recordings 112 care consultations eight GPs three UK practices....
CD2-associated protein (CD2AP) is a leading genetic risk factor for Alzheimer's disease, but little known about the function of CD2AP in brain. We studied CD2AP–/– mice to address this question. Because normally die by 6 weeks from nephrotic syndrome, we used that also express transgene kidney, not brain, attenuate phenotype. CD2AP-deficient had no behavioral abnormalities except mild motor and anxiety deficits subset exhibiting severe associated with systemic illness. Pentylenetetrazol...
Temporal lobe epilepsy (TLE) patients exhibit signs of memory impairments even when seizures are pharmacologically controlled. Surprisingly, the underlying molecular mechanisms involved in TLE-associated remain elusive. Memory consolidation requires epigenetic transcriptional regulation genes hippocampus; therefore, we aimed to determine how DNA methylation affect learning-induced transcription memory-permissive epileptic hippocampus.Using kainate rodent model TLE and focusing on...
Extending palliative care to those with advanced non-malignant disease is advocated, but the implications in specific conditions are poorly understood.We piloted a novel nurse-led intervention, HELPing older people very severe chronic obstructive pulmonary (HELP-COPD), undertaken 4 weeks after discharge from hospital, which sought identify and address holistic needs of COPD.This 6-month mixed-method feasibility pilot trial randomised (ratio 3:1) patients HELP-COPD or usual care. We assessed...
O-GlcNAcylation is a ubiquitous and dynamic post-translational modification involving the O-linkage of β-<i>N</i>-acetylglucosamine to serine/threonine residues membrane, cytosolic, nuclear proteins. This similar phosphorylation regarded as key regulator cell survival homeostasis. Previous studies have shown that serine on synaptic proteins major strength long-term plasticity, suggesting likely important phosphorylation; however, few investigated its role in efficacy. We recently...
Despite apparent unmet needs, people with chronic obstructive pulmonary disease (COPD) rarely ask for help. We explored the concept of need from perspective patients, their family carers and professionals.We recruited inpatients at two National Health Service (NHS) Lothian hospitals to a structured, holistic review care needs delivered home by respiratory nurse 4 weeks postdischarge. Using semistructured interviews group discussions, notes field-notes we views professionals on perceptions...
Background: Since 2012, all GP practices across Scotland have been supported to take a systematic approach end-of-life care, by helping them identify more patients for palliative care through Palliative Care Directed Enhanced Service (DES).We aimed understand the impact of this initiative.Methods: Routine quantitative data from 2012/13, and 2013/14 DES were collected regional health boards, analysed discussed.Qualitative sample 2012/13 returns using Thematic Analysis.Results: Data received...
Background Recently acquired data suggest that prehospital fluid resuscitation may worsen outcome of patients with penetrating torso trauma. In head injury, delayed (DR) could lead to secondary cerebral ischemia. We hypothesized standard (SPR) lactated Ringer's solution or diaspirin cross-linked hemoglobin would reduce ischemia compared DR. Methods Anesthetized swine were randomized receive SPR, hemoglobin, DR after cryogenic brain injury and uncontrolled hemorrhagic shock studied for 70...
Summary Studies have demonstrated that the membrane attack complex ( MAC ) of complement can evoke seizures when injected directly into rodent brain. In course studies examine role in development experimental cerebral malaria ECM ), we observed fewer mice deficient C5, a component required for formation. To determine if contributed to tonic–clonic characteristic , performed long‐term video–electroencephalography EEG on C5 −/− with Plasmodium berghei ANKA ‐induced and significantly reduced...
Background Hypotension doubles the adverse outcome of severe brain injury (BI). This finding is thought to be due secondary ischemia caused by cerebral hypoperfusion. Aggressive prehospital fluid resuscitation in BI advocated maintain mean arterial pressure (MAP). Increasing MAP before control hemorrhage increase blood loss and reduce survival. We hypothesized that vasoconstrictor treatment uncontrolled would MAP, volume, decrease extent compared with delayed (DR) or Ringer’s lactate (RL)....
Abstract Background Sharing the electronic health‐care record ( EHR ) during consultations has potential to facilitate patient involvement in their health care, but research about this practice is limited. Methods We used multichannel video recordings identify examples and examine of screen‐sharing within 114 primary care consultations. A subset 16 was viewed by general practitioner and/or 26 reflexive interviews. Screen‐sharing emerged as a significant theme explored further seven...
Systematic reviews have suggested that time spent on computer-related tasks increases consultation length. However, these pre-date the current ubiquitous use of computers in U.K. general practice.As part a national study influence information technology (IT) interaction between patients and healthcare professionals during consultations, we explored how IT functions affected allocation styles computer practitioner (GP) consultations.We drew multichannel video recording consultations measured...
Abstract Background Sars-CoV-2, the causative agent of COVID-19, has led to more than 226,000 deaths in UK and multiple risk factors for mortality including age, sex deprivation have been identified. This study aimed identify which individual indicators Scottish Index Multiple Deprivation (SIMD), an area-based index, were predictive mortality. Methods was a prospective cohort anonymised electronic health records 710 consecutive patients hospitalised with Covid-19 disease between March June...